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Polypeptide microneedle and preparation method thereof

A technology of microneedles and needle bodies, which is applied in the direction of microneedles, needles, and medical formulas, and achieves the effects of simple preparation method, eye bag removal, and low cost

Pending Publication Date: 2021-04-13
宇肽生物(东莞)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although peptides have a high effect on skin remodeling, it is still difficult for some peptides to exert their due effects under the condition of transdermal administration

Method used

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  • Polypeptide microneedle and preparation method thereof
  • Polypeptide microneedle and preparation method thereof
  • Polypeptide microneedle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Preparation of anti-wrinkle and anti-aging polypeptide microneedles

[0029] 1.1 Preparation of needle solution

[0030] According to the mass percentage, 85% hyaluronic acid, 0.01% acetyl hexapeptide-8, 0.005% β-alanyl hydroxyprolyl diaminobutyryl benzylamide, and the rest of water are fully stirred and mixed Dissolved and vacuum degassed to obtain a needle solution.

[0031] 1.2 Preparation of pedestal solution

[0032] According to the mass percentage, hyaluronic acid is added into water, stirred and dissolved to obtain a solution with a mass fraction of 1.5%, and a base solution is obtained after vacuum defoaming treatment.

[0033] 1.3 Preparation of anti-wrinkle and anti-aging polypeptide microneedles

[0034] Pour the needle solution into the female mold. After the needle solution fills the pinholes of the mold, cover the base solution on the mold containing the needle solution, and dry it at a temperature of 25°C and a humidity of 30%. 10h, after d...

Embodiment 2

[0035] Example 2 Preparation of Acne Removing and Repairing Polypeptide Microneedles

[0036] 2.1 Preparation of needle solution

[0037] According to the mass percentage, 85% hyaluronic acid, 0.01% myristoyl hexapeptide-23, 0.0015% hexapeptide-9, and the rest of water are fully stirred and dissolved, and the needle body solution is obtained after vacuum defoaming treatment .

[0038] 2.2 Preparation of pedestal solution

[0039] According to the mass percentage, hyaluronic acid is added into water, stirred and dissolved to obtain a solution with a mass fraction of 1.5%, and a base solution is obtained after vacuum defoaming treatment.

[0040] 2.3 Preparation of acne repairing polypeptide microneedles

[0041] Pour the needle solution into the female mold. After the needle solution fills the pinholes of the mold, cover the base solution on the mold containing the needle solution, and dry it at a temperature of 25°C and a humidity of 30%. 10h, after demoulding, it is ready...

Embodiment 3

[0042] Example 3 Preparation of Salicylic Acid Antimicrobial Peptide Microneedles

[0043] 3.1 Preparation of needle solution

[0044] According to the mass percentage, 80% hyaluronic acid, 0.01% myristoyl hexapeptide-23, 2% salicylic acid, and the rest of water are fully stirred, mixed and dissolved, and the needle body solution is obtained after vacuum defoaming treatment.

[0045]3.2 Preparation of pedestal solution

[0046] According to the mass percentage, hyaluronic acid is added into water, stirred and dissolved to obtain a solution with a mass fraction of 1.5%, and a base solution is obtained after vacuum defoaming treatment.

[0047] 3.3 Preparation of salicylic acid antimicrobial peptide microneedles

[0048] Pour the needle solution into the female mold. After the needle solution fills the pinholes of the mold, cover the base solution on the mold containing the needle solution, and dry it at a temperature of 25°C and a humidity of 30%. 10h, after demoulding, it i...

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Abstract

The invention discloses a polypeptide microneedle and a preparation method thereof. The polypeptide microneedle comprises a base and a needle body fixed to the base, wherein the base is made of a high polymer material, and the high polymer material is selected from polyvinyl alcohol, polycarboxymethyl cellulose, chondroitin sulfate, polylactic acid-polyglycolic acid copolymer, fibroin, dextrin, hyaluronic acid or gelatin; and the needle body is prepared from the following raw materials: bioactive beautifying polypeptide, hyaluronic acid and deionized water. The microneedle is simple in preparation method, low in cost and suitable for mass production, can be widely applied to the field of cosmetic polypeptide, and has the excellent effects of removing wrinkles, resisting ageing, removing acnes, repairing the skin, whitening the skin, removing freckles, relieving the skin, resisting allergy, removing under-eye puffiness or promoting hair growth and strengthening hair.

Description

technical field [0001] The invention belongs to the technical field of cosmetic polypeptides, and in particular relates to a polypeptide microneedle and a preparation method thereof. Background technique [0002] Biologically active cosmetic peptides generally have 2 to 10 amino acid residues, a molecular weight of 100 to 2000, and are highly hydrophilic. The skin is relatively impermeable, and the stratum corneum of the skin is a multi-layered lipid bilayer formed by lipid molecules, with a dense structure and no blood vessels and lymphatic vessels, which prevents the transdermal absorption of water-soluble drugs and polymer lipophilic drugs. It is the main barrier for the transdermal absorption of functional ingredients. Therefore, the transport of some hydrophilic peptides on biomembranes is limited by their hydrophilicity and affected by the structure of biomembrane barriers. Although peptides have a high efficacy on skin remodeling, it is still difficult for some pept...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/368A61K8/64A61K8/73A61K8/02A61P17/10A61P17/14A61P37/08A61Q7/00A61Q19/00A61Q19/02A61Q19/08A61M37/00
CPCA61K8/64A61K8/735A61K8/368A61K8/0204A61Q19/00A61Q19/02A61Q19/08A61Q19/005A61Q7/00A61P37/08A61P17/10A61P17/14A61M37/0015A61K2800/91A61K2800/75A61M2037/0023A61M2037/0046A61M2037/0053A61M2037/0061
Inventor 丁文锋
Owner 宇肽生物(东莞)有限公司
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