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Production method of lung-heat clearing and toxin expelling soup based on fingerprint model

A fingerprint, lung-clearing and detoxification technology, which is applied to anti-toxins, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of no production standards, obstacles to fingerprint detection methods, and different production processes

Active Publication Date: 2021-04-16
广东志道医药科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, because there is no report on the relevant prior art about the establishment of fingerprints of Wulingsan and Shegan Mahuang Decoction to detect the quality, it brings more technical obstacles to the establishment of fingerprint detection methods of Qingfei Paidu Decoction
[0011] In addition, since Qingfei Paidu Decoction is a newly determined prescription, there is no uniform production standard for the time being, so each manufacturer produces according to the actual situation, resulting in different production processes, which may bring certain disadvantages to the standardized production of traditional Chinese medicine preparations influences

Method used

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  • Production method of lung-heat clearing and toxin expelling soup based on fingerprint model
  • Production method of lung-heat clearing and toxin expelling soup based on fingerprint model
  • Production method of lung-heat clearing and toxin expelling soup based on fingerprint model

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Embodiment 1, test equipment and raw material

[0093] 1. Instruments and reagents

[0094] 1.1 Instrument

[0095] Thin-layer automatic imager (CAMAG TLC VISUALIZER2, Swiss CAMAG company), thin-layer plate heating plate (CAMAG TLC PLATE HEATERⅢ, Swiss CAMAG company), electronic balance (METTLER ME2002E, Mettler-Toledo Instruments (Shanghai) Co., Ltd.) , electronic balance (METTLER MS 204TS, Mettler-Toledo Instruments (Shanghai) Co., Ltd.), ultrasonic cleaner (KQ-300DE, Kunshan Ultrasonic Instrument Co., Ltd.), medical centrifuge (Xiangyi H1850 Hunan Xiangyi Laboratory Instrument Development Co., Ltd.), constant temperature water bath (HWS-26 type), plane chromatographic spotting instrument (SPDY-1A, Nanjing Microtech Scientific Instrument Co., Ltd.), silica gel G thin-layer prefabricated plate (Qingdao Ocean Chemical Factory), Silicone G thin-layer prefabricated panel (Merck, Germany)

[0096] 1.2 Reagents and Reagents

[0097] Scutellaria baicalensis reference mat...

Embodiment 2

[0114] Embodiment 2, according to " Chinese Pharmacopoeia ", explore and screen different extraction solvents (being extraction agent)

[0115] Refer to the 2015 edition of "Chinese Pharmacopoeia", "Glycyrrhiza", "Scutellaria Qin", "Dried Ginger", "Citrus Aurantium", "Shegan", "Asarum", "Orange Peel", "Patchouli" and "Xiao Bupleurum Capsules" " and other methods under the identification item, investigating the treatment of Qingfei Paidu Decoction granules with ethyl acetate, n-butanol extraction and different treatment methods.

[0116] 1. Preparation method of the test solution

[0117] (1) Take the granule test sample (batch number: 2020033001) and add 20ml of water to dissolve it, add ethyl acetate to extract twice, 20ml each time, combine the ethyl acetate extract, evaporate to dryness in a water bath, and dissolve the residue with 1ml of methanol to obtain the test sample Solution 1.

[0118] (2) Take the above remaining water layer, add n-butanol to extract twice, 20ml...

Embodiment 3

[0126] Embodiment 3, analyze and explore different thin-layer identification developing agents

[0127] Refer to the 2015 edition of "Chinese Pharmacopoeia" "Glycyrrhiza", "Scutellaria Qin", "Dried Ginger", "Citrus Aurantium", "Bitter Almond", "Shegan", "Asarum", "Orange Peel", "Patchouli" As well as the methods under the identification items such as "Xiaochaihu Capsules", the research mode of the following existing developing agents is carried out:

[0128] (1) "Glycyrrhiza" identification developer: ethyl acetate-formic acid-glacial acetic acid-water (15:1:1:2);

[0129] (2) "Scutellaria baicalensis" identification developer: toluene-ethyl acetate-methanol-formic acid (10:3:1:2);

[0130] (3) "Dried ginger" identification developer: petroleum ether (60-90°C)-chloroform-ethyl acetate (2:1:1);

[0131] (4) "Citrus aurantium" identification developer: n-butanol-glacial acetic acid-water (4:1:5);

[0132] (5) "Shegan" identification developer: chloroform-butanone-methanol (3:...

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Abstract

The invention provides a production method of lung-heat-clearing toxin-expelling decoction established based on a fingerprint spectrum model, which comprises the following steps: exploring a fingerprint mass spectrum system with optimal chromatographic parameters by using a standard test sample in advance, testing a standard control sample of a single medicine by using the chromatographic system, exploring and determining fingerprint peaks of a small amount of specific components at one time, and determining the fingerprint peaks of the specific components at the same time. so that a simplified qualitative and quantitative fingerprint spectrum model is established, and the model is used for producing the lung-heat-clearing and toxin-expelling soup. The simplified fingerprint model can be used for preliminarily and qualitatively screening unqualified lung-clearing and toxin-expelling decoction products, quantitatively analyzing qualified products, and then comprehensively analyzing the qualified products by combining with a more comprehensive thin-layer chromatography identification method. The method has the technical effects that the quality detection process is simplified, the accurate quantitative analysis effect is reserved, and the detection efficiency is improved.

Description

technical field [0001] The invention relates to a quality control method for the preparation process of Qingfei Paidu Decoction, specifically providing identification of involved Chinese medicinal materials, control of process parameters, and quality analysis of finished products for the process and preparation of "Qingfei Paidu Decoction" by fingerprint method A quality control method, and a method involving Qingfei Paidu Decoction produced according to the quality control method. Background technique [0002] Qingfei Paidu Decoction is derived from the classic combination of traditional Chinese medicine prescriptions, including Maxing Shigan Decoction, Shegan Mahuang Decoction, Xiaochaihu Decoction, Wuling Powder, and has a mild nature and flavor. The main ingredients of this prescription are: Ephedra 9g, Zhigancao 6g, Almond 9g, Gypsum 15-30g (decocted first), Guizhi 9g, Alisma 9g, Polyporus 9g, Atractylodes 9g, Poria 15g, Bupleurum 16g, Scutellaria baicalensis 6g, ginge...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/86G01N30/90G01N30/94A61K9/16A61K36/9068A61P11/00A61P39/02A61K33/06
Inventor 方铁铮陆锡傍姚振弘赵留栓龙飞廖嘉媛杨凯
Owner 广东志道医药科技有限公司