Composition for filling capsule, method for producing capsule preparation using same, and capsule preparation
A manufacturing method and composition technology, applied in the field of capsule filling compositions, capable of solving problems such as quality deviation and inability to manufacture capsule preparations with constant weight
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Embodiment 1
[0165] As the cellulose ether powder, HPMC-1 described in Table 1 was used, koji powder as the active ingredient and HPMC-1 as the cellulose ether powder were weighed and dry-mixed so as to have the content described in Table 2, Compositions for filling capsules are produced.
[0166] Using the prepared composition for capsule filling, the composition for capsule filling was compression-molded in a polycarbonate tube by the method described in the above [compression moldability] to produce a compression-molded product.
Embodiment 2～9 and comparative example 1
[0168] Using the same method as in Example 1, using the cellulose ether powder described in Table 1, the active ingredient and the cellulose ether powder were weighed and dry-mixed so as to become the content described in Table 2, and the combination for capsule filling was manufactured. objects and compression moldings. In addition, in Comparative Example 1, no cellulose ether powder was used.
Embodiment 10 and comparative example 2
[0170] Using the same method as in Example 1, using HPMC-3 recorded in Table 1, vitamin B as the active ingredient 2 , cellulose ether powder, and lactose as an excipient were weighed and mixed so as to have the contents described in Table 3, and a composition for capsule filling and a compression molded product were produced.
[0171] In addition, in Comparative Example 2, no cellulose ether powder was used.
[0172]
[0173] [Example 10 and Comparative Example 2]
[0174]After weighing 450 mg of the capsule filling compositions of Example 10 and Comparative Example 2, the compositions were put into a 7 mm diameter mortar (IPT specification; manufactured by Kikusui Seisakusho Co., Ltd.) placed on a stainless steel container. Using a tensile compression tester ("SDT-503NB"; manufactured by Imada Manufacturing Co., Ltd.), the capsule filling composition in the mortar was subjected to a 0.19N Compression molding is performed under load to produce a compression molded product...
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Abstract
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