Refining method of high-quality sulfadoxine

A technology of sulfadoxine and refining method, which is applied in the field of medicine and can solve problems such as the color of the solution is not deep and the properties of the product are difficult to achieve.

Pending Publication Date: 2021-04-02
CHONGQING KANGLE PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

CN103910685A has described the conventional refining method of sulfadoxine, but the product character that conventional refining method obtains is difficult to reach the standard of white or milky white crystalline powder, solution color is not darker than standard solution Yw3

Method used

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  • Refining method of high-quality sulfadoxine
  • Refining method of high-quality sulfadoxine
  • Refining method of high-quality sulfadoxine

Examples

Experimental program
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Embodiment 1

[0027] The refining of embodiment 1 high-quality sulfadoxine

[0028] Add 500g of purified water, start stirring, add 50.0g of crude sulfadoxine, and raise the temperature to 55°C-65°C;

[0029] Use food-grade calcium hydroxide to adjust the pH to 10.0-10.5 and dissolve completely, and retest the pH after 15 minutes until the pH remains unchanged;

[0030] Add 5g of activated carbon, decolorize at 65℃~70℃ for 30 minutes;

[0031] Filtrate while hot, wash the carbon residue with 15g of purified water, and transfer the filtrate to a crystallization bottle;

[0032] The filtrate is added dropwise to the filtrate at a temperature of 55°C to 65°C under stirring with a purified aqueous solution of 10% analytically pure glacial acetic acid to precisely adjust the pH to 8.0, and the yellow sulfadoxine is precipitated and separated;

[0033] Add the purified aqueous solution of analytically pure glacial acetic acid dropwise to the filtrate of the previous step under stirring at a tem...

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Abstract

The invention discloses a refining method of high-quality sulfadoxine. Food-grade calcium hydroxide is adopted as a salt forming agent of sulfadoxine, a calcium salt aqueous solution of sulfadoxine issubjected to decoloration treatment, and then a purified aqueous solution of analytically pure glacial acetic acid is used for regulating the pH value in two times for fractional crystallization, sothat high-quality sulfadoxine is obtained. The sulfadoxine refined by using food-grade calcium hydroxide as a salt forming agent has low metal element residue, and the high-quality sulfadoxine obtained by two times of pH adjustment and fractional crystallization is white in appearance and light in solution color.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a refining method of sulfadoxine. Background technique [0002] Sulfadoxine is also known as Zhouxiao Sulfa, English name: Sulfadoxine, chemical name: 4-(p-aminobenzenesulfonylamino)-5,6-dimethoxydoxine, CAS registration number: 2447-57-6, chemical The structural formula is as follows: [0003] [0004] Sulfadoxine is a sulfonamide antibiotic. Sulfadoxine has the characteristics of long curative effect and low toxicity. It can treat common inflammations such as upper respiratory tract infection pancreatitis, bacillary dysentery enteritis and skin infection, etc., and it has certain curative effect on the treatment of pulmonary tuberculosis and lymphatic tuberculosis when it is compatible with other drugs. It can also treat Malaria, in addition, sulfadoxine can also be used as a preventive drug for rheumatic venereal diseases. Sulfadoxine has been included in th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D239/69
CPCC07D239/69
Inventor 蔡中文宋小莉谢晓芹
Owner CHONGQING KANGLE PHARMA
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