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Method for separating high-content carnosic acid from rosemary

A carnosic acid, high-content technology, applied in the separation/purification of carboxylic acid compounds, bulk chemical production, organic chemistry, etc., can solve the problem of solvent volume reduction, achieve strong continuity, improve extraction efficiency, and simple method easy-to-use effects

Pending Publication Date: 2021-04-16
湖南先伟阳光生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the defects in the existing process of extracting carnosic acid from rosemary, the purpose of the present invention is to provide a method for separating high-content carnosic acid from rosemary, which greatly improves the quality of the carnosic acid by using continuous countercurrent extraction equipment Extraction efficiency to achieve continuous extraction effect; at the same time, use the principle of acid protection, similar miscibility, solvent volume reduction, and the substance is saturated and precipitated to achieve the purpose of separation and purification, and prepare high-content carnosic acid

Method used

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  • Method for separating high-content carnosic acid from rosemary
  • Method for separating high-content carnosic acid from rosemary
  • Method for separating high-content carnosic acid from rosemary

Examples

Experimental program
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Embodiment 1

[0036] A production method for isolating and purifying carnosic acid from rosemary, the steps comprising:

[0037] 1) First put 60wt% ethanol into the screw main pusher of the equipment, turn on the steam switch of the equipment to raise the temperature, and when the temperature in the equipment is measured to be 50°C, take 20kg of dried rosemary leaves and feed them from the feeding port of the equipment. The speed is 8.0r / min, the speed of the screw main propeller is 20%, the addition of 60wt% ethanol is 90L, 40g of activated carbon is divided into 4 times and added once every 10min from the feed port, and the extraction time is 50min; After the mesh sieve flows out, use a diaphragm pump to pump into a precision filter equipped with a nanofiltration membrane to filter the filtrate to 80L. Concentrate under reduced pressure at 70°C to 6L, stop the concentration, and filter after cooling to obtain 1.5kg of paste A;

[0038] 2) Paste A was dissolved in 15L petroleum ether and eth...

Embodiment 2

[0046] A production method for isolating and purifying carnosic acid from rosemary, the steps comprising:

[0047] 1) First put 70wt% ethanol into the screw main pusher of the equipment, turn on the steam switch of the equipment to raise the temperature, and when the temperature in the equipment is measured to be 50°C, take 20kg of dried rosemary leaves and feed them from the feeding port of the equipment. The speed is 8.5r / min, the speed of the screw main propeller is 23%, the addition of 70wt% ethanol is 66L, 55g activated carbon is divided into 5 times and added once every 11min from the feed port end, and the extraction time is 55min; After the mesh sieve flows out, use a diaphragm pump to filter into a precision filter equipped with a nanofiltration membrane to obtain 60L of filtrate. Concentrate under reduced pressure at 70°C to 4L, stop the concentration, and filter after cooling to obtain 1.6kg of paste A;

[0048] 2) Paste A is dissolved in a mixed solvent of 32L of p...

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Abstract

The invention discloses a method for separating high-content carnosic acid from rosemary, which comprises the following steps: 1) extracting dried rosemary leaves by using continuous countercurrent extraction equipment, adding auxiliary materials for decolorization, discharging the extracting solution from a liquid outlet, carrying out coarse filtration and fine filtration to obtain a filtrate 1, carrying out vacuum concentration on the filtrate 1 in a concentration tank, standing and cooling, and filtering to obtain paste A; 2) dissolving the paste A in an extraction tank by using an acid-added organic solvent, filtering to obtain a filtrate 2, adding vegetable oil accounting for 1 / 6-1 / 2 of the mass of the paste A into the filtrate 2, concentrating under reduced pressure until no solvent drips, and standing to obtain an insoluble substance B; and 3) carrying out degreasing treatment on the insoluble substance B to obtain a product C, namely the high-content carnosic acid.

Description

technical field [0001] The invention belongs to the technical field of separation and extraction of effective plant components, and in particular relates to a method for separating high-content carnosic acid from rosemary. Background technique [0002] Rosemary is a perennial evergreen shrub of the family Lamiaceae, which is native to Europe and the Mediterranean coast of northern Africa. Its flowers and leaves can extract natural antioxidants and rosemary essential oil. [0003] Carnosic acid (CarnosicAcid), a phenolic diterpenoid fat-soluble compound, is the main antioxidant component in rosemary. Carnosic acid has the characteristics of heat resistance, high efficiency and safety, and is widely used in the fields of medicine, daily chemical, food additive, feed and edible oil. In addition to its antioxidant effect, carnosic acid can also exert various pharmacological activities such as anti-cancer, weight loss, anti-inflammation, and antibacterial. At present, the resea...

Claims

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Application Information

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IPC IPC(8): C07C62/32C07C51/47C07C51/42C07C51/43
CPCY02P20/54
Inventor 罗伟姚慧曹文豪
Owner 湖南先伟阳光生物科技有限公司
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