Preparation method and application of copper-based-organic metal framework electrochemical sensor for determining zearalenone

A technology of zearalenone and organometallics, applied in the field of analysis and detection, can solve the problems of few reports on electrochemical sensors, expensive antibodies, and non-reproducibility, etc., and achieve short detection and analysis time, obvious selectivity, and good repeatability Effect

Active Publication Date: 2021-05-14
JIANGXI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, a large number of studies on the determination of zearalenone mainly focus on electrochemical biosensing detection technology, and there are few reports on the use of electrochemical sensors.
However, antibodies in bioassays are not only expensive, but also irreproducible and unstable

Method used

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  • Preparation method and application of copper-based-organic metal framework electrochemical sensor for determining zearalenone
  • Preparation method and application of copper-based-organic metal framework electrochemical sensor for determining zearalenone
  • Preparation method and application of copper-based-organic metal framework electrochemical sensor for determining zearalenone

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Embodiment 1

[0037] A method for preparing a copper-based-organometallic framework electrochemical sensor for measuring zearalenone, comprising the following steps:

[0038] The sodium salt of isobenzoic acid composed of 3mmol NaOH and 2mmol 1,3,5-benzoic acid was dissolved in 100mL ethanol, and 2.55mmol Cu(NO 3 ) 2 ·3H 2 O was dissolved in 100mL of deionized water, and then the mixture of the upper layer of divalent copper solution and the lower layer of sodium benzoate was carried out in a long glass test tube with 1:1 (w / w) water and ethanol solution for 30r / min with magnetic stirring for 20 minutes. After standing for four days, blue-shaped crystals were obtained from the junction between the layers and washed with ethanol solution several times, and then vacuum-dried at 100 °C to obtain copper-metal-organic framework (Cu-MOF) powder.

[0039] Firstly, the unmodified glassy carbon electrode (GCE) was polished to a mirror-like surface with 0.05 μm alumina on the washable suede, and t...

Embodiment 2

[0049] An application of a copper-based-organometallic framework electrochemical sensor for measuring zearalenone in the detection of zearalenone, comprising the following steps:

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Abstract

The invention provides a preparation method and application of a copper-based-organic metal framework electrochemical sensor for determining zearalenone, which belongs to the technical field of analysis and detection. The preparation method and application of a copper-based-organic metal framework electrochemical sensor for determining zearalenone comprise the following steps of preparing a copper-based-organic metal framework material, preparing various chemically modified electrodes, testing the surface appearance of the modified material, researching the electrochemical performance, drawing a linear relation curve, analyzing an actual sample by a standard addition method and the like. The sensor formed with a composite modified electrode Cu-MOF / Fe3O4-GO / GCE prepared by the preparation method disclosed by the invention as a working electrode becomes a good electrochemical platform for quantitatively determining the zearalenone toxin. The effective area of the composite modified electrode is 3.9 times that of an unmodified glassy carbon electrode, so that the electro-catalysis capability on the zearalenone toxin is obviously enhanced, and the composite modified electrode also has obvious anti-interference capability and good repeatability and reproducibility.

Description

technical field [0001] The invention belongs to the technical field of analysis and detection, and in particular relates to a preparation method and application of a copper-based-organometallic framework electrochemical sensor for measuring zearalenone. Background technique [0002] Zearalenone (ZEA), a fungal secondary metabolite mainly produced by Fusarium species, can cause great harm to animals and humans due to its estrogen-like effects. Among livestock, pigs, especially sows, are the most sensitive to zearalenone. Zearalenone can cause excess estrogen production, which can eventually lead to diarrhea, breast enlargement, miscarriage, and other clinical symptoms. Humans may directly or indirectly ingest zearalenone contaminated in food and agricultural by-products through the food chain. After long-term consumption of products containing zearalenone or its metabolites, the accumulated toxins and its metabolites have greater estrogen-like effects, including fertility d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/26G01N27/327G01N27/48
CPCG01N27/26G01N27/308G01N27/327G01N27/48
Inventor 汤凯洁曾一芳文阳平周雯雯
Owner JIANGXI AGRICULTURAL UNIVERSITY
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