Method for simultaneously extracting notoginsenoside, panax notoginseng flavone and panax notoginseng polysaccharide and application thereof

A technology of notoginseng flavonoids and notoginseng polysaccharides, applied in the field of simultaneous extraction of notoginseng saponins, notoginseng flavonoids and notoginseng polysaccharides, can solve the problem of not fully utilizing notoginseng medicinal materials, and achieve good antioxidant activity

Active Publication Date: 2021-04-16
SOUTHWEST FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention intends to provide a method for simultaneously extracting notoginseng saponins, notoginseng flavonoid

Method used

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  • Method for simultaneously extracting notoginsenoside, panax notoginseng flavone and panax notoginseng polysaccharide and application thereof
  • Method for simultaneously extracting notoginsenoside, panax notoginseng flavone and panax notoginseng polysaccharide and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Take 1 kg of Panax notoginseng medicinal material (the dried root of Panax notoginseng, the moisture content is controlled below 10%) and grind it through 40 meshes to obtain medicinal powder. Add an ethanol solution with a volume fraction of 80% to the medicinal powder (the percentages of all alcohol solutions in this scheme refer to volume percentages), to obtain the first extraction system, and extract by hot dipping at 70° C. for 3 hours. The dosage ratio of the 80% ethanol solution and the notoginseng medicinal material is 6L:1kg. Then filter to obtain extract I and dregs I. The extract I was evaporated and concentrated under reduced pressure, and then freeze-dried to obtain a dry powder extract of Panax notoginseng total saponins. The medicinal residue I is taken, and the culture solution and Bacillus cereus are added to the medicinal residue I to obtain a fermentation system. The addition of nutrient solution is the nutrient solution of every 1kg Panax notogins...

Embodiment 2

[0036] Take 2 kg of Panax notoginseng medicinal material (dried root, water content controlled below 10%), pulverize and pass through 40 meshes to obtain medicinal powder. Add an ethanol solution with a volume fraction of 70% to the medicinal powder to obtain the first extraction system, and extract by hot dipping at 60° C. for 3 hours. The dosage ratio of the 70% ethanol solution and the notoginseng medicinal material is 5L:1kg. Then filter to obtain extract I and dregs I. The extract I was evaporated and concentrated under reduced pressure, and then freeze-dried to obtain a dry powder extract of Panax notoginseng total saponins. Take the dregs I, and add the culture medium and Bacillus cereus (Bacillus cereus) to the dregs I 14579), to obtain a fermentation system. The addition of nutrient solution is the nutrient solution of every 1kg Panax notoginseng medical material corresponding 3L, and the inoculum amount (quality) of bacillus cereus is 8% of the quality of fermenta...

Embodiment 3

[0038] Take 5 kg of Panax notoginseng medicinal material (dried root, water content controlled below 10%), pulverize and pass through 40 meshes to obtain medicinal powder. Add an ethanol solution with a volume fraction of 90% to the medicinal powder to obtain a first extraction system, and extract by hot soaking at 80° C. for 2 hours. The dosage ratio of the 90% ethanol solution and the notoginseng medicinal material is 8L:1kg. Then filter to obtain extract I and dregs I. The extract I was evaporated and concentrated under reduced pressure, and then freeze-dried to obtain a dry powder extract of Panax notoginseng total saponins. Take the dregs I, and add culture solution and Bacillus cereus (Bacillus cereus) to the dregs I 14579), to obtain a fermentation system. The addition of nutrient solution is the nutrient solution of every 1kg Panax notoginseng medical material corresponding 3L, and the inoculum amount (quality) of Bacillus cereus is 12% of the quality of fermentati...

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Abstract

The invention relates to the technical field of preparation of plant natural products, in particular to a method for simultaneously extracting notoginsenoside, panax notoginseng flavone and panax notoginseng polysaccharide and application of the method. The method sequentially comprises the following steps: carrying out hot dipping extraction on medicinal powder by using an ethanol solution with the volume fraction of 70-90%; then, using bacillus cereus for fermentation treatment of medicine residues to obtain a final fermentation system; extracting functional components in the fermentation system by using microwave assistance to obtain an extracting solution II and medicine residues II; and finally, performing microwave-assisted extraction on the medicine residues II to obtain an extracting solution III. The extracting solution I, the extracting solution II and the extracting solution III respectively contain panax notoginseng saponins, panax notoginseng total flavonoids and panax notoginseng total polysaccharides, and the active ingredients have better antioxidant activity. The preparation method of the scheme can be applied to practical operation of preparation of an antioxidant, and raw materials with excellent properties are provided for preparation, research and development of related drugs, cosmetics and the like.

Description

technical field [0001] The invention relates to the technical field of plant natural product preparation, in particular to a method for simultaneously extracting notoginseng saponins, notoginseng flavonoids and notoginseng polysaccharides and its application. Background technique [0002] The medicinal material Panax notoginseng is the dried root of Panax notoginseng (Burk.) F.H.Chen, an Araliaceae plant. It has good hemostatic effect, promotes the division and growth of various blood cells, and can significantly increase the number of red blood cells in the pathological model of hemorrhagic anemia. Anemia has a good therapeutic effect. The total saponins of Panax notoginseng are the most important functional components in Panax notoginseng, and have been extensively studied and clinically applied. However, among the medicinal materials of Panax notoginseng, the functional components worthy of further use are far more than the total saponins of Panax notoginseng. Panax noto...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K31/715A61P39/06A61K8/9789A61K8/73A61Q19/08C08B37/00A61K125/00
Inventor 施蕊何霞红王澍邓国宾熊冰杰
Owner SOUTHWEST FORESTRY UNIVERSITY
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