Preparation method and system of mixed gas for preparing intermittent hypoxia animal model

An animal model and preparation system technology, applied in the field of medical experiments, can solve the problems of incapability of animal modeling, high modeling cost, and low success rate, and achieve the effects of high modeling efficiency, improved modeling efficiency, and high success rate.

Pending Publication Date: 2021-05-14
WEST CHINA HOSPITAL SICHUAN UNIV +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides a mixed gas preparation method and system for intermittent hypoxic animal model preparation, which is used to solve the problems in the prior art that it takes a long time to mix the gas and switch the mixed gas, and the existing The animal model preparation device can only make a small number of models, and cannot carry out batch animal models at the same time. The problem of high cost of model making and low success rate

Method used

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  • Preparation method and system of mixed gas for preparing intermittent hypoxia animal model
  • Preparation method and system of mixed gas for preparing intermittent hypoxia animal model
  • Preparation method and system of mixed gas for preparing intermittent hypoxia animal model

Examples

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Effect test

Embodiment 1

[0042]Such asfigure 1 withFigure 9 As shown, a intermittent hypoxic animal model preparation system includes a gas mixing apparatus 10 that produces a low oxygen gas and a cage box 11 for placing an experimental animal via a gas mixing device 10.

[0043]The present invention can shorten the gas mixed time by inputting the gas in the gas mixing device 10 to the cage box 11, and can shorten the time of the gas mixing, and it is originally mixed in the sealing chamber of the feeding experimental animal. When the gas oxygen concentration is adjusted, since the gas mixing is performed directly in the sealing case, the present invention will affect the survival of the experimental animals, and the present invention has previously modulated oxygen concentrations of the mixed gas, and the adjustment of mixed gas inputs the experimental animal. In the cage box 11, it is more advantageous to carry out animal modeling, high moderate efficiency, high success rate.

[0044]Preferably, the exhaust gas...

Embodiment 2

[0052]In this example, the present invention is further optimized for the present invention.

[0053]Such asFigure 2-6 As shown, the mixed intake pipe 12 includes an intake main pipe 121, and there is a plurality of intake branch 122 on the intake main pipe 121, and there is a plurality of intake pipe 123, and the air supply pipe 123 is vertical. The horizontal plane of the intake main pipe 121 and the intake branch 122;

[0054]The exhaust gas air tube 13 includes a venting main pipe 131, and a plurality of air branch 132 are connected to the air, each of which is provided with a plurality of air nozzles 133, and the air nozzle 133 is perpendicular to the perpetrator 131 and the air branch 132. level;

[0055]Among them, the number and pitch of the air supply nozzle 123 on each intake branch 122 equal to the number and spacing of the outlet nozzle 133 on each air branch 132, and the number of cage boxes 11 is plural, and each cage box 11 is All of the air intake and outlet, the intake branc...

Embodiment 3

[0061]In this example, the present invention is further optimized for the present invention.

[0062]Such asFigure 3 - Figure 8As shown, the intake port and the air port are connected to the cage 15, and the cage 15 is opened from one end of the cage box 11, and the pass groove 16 is provided with a spring passage closure 17, the spring is closed. The upper end of the 17 is connected to the cage 15.

[0063]When the present invention, the intake nozzle 123 and the air supply nozzle 133 pass through the pass groove 16 corresponding to the cage 15, and the spring passage closure 17 is pushed forward, and the cage box 11 is supplied and ventilated, and the cage box is required. 11 When the seal is sealed, return the inlet nozzle 123 and the air nozzle 133, and the spring passage closing piece 17 is reset, that is, the seal of the cage box 11 can be completed.

[0064]It should be noted that the intake nozzle 123 and the air supply can be used to complete the operation of the inlet 123 and the a...

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Abstract

The invention provides a preparation method and system of mixed gas for preparing an intermittent hypoxia animal model, mainly relates to the technical field of medical experiments. The system comprises a plurality of gas mixing devices for generating hypoxia gas, a cage box which is used for placing experimental animals and which is supplied with gas through the gas mixing devices, and a waste gas treatment device, wherein the waste gas treatment device is communicated with the cage box through a waste gas outlet pipe; the gas mixing devices are communicated with the cage box through a mixed gas inlet pipe, and the multiple gas mixing devices are connected to the mixed gas inlet pipe in parallel. Gas is mixed in the gas mixing devices in advance, then the mixed gas is input into the cage box for animal modeling, the gas mixing time can be shortened, animal modeling is more facilitated, the modeling efficiency is high, the success rate is high, meanwhile, batch animal modeling can be conducted, and the animal modeling efficiency is improved. The modeling time is shortened, the cost is reduced, the application range is wide, two airflow layouts are used for experimental animals with different body types and sizes, and the practicability is high.

Description

Technical field[0001]The present invention relates to the field of medical experiment, and in particular, a method and system for preparing a batch hybrid body model is prepared by a batch hypoxic animal model.Background technique[0002]Nowadays, people pay more attention to the study of sleep-related diseases, obstructive sleep apnea low ventilation syndrome is an important sleep respiratory disease, refers to various reasons, causing respiratory suspension and / or low ventilation, high Blood condition, sleep interruption, thereby enabling the clinical syndrome of a series of pathophysiological changes in the body, chronic intermittent hypoxia in sleep is an important reason for a series of pathophysiological changes, in order to explore intermittent hypoxia, and their series The mechanism of pathological changes requires the preparation of intermittent hypoxic animal models with experimental animals. For example, a intermittent hypoxic system disclosed in the prior art CN104173119...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D7/00
CPCA61D7/00
Inventor 冉兴无钟浩冯绍明陈利鸿郭政宏
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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