Flow focusing type one-step-process double-emulsion-droplet parallel generation device and method

Abstract

The invention discloses a flow focusing type one-step-process double-emulsion-droplet parallel generation device and method. The device comprises a fluid injection module, a droplet generation module, a droplet surface curing module and a droplet collection module, wherein the fluid injection module is used for conveying each phase of fluid into the droplet generation module; the liquid drop generation module comprises a fluid distribution functional area, a liquid drop preparation functional area and an auxiliary functional area; the droplet distribution functional area is used for conveying each phase of fluid into each phase of fluid channel corresponding to the droplet preparation functional area, and each phase of fluid is broken after being gathered to the same point in a flow focusing structure, so an intermediate phase fluid coats an inner phase fluid, an outer phase fluid coats the intermediate phase fluid, and double emulsion droplets are generated; the generated double emulsion droplets are cured through the droplet surface curing module; and the droplets are collected by the droplet collection module. The device disclosed by the invention can realize more stable and higher droplet yield at low cost, is simple in structure and convenient to manufacture, and can shorten the manufacturing time of a micro-fluidic chip.

Description

technical field [0001] The invention relates to a double-emulsion droplet preparation device and a preparation method, in particular to a flow-focused one-step double-emulsion droplet parallel generation device and method. Background technique [0002] In recent years, droplet microfluidic technology is an important branch of microfluidic technology, which is widely used in biology, food, chemical industry, medicine, agriculture and other fields. Double emulsion droplets are highly structured fluids in which smaller droplets are wrapped in dispersed phase droplets. The mesophase droplets form a shield around the inner phase droplets to isolate the inner droplets from the continuous phase. By curing the mesophase Droplets can make double emulsion droplets into a capsule-like structure, adjust the properties of the middle phase fluid, and make the capsule-like structure break under specific circumstances to release the inner phase fluid. The generation method of double emulsi...

AI Technical Summary

Problems solved by technology

[0003] Microfluidic technology is to manipulate the fluid in the microchannel of the chip. The minimum channel size is generally tens of microns, the flow resistance is large, it is easy to block, the operation is unreliable, and the droplet output is very low; in addition, the general double emulsion droplet The structure of the generated chip is complex and expensive, which restricts the mature application of this technology to industrialization

The description of the Chinese invention patent (authorized announcement number is CN106215990B) records a microfluidic module for large-scale preparation of droplets. The structure adopts a multi-level modular amplification strategy, and the module design includes two amplification processes of parallel connection and stacking; The fluid distribution layer of the structure adopts a narrow serpentine channel to ensure the fluid distribution effect, but the channel becomes longer and the flow resistance becomes larger, which increases the pressure of the inlet and the channel; and in the stacking process of the chipset, the serpentine distribution The settings should be calculated and checked according to the criteria for achieving uniform fluid distribution, which increases the difficulty of designing and manufacturing flow channels

Images