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Myricetin/azole medicine combined liniment for preventing infection of outer surface of percutaneous catheterization catheter and application of liniment

A technology of outer surface and film coating agent, applied in the field of pharmacy, to achieve the effect of strong toughness, good water resistance and infection prevention

Active Publication Date: 2021-05-25
XI AN JIAOTONG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is currently no antimicrobial application of azole drugs combined with myricetin as a coating agent for catheter-associated infection

Method used

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  • Myricetin/azole medicine combined liniment for preventing infection of outer surface of percutaneous catheterization catheter and application of liniment
  • Myricetin/azole medicine combined liniment for preventing infection of outer surface of percutaneous catheterization catheter and application of liniment
  • Myricetin/azole medicine combined liniment for preventing infection of outer surface of percutaneous catheterization catheter and application of liniment

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Embodiment Construction

[0039]In order to better understand the present invention, the technical solutions in the embodiments of the present invention will be described in connection with the drawings in the embodiments of the present invention, and the embodiments described herein will be clearly understood. It is an embodiment of the invention, not all of the embodiments. Based on the embodiments in the present invention, those of ordinary skill in the art will belong to the scope of the invention in the present invention without making in the pre-creative labor premise.

[0040]It should be noted that the specification and claims of the present invention and the terms "first", "second", "second" or the like are used to distinguish a similar object without having to describe a particular order or ahead order. It should be understood that the data such as use can be interchanged in place so that the embodiments of the invention described herein can be implemented in the order other than those illustrated or ...

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Abstract

The invention discloses a myricetin / azole medicine combined liniment for preventing infection of the outer surface of a percutaneous catheterization catheter and application of the liniment, and belongs to the technical field of pharmaceutics. The myricetin has the activity of inhibiting the formation of a fungal Candida albicans biofilm, the myricetin is combined with the azole compound to help the azole compound break through a fungal biofilm barrier, and the synergistic effect of the myricetin and the azole compound can significantly enhance the antibacterial effect. The film coating agent can be quickly dried to form a transparent film after being applied to the skin surface, is not limited by the shape and position of a medication part, plays a physical protection role, loads myricetin and miconazole nitrate, can simultaneously avoid invasion and infection of pathogens in the external environment and the skin, is convenient to use, and the compound is expected to be used for preventing clinical catheter-related infection.

Description

Technical field[0001]The present invention belongs to the field of pharmacy, involving a coating agent for combined with a combined with Yangmei / azole drug infected with an outer surface of the leather pipe catheter.Background technique[0002]With biomedical materials (orthopedic implants, medical catheters, cardiac pacemakers, etc.) are widely used in clinical, and infections involved have become tricky clinical problems, this is due to biological material implantation, in addition to increased pathogens The approach of invading the body also reduces the number of minimum pathogens required for induced body infection, and both greatly increase the risk of body infection. Catheter-related infections are one of the most common acquired infections in hospitals, diagnosed, and many hazardous factors. Among them, four major pathogens infected with leather tube conduit were: Sapoccus, Golden Staphylococcus, Candida, Golden Staphylobacterium, Golden Color Staphylobacterium. When the path...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K45/06A61K31/352A61K31/4174A61K31/4196A61K31/496A61K31/506A61K47/32A61P17/00A61P31/10
CPCA61K45/06A61K31/352A61K31/4174A61K31/496A61K31/4196A61K31/506A61K9/7015A61K47/32A61P31/10A61P17/00A61K2300/00Y02A50/30
Inventor 张继业莫菲张沛沛李清清杨显伟马佳苏进
Owner XI AN JIAOTONG UNIV
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