Model for predicting curative effect of hepatocellular carcinoma immunotherapy and construction method thereof

A technology for immunotherapy and hepatocellular carcinoma, applied in the field of clinical medicine
CN112614546AActive Publication Date: 2021-04-06ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2021-04-06

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Abstract

The invention belongs to the field of clinical medicine, and relates to a model for predicting the curative effect of hepatocellular carcinoma immunotherapy based on 5 genes and a construction method thereof. The model for predicting the immunotherapy effect of hepatocellular carcinoma comprises five genes, namely lactic dehydrogenase A (LDHA), phosphatide phosphoramidate heterogeneous enzyme (PPAT), a bead fiber structural protein 1 (BFSP1), a nuclear receptor sub-fiber 0 group B member 1 (NR0B1) and 6-phosphatide-2-kinase / fructolase-2,6-diphosphatase 4 (PFPFB4). The invention also provides a construction method of the model for predicting the curative effect of hepatocellular carcinoma immunotherapy based on the 5 genes. Herein, the new immune microenvironment model based on 5 genes is established, so that the effect of a patient on HCC immunotherapy can be effectively predicted, and the 5 genes can be used as potential biomarkers to be clinically applied.
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Description

technical field

[0001] The invention belongs to the field of clinical medicine, and relates to a 5-gene-based model for predicting the therapeutic effect of hepatocellular carcinoma immunotherapy and a construction method thereof. Background technique

[0002] Hepatocellular carcinoma (HCC) is a highly malignant cancer and the third leading cause of cancer-related death worldwide. The 5-year survival and overall survival were less than 12%. Most HCC patients develop from liver cirrhosis, chronic hepatitis virus infection, alcohol-related liver disease, nonalcoholic fatty liver disease, and drug-induced hepatitis. Since HCC is usually not diagnosed early, treatment is less effective. Therefore, the development of new diagnostic molecular markers is very important to improve the prognosis of patients.

[0003] The immune microenvironment plays a key role in tumorigenesis and is associated with tumor progression and therapeutic efficacy. Systemic immunotherapy has shown eff...

Claims

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