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Novel cutibacterium avidum strain, and composition for preventing or treating atopic dermatitis, comprising strain or cultured product thereof

A technology of Propionibacterium and Propionibacterium acnes, applied in the field of new strains and their cultures, can solve problems such as unclear etiology of AD, achieve the effect of eliminating unique odor, improving acne, and improving skin symptoms

Pending Publication Date: 2021-05-07
GENOME & CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although much research has been done on AD recently, the etiology of AD was unknown until now

Method used

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  • Novel cutibacterium avidum strain, and composition for preventing or treating atopic dermatitis, comprising strain or cultured product thereof
  • Novel cutibacterium avidum strain, and composition for preventing or treating atopic dermatitis, comprising strain or cultured product thereof
  • Novel cutibacterium avidum strain, and composition for preventing or treating atopic dermatitis, comprising strain or cultured product thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] [Example 1] Isolation and Identification of Propionibacterium valiva GENSC01

[0078] 1-1. Isolation of bacterial strains

[0079] Bacterial isolation from the skin was performed on adults who had never had a skin disorder such as atopic disease, psoriasis, or acne, or had no history of treatment associated with these disorders within the past 6 months. To collect skin samples, the unwashed cheeks and alars of the nose were swabbed vigorously with a cotton swab moistened with sterile water. The swabs were sealed directly in tubes containing enhanced Clostridium medium (RCM), and the tubes were filled with nitrogen and incubated at 37°C for 48 to 72 hours. The culture medium of the test tube containing the culture swab was collected with a platinum ring and streaked on the RCM agar plate, and this operation was repeated 3 to 4 times to isolate pure colonies.

[0080] 1-2. Identification of bacterial strains

[0081] 1) Biochemical identification using API kit

[0082...

Embodiment 2

[0088] [Example 2] Hemolysis test of Propionibacterium ravenouse GENSC01

[0089] Quite a few strains of Propionibacterium vulgaris have hemolytic toxicity and different strains are harmful to human body in different degrees. In order to confirm the safety of Propionibacterium vulgaris GENSC01, the presence or absence of hemolytic toxicity was confirmed. Propionibacterium greedy GENSC01 purely cultured in the liquid medium was collected using a platinum ring, streaked on a blood agar plate (sheep blood agar), and cultured anaerobically at 37° C. for 48 hours. Haemolyticity was determined based on the presence or absence of a transparent ring around the cells, and if figure 2 As shown in , it was determined that Propionibacterium vulgaris GENSC01 is not hemolytic to sheep blood and therefore harmless to humans.

Embodiment 3

[0090] [Example 3] Preparation of the fermentation filtrate of the bacterial strain of the present invention

[0091] The P. valiris GENSC01 strain was cultured anaerobically at 37°C for 72 hours on RCM agar plates. A single colony appearing in the solid medium was subcultured in 10 ml of RCM liquid medium and cultured under the same conditions. After 72 hours, 0.1% was inoculated to the same liquid medium, and cultured under the same conditions for 72 hours, and the supernatant was centrifuged and filtered with a 0.22um pore size filter.

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PUM

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Abstract

The present invention relates to a Cutibacterium avidum GENSC01 strain (KCTC 13596BP). The present invention also relates to a composition comprising the strain or a cultured product thereof, and a use thereof. The present invention is effective in alleviating, preventing or treating skin inflammation caused by atopic dermatitis, acne or fine dust.

Description

technical field [0001] This application claims priority based on Korean Patent Application No. 10-2018-0098879 filed on August 23, 2018, and the entire contents disclosed in the specification and drawings of this application are incorporated herein by reference. The present invention relates to novel strains and cultures thereof which are newly isolated, identified and evaluated for efficacy. In addition, the present invention relates to compositions comprising the new strain or a culture thereof. More specifically, the present invention relates to a cosmetic composition comprising novel strains or cultures thereof having various effects such as skin improving effects. Background technique [0002] When physical stimulation or chemicals, bacteria, and the like cause skin damage, an inflammatory response in the skin starts as a defense against the skin damage, and various immune cells and inflammatory cytokines are involved. IL-6 (interleukin-6), IL-8 (interleukin-8), IL-1β...

Claims

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Application Information

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IPC IPC(8): C12N1/20A61K8/37A61K8/99A61K31/216A61K35/74A61P17/00A61P17/10A61P31/04A61Q19/00C12R1/01
CPCA61P17/00A61P17/10C12N1/205C12R2001/01A61K31/216A61K35/74A61Q19/00A61K8/99A61Q17/00A61K8/375A61K2300/00A61Q19/007C12N1/20
Inventor 朴汉洙
Owner GENOME & CO
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