Yolk globulin effervescent tablet and preparation method thereof

A technology of egg yolk globulin and egg yolk globulin powder, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Immunity, anti-infection effect

Inactive Publication Date: 2021-03-30
江苏协合转化医学研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Egg yolk globulin powder is a protein prepared by high-tech processes such as fresh egg yolk diluted with water, concentrated by ultrafiltration, sterilized by microfiltration, and freeze-dried. However, there are no related reports on the application of yolk globulin powder on effervescent tablets

Method used

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  • Yolk globulin effervescent tablet and preparation method thereof
  • Yolk globulin effervescent tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0117] Each component of each egg yolk globulin effluent (unit is mg) is:

[0118] Yamaniol P100T: 40mg;

[0119] Water-free citric acid: 1400 mg;

[0120] Lactose: 280 mg;

[0121] Sunset yellow: 0.4mg;

[0122] Lactose 11SD: 400 mg;

[0123] Yamaniol P20 / 60: 369.2 mg;

[0124] Sodium bicarbonate: 920 mg;

[0125] Subbin Powder (HP): 200.4 mg;

[0126] Navy powder: 40mg;

[0127] Clove powder: 40mg;

[0128] Broccoli: 40mg;

[0129] Moringa Leaf Powder: 50mg;

[0130] Sweet orange fruit powder: 40mg;

[0131] Sweet Orange Fragrance: 20mg;

[0132] Niuurine: 4mg;

[0133] Potassium chloride: 60 mg;

[0134] Asa: 32mg;

[0135] Anse honey: 8mg;

[0136] L-leucine: 36mg;

[0137] Polyethylene glycol 6000: 20 mg.

Embodiment 2

[0139] Such as figure 2 As shown, the manufacturing process of the egg yolk glutating tablets in the preparation of 1,000 pieces of real estate example includes the following steps:

[0140] 1) Original accessories pretreatment:

[0141] Potassium L-leucine, taurine, and potassium chloride were pulverized and spare.

[0142] 2) Granulation:

[0143] Key Equipment Name: LHSG-40 High Efficiency Wet Mixed Plate Machine and YK-160 Swing Granulation Machine;

[0144] Key Process Parameters (CPP):

[0145] 21) Coloring agent configuration: Dispersion of sunset yellow in 95% ethanol, stir mix and mix, and heat the pigment is uniform, spare;

[0146] 22) Add anhydrous citric acid, sorbitol P100T, lactose to a wet-granulator, and open the stirring speed of 150 r / min, granulation speed 500R / min, mixed for 5 minutes;

[0147] 23) Set the stirring speed of 150R / min, the granulation speed 600R / min (the granulation speed range is 500-800 r / min), and the configured colorant (time consu...

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Abstract

The invention discloses a yolk globulin effervescent tablet and a preparation method thereof. The preparation method comprises the following steps: 1) pretreating raw materials and auxiliary materials; 2) granulation: 2-1) preparation of a colorant: dispersing sunset yellow in 34g of 95% ethanol, and uniformly mixing the solution for later use; 2-2) adding anhydrous citric acid, sorbitol P100T andlactose into a wet type granulator together, setting the stirring speed to be 150 r / min and the granulating speed to be 500 r / min, and mixing the raw materials; 2-3) setting the stirring speed to be150 r / min and the granulating speed to be 500-800 r / min, and adding the prepared coloring agent at a constant speed to obtain a soft material; 3) drying: setting the drying temperature to be 55 DEG C,respectively starting a dehumidification motor and a circulating motor for heating, pushing the prepared wet particles into a drying oven for drying, and controlling the moisture content to be 0.5-1.5%; 4) shaping the granules; 5) blending all the components; and 6) tabletting the blended materials. According to the present invention, the egg yolk globulin powder (HP type), namely the serum haptoglobin (Hp), is extracted; the prepared effervescent tablet has advantages of good taste, high protein content and simple preparation process, can be used as the tablet suitable for supplementing proteins, and can be easily absorbed by human bodies.

Description

Technical field [0001] The present invention relates to a maternal protein bubble tab and a preparation method thereof. Background technique [0002] The effervescent film is a new drug dosage form in my country. Unlike ordinary tablets, the effervescent tablets are used for the use of organic acid and alkali carbonated (hydrogen) salt to make the residualized agent, placed in water, instantly generate the effusion The reaction, generates and releases a large amount of carbon dioxide gas, such as boiling, so that the fuse is a tablet suitable for supplementary nutrients. [0003] Subbenoptrin powder is a protein made from high-tech processes, ultrafiltration concentration, microfiltration and freeze drying, etc., but has not seen related reports of egg yolk powder in the effervescent sheet. . Inventive content [0004] In response to the above problems, the present invention provides an advantage of a maternal protein bubble and a preparation method thereof, and the prepared eff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/46A61K36/61A61K39/395A61K47/10A61K47/12A61K47/26A61K47/18A61K47/20A61P1/00A61P37/04A61K36/185A61K36/31
CPCA61K39/395A61K36/185A61K36/61A61K36/31A61K9/0007A61K9/2018A61K9/2031A61K9/2013A61P1/00A61P37/04A61K2300/00
Inventor 程晓紊
Owner 江苏协合转化医学研究院有限公司
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