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Hydrogel material for 3D printing and preparation method and application thereof, and preparation method of external stimulation dual-response sodium alginate

A sodium alginate and 3D printing technology, which is applied in additive processing, prosthesis, medical science, etc., can solve the problems of single deformation form and low printing accuracy

Pending Publication Date: 2021-04-16
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the hydrogel materials currently used for 3D printing have disadvantages such as low printing accuracy and single deformation form.

Method used

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  • Hydrogel material for 3D printing and preparation method and application thereof, and preparation method of external stimulation dual-response sodium alginate
  • Hydrogel material for 3D printing and preparation method and application thereof, and preparation method of external stimulation dual-response sodium alginate
  • Hydrogel material for 3D printing and preparation method and application thereof, and preparation method of external stimulation dual-response sodium alginate

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preparation example Construction

[0033] The invention provides a method for preparing a hydrogel material for 3D printing, comprising the following steps:

[0034] mixing the sodium alginate solution and methacrylic anhydride to undergo an acylation reaction to obtain methacrylic anhydride-modified sodium alginate monomer;

[0035] Under the condition of stirring, the methacrylic anhydride sodium alginate monomer, water, photocrosslinking agent and photoinitiator are mixed to obtain the hydrogel material for 3D printing;

[0036] The mass ratio of sodium alginate to methacrylic anhydride in the sodium alginate solution is 1:(1-20).

[0037] In the present invention, unless otherwise specified, all raw materials are commercially available products well known to those skilled in the art.

[0038] The invention mixes sodium alginate solution and methacrylic anhydride to undergo acylation reaction to obtain methacrylic anhydride sodium alginate monomer.

[0039] In the present invention, the concentration of th...

Embodiment 1

[0057] In the sodium alginate solution that 100mL concentration is 0.02g / mL, add dropwise the methacrylic anhydride of 59.52mL (0.39mol), use pH test paper to measure the pH of whole polymer solution in the process of dropping, and by dropping concentration 5mol / L NaOH solution to keep the pH value of the whole solution at about 8, and react in an ice bath for 24h. After the reaction was completed, the white reaction product was precipitated in icy ethanol, filtered with suction, the obtained white powder was sonicated in icy ethanol for 1 hour, filtered with suction, and vacuum-dried at 30°C for 48 hours to obtain sodium methacrylic anhydride alginate monomer;

[0058] After dissolving 0.2 g of methacrylic anhydride sodium alginate monomer in 3.13 mL of deionized water, add 0.02 g of dimethylaminoethyl methacrylate and 0.006 g of 2-hydroxy-2-methyl-1-phenyl- 1-Acetone, stirred overnight under the conditions of avoiding light and room temperature, to obtain a hydrogel materia...

Embodiment 2

[0061] In the sodium alginate solution that 100mL concentration is 0.02g / mL, add dropwise the methacrylic anhydride of 14.88mL (0.097mol), use pH test paper to measure the pH of whole polymer solution in the process of dropping, and by dropping concentration 5mol / L NaOH solution to keep the pH value of the whole solution at about 8, and react in an ice bath for 24h. After the reaction was completed, the white reaction product was precipitated in icy ethanol, filtered with suction, the obtained white powder was sonicated in icy ethanol for 1 hour, filtered with suction, and vacuum-dried at 30°C for 48 hours to obtain sodium methacrylic anhydride alginate monomer;

[0062] After dissolving 0.2 g of methacrylic anhydride sodium alginate monomer in 3.13 mL of deionized water, add 0.02 g of dimethylaminoethyl methacrylate and 0.006 g of 2-hydroxy-2-methyl-1-phenyl- 1-Acetone, stirred overnight under the conditions of avoiding light and room temperature, to obtain a hydrogel materi...

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Abstract

The invention relates to the technical field of hydrogel, in particular to a hydrogel material for 3D printing and a preparation method and application thereof and a preparation method of external stimulation double-response sodium alginate. The preparation method provided by the invention comprises the following steps: mixing a sodium alginate solution and methacrylic anhydride, and carrying out acylation reaction to obtain a methacrylic anhydride sodium alginate monomer; under the condition of stirring, mixing the methacrylic anhydride sodium alginate monomer, water, a photo-crosslinking agent and a photoinitiator to obtain the hydrogel material for 3D printing, wherein the mass ratio of sodium alginate to methacrylic anhydride in the sodium alginate solution is 1:(1-20). When the hydrogel material prepared by adopting the preparation method is used for 3D printing, a grid structure with a fine structure can be prepared, and the prepared hydrogel has a relatively uniform tubular structure.

Description

technical field [0001] The invention relates to the field of hydrogel technology, in particular to a hydrogel material used for 3D printing, a preparation method and application, and a preparation method of sodium alginate with dual responses to external stimuli. Background technique [0002] Since the material of the hydrogel has a high porosity, the material contains a large amount of water (the water content can reach several thousand times the mass of the gel itself), and most of the constituent segments are biocompatible materials, so the hydrogel Adhesive materials are widely used in the field of biomedicine, especially as cell scaffolds, the advantages of hydrogel materials are extremely prominent, because the high porosity of hydrogel makes it easier to transport nutrients and waste materials, and Since the material contains more water, it is conducive to the proliferation and adhesion of cells on the material. [0003] As an emerging technology, 3D printing technol...

Claims

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Application Information

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IPC IPC(8): C08J3/075B33Y70/00B33Y10/00C08F251/00C08F220/34C08B37/04A61L27/20A61L27/52C08L5/04
Inventor 王齐华曹芃锐张耀明王廷梅张新瑞
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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