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Electrochemical sensor capable of synchronously recording with electrophysiology

An electrochemical and sensor technology, applied in the field of biochemistry

Active Publication Date: 2021-05-04
INST OF CHEM CHINESE ACAD OF SCI
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  • Abstract
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Problems solved by technology

However, these electrochemical methods mainly rely on the application of polarization voltage on the working electrode, and the applied polarization voltage cannot avoid the influence on neuron discharge.

Method used

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  • Electrochemical sensor capable of synchronously recording with electrophysiology
  • Electrochemical sensor capable of synchronously recording with electrophysiology
  • Electrochemical sensor capable of synchronously recording with electrophysiology

Examples

Experimental program
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Effect test

Embodiment

[0083] Embodiment: Potassium ferricyanide (K 3 Fe(CN) 6 )-Ascorbic acid (AA)-based self-generating biosensor

[0084] Preparation of carbon fiber electrodes:

[0085] Firstly, a carbon fiber electrode about 10 cm long is threaded into a glass capillary (outer diameter: 1.5 mm; inner diameter: 0.89 mm; length: 10 cm) in an ethanol solution, and the threaded carbon fiber is dried in an oven at 60°C for two hours. Then two tapered capillaries with very thin tips were drawn on a horizontal laser drawer (P-2000, Sutter Instrument Co.). Under the microscope, use iris scissors to cut the exposed carbon fibers to 100-300μm, and then reversely pour the silica gel into the tip of the glass tube. Centrifuge at 7000rpm for 70 seconds. Then place the electrode at room temperature for 24 hours, and it can be used after the silica gel is cured. The prepared carbon fiber electrode (CFE) was successively dissolved in acetone, 3.0mol / L HNO 3 and 1.0mol / L KOH solution for 2min. When activ...

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Abstract

The invention relates to an electrochemical sensor capable of synchronously recording with electrophysiology, and particularly provides a carbon fiber electrode and a carbon fiber, wherein the carbon fiber electrode comprises a non-conductive capillary tube, one end of the non-conductive capillary tube is open, and the other end is sealed; the carbon fiber is arranged in the non-conductive capillary tube and extends to the outer part of the sealing port of the non-conductive capillary tube; a cathode is the carbon fiber arranged in the non-conductive capillary tube, and an anode is the carbon fiber extending to the outside of the sealing port of the non-conductive capillary tube. The inventor discovers that the carbon fiber electrode has excellent performances such as high strength, high modulus, good conductivity and large specific surface area, and is very suitable for in-vivo implantation, and the biosensor prepared by using the carbon fiber electrode can effectively avoid damage to neurons and interference to neuronal electric signals caused by external polarization voltage, synchronous recording of electrophysiology and electrochemical signals is achieved, and the electrochemical sensor has potential application prospects in the field of living body analysis and research.

Description

technical field [0001] The invention relates to the field of biochemistry, in particular, the invention relates to an electrochemical sensor which records synchronously with electrophysiology. Background technique [0002] The function of the central nervous system mainly depends on the information transmission between neurons. The way of information transmission between neurons basically follows the mode of "electrical signal-chemical signal-electrical signal" transmission. Therefore, in situ detection of the dynamic changes of neurochemical substances in the brain and the activity of neuronal electrical signals is of great significance for us to understand and understand brain activity and function. The electrical activity signals of neurons are mainly recorded by electrophysiological methods; electrochemical sensors are widely used in the detection of neurotransmitters or neuromodulators due to their advantages of high temporal and spatial resolution and high sensitivity...

Claims

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Application Information

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IPC IPC(8): G01N27/327
CPCG01N27/3277G01N27/3278
Inventor 毛兰群魏欢于萍吴菲
Owner INST OF CHEM CHINESE ACAD OF SCI
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