A kind of notoginseng compound composition and its application

A composition and technology of Panax notoginseng are applied in the field of biomedicine to achieve the effect of excellent liver protection

Active Publication Date: 2022-07-22
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are few drugs for the treatment of liver injury clinically, and there is an urgent need to develop new natural sources of drugs for the treatment of liver diseases

Method used

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  • A kind of notoginseng compound composition and its application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: the preparation method of notoginseng compound composition is as follows:

[0012] Take 1000 g of Panax notoginseng powder, add 10 L of 20% ethanol aqueous solution by volume, heat under reflux at 50°C for 4 hours, filter the residue and extract with ethanol solution again, combine the filtrates, and concentrate under reduced pressure to obtain 260 g of Panax notoginseng extract;

[0013] Take 1000 g of Cornus officinalis powder, add 10 L of 95% ethanol solution by mass, heat under reflux at 50°C for 4 hours, filter and extract the residue with ethanol solution again, combine the filtrates, and concentrate under reduced pressure to obtain 170 g of Cornus officinalis extract;

[0014] Take 1000 g of Schisandra chinensis powder, add 10 L of 95% ethanol solution by mass, heat under reflux at 50°C for 4 hours, filter the residue and extract with ethanol solution again, combine the filtrates, and concentrate under reduced pressure to obtain 180 g of Schisandra c...

Embodiment 2

[0016] Embodiment 2: the preparation method of notoginseng compound composition is as follows:

[0017] Take 1000 g of Panax notoginseng powder, add 20 L of 30% ethanol aqueous solution by volume, heat under reflux at 60°C for 3 hours, filter the residue and extract with ethanol solution again, combine the filtrates and concentrate under reduced pressure to obtain 280 g of Panax notoginseng extract;

[0018] Take 1000 g of Cornus officinalis powder, add 20 L of 95% ethanol solution by mass, heat under reflux for 3 hours at 60°C, filter and extract the residue with ethanol solution again, combine the filtrates, and concentrate under reduced pressure to obtain 185 g of Cornus officinalis extract;

[0019] Take 1000 g of Schisandra chinensis powder, add 20 L of 95% ethanol solution by mass, heat under reflux for 3 hours at 60°C, filter and extract the residue with ethanol solution again, combine the filtrates, and concentrate under reduced pressure to obtain 200 g of Schisandra ch...

Embodiment 3

[0021] Embodiment 3: the preparation method of notoginseng compound composition is as follows:

[0022] Take 1000 g of Panax notoginseng powder, add 30 L of 40% ethanol aqueous solution by volume, heat under reflux at 70°C for 2 hours, filter the residue and extract with ethanol solution again, combine the filtrates and concentrate under reduced pressure to obtain 270 g of Panax notoginseng extract;

[0023] Take 1000 g of Cornus officinalis powder, add 30 L of 95% ethanol solution by mass, and heat under reflux at 70°C for 2 hours. After filtering, the residue is extracted with ethanol solution again, and the filtrates are combined and concentrated under reduced pressure to obtain 178 g of Cornus officinalis extract;

[0024] Take 1000 g of Schisandra japonica powder, add 30L of 95% ethanol solution by mass, heat under reflux at 70°C for 2 hours, filter the residue and extract with ethanol solution again, combine the filtrates, and concentrate under reduced pressure to obtain ...

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Abstract

The invention discloses a Panax notoginseng compound composition. The composition and weight parts of the Panax notoginseng compound composition are 15-25 parts of Panax notoginseng extract, 8-12 parts of Cornus officinalis extract, and 8-12 parts of Schisandra chinensis extract; The compound composition of Panax notoginseng in proportion has a protective effect on the acute liver injury of mice caused by carbon tetrachloride, can effectively reduce the content of ALT and AST in the serum of mice, and the liver-protecting effect is better than that of the single extract; The preparation method is simple, the operation steps are controllable, and the content of active ingredients is high, which can be used in the preparation of medicines for treating and preventing various liver diseases.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, in particular to a compound composition of Panax notoginseng and its application. Background technique [0002] In recent years, the incidence of hepatitis, fatty liver, alcoholic liver disease, liver fibrosis, liver cirrhosis, and liver cancer in my country is on the rise, and the damage of liver function has seriously affected human health. Liver damage is mainly caused by viral infections, hepatotoxic drugs, and toxic chemicals. At present, there are few drugs used for the treatment of liver injury clinically, and there is an urgent need to develop new drugs for the treatment of liver diseases from natural sources. [0003] Sanqi Panax notoginseng (Burk.) F. H. Chen is a precious Chinese herbal medicine with a sweet and slightly bitter taste, and has various effects such as reducing swelling and pain, promoting blood circulation and removing blood stasis, hemostasis, anti-inflammatory, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/79A61K36/57A61P1/16
CPCA61K36/258A61K36/40A61K36/79A61K36/57A61P1/16A61K2236/333A61K2236/39A61K2300/00
Inventor 曲媛林雨佘亮魏馨瑶姜世丹
Owner KUNMING UNIV OF SCI & TECH
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