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Automated method for treating a biological tissue in order to produce a tissue matrix

A biological tissue and tissue matrix technology, applied in tissue regeneration, biochemical cleaning devices, biochemical equipment and methods, etc., can solve problems such as being not cheap and ecological

Pending Publication Date: 2021-04-09
THERACELL CONSULTING SPRL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This way of working is neither ecological nor cheap

Method used

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  • Automated method for treating a biological tissue in order to produce a tissue matrix
  • Automated method for treating a biological tissue in order to produce a tissue matrix
  • Automated method for treating a biological tissue in order to produce a tissue matrix

Examples

Experimental program
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Embodiment Construction

[0076] refer to figure 1 and figure 2 , shows the process and the reactor described in WO2018122039, and in the reactor 2, a series 13 of automatic devices 313, 323, 333 and 343 cooperating with each other are arranged to implement the various steps of the process. The series of automatic devices 13 is preferably controlled by a computer system 14 to which an operator may have given instructions via a control station 15 (here a computer).

[0077] The reactor 2 includes an airlock 3 for introducing and sorting biological tissues taken from the donor, and an airlock 9 as an outlet for the packaged tissue matrix, and each airlock here is placed in the reactor one end. Here, five pieces of equipment are placed side by side between two airlocks: a centrifuge 16, a cutting unit 17, a chemical treatment station 18 placed under a hood 22, a freeze-dryer 20 and a packaging station 21, respectively located in front of them Robots, here four articulated robotic arms 313 , 323 , 333 ...

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Abstract

The invention concerns an automated method for treating a biological tissue in order to produce a tissue matrix for allograft or xenograft, wherein the following sequence of steps: a) introducing said tissue into a treatment solution, b) treating the tissue in the solution, while stirring, c) removing the tissue from the treatment solution and d) emptying the reactor vessel, is repeated until the end of the treatment, and wherein all of the steps of all of the sequences are implemented automatically in a "classified" enclosure and inside a single reactor vessel, by changing the treatment solution in the reactor vessel between two sequences. The reactor vessel comprises a container designed to contain a biological tissue treatment solution into which a removable biological tissue receiver and stirring means are introduced.

Description

technical field [0001] This application relates to the field of production of human or animal tissues for use in transplantation (allograft or xenograft). Background technique [0002] Allogeneic transplantation involves a human recipient and a donor. Autologous transplantation involves a single person. [0003] Xenotransplantation involves an animal donor and a human recipient. [0004] An increasing number of human musculoskeletal disorders require bone replacement in the field of dentistry (maxillofacial reconstruction with dental implants) as well as in oncology (following bone tumor resection) or in orthopedics (following fractures or for vertebral fusion) or bone reconstruction. [0005] Currently, bone reconstruction is accomplished with autografts, usually through bone aspiration at the level of the iliac crest in those in need of treatment. However, this puncture is not only painful, but also irreversible. In fact, the hip bone does not regenerate, so the amoun...

Claims

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Application Information

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IPC IPC(8): A61L27/36B01L1/04C12M1/00C12M3/00C12M1/36
CPCA61L27/36B01L3/5021B01L9/06B01L2300/0609B01L2300/0832A61L27/3683A61L27/3691A61L27/365A61L27/3608A61L2430/02C12N5/0697
Inventor 丹尼斯·杜夫兰
Owner THERACELL CONSULTING SPRL
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