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Preparation method of mitomycin C ophthalmic preparation

A technology for mitomycin and ophthalmic preparations, applied in the field of preparation of mitomycin C ophthalmic preparations, can solve the problems of low solubility and poor stability, and achieve the effects of high solubility, good stability and improved stability

Inactive Publication Date: 2021-06-01
JIANGSU JINGLIXIN PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Aiming at the problems of low solubility and poor stability of existing mitomycin C, the present invention provides a preparation method of inclusion compound of mitomycin C ophthalmic preparation

Method used

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  • Preparation method of mitomycin C ophthalmic preparation

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]The hydroxypropyl-β-cyclodextrin is dissolved in 100 ml of water, continuously stirring until the solution is clarified, adding 0.9 g of sodium sodium chloride, adding mitomycin C 0.1 g, continuously stirring until the solution is clarified, citric acid / Sodium citrate buffer is adjusted to the solution pH, passed through the filter (0.45 μm, 0.22 μm), and filtered, filtered, filtered, lyophilized.

Embodiment 2

[0029]Take hydroxypropyl-β-cyclodextrin 0.6 g is dissolved in 100 ml of water, continuously stirred until the solution is clarified, add 0.9 g of sodium chloride, add mitmithicillin C 0.2g, continuously stirred until the solution is clarified, citric acid / Sodium citrate buffer is adjusted to the solution pH, passed through the filter (0.45 μm, 0.22 μm), and filtered, filtered, filtered, lyophilized.

Embodiment 3

[0031]Take hydroxypropyl-β-cyclodextrin 0.9 g is dissolved in 100 ml of water, continuously stirred until the solution is clarified, add 0.9 g of sodium sodium chloride, add mitomycin C 0.3g, continuously stirred until the solution is clarified, citric acid / Sodium citrate buffer is adjusted to the solution pH, passed through the filter (0.45 μm, 0.22 μm), and filtered, filtered, filtered, lyophilized.

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Abstract

The invention provides a preparation method of an ophthalmic preparation of mitomycin C. The preparation method comprises the following steps: inclusion is carried out on mitomycin C by using hydroxypropyl-beta-cyclodextrin or a derivative thereof, the water solubility of mitomycin C is improved, an osmotic pressure regulator is added, and the solution is freeze-dried, so that the stability of the ophthalmic preparation is improved.

Description

Technical field[0001]The invention belongs to the field of medicine and chemical chemical, and more particularly to a method of preparing a stable tantamicin C eye formulation.Background technique[0002]Mitmithicillin C, MITOMYCIN C) An anti-metabolic drug, is an anti-tumor antibiotic separated from the head streptomalates, crosslinking with DNA, destroying the structure and function of DNA, inhibiting The replication of the proliferative DNA has a killing of cells in the proliferative period, and also acts on the stationary cells, and thus can be used to prevent the blood vessel regeneration in the operating area. The structural formula is:[0003][0004]The main purpose of glaucoma eye filtration surgery is to establish a new ribbon water drainage pathway. It is an important method for the treatment of glaucoma, but some patients have filtering difficult to form, surgery fail. Its main reason is that the surgical zone and the fibroblasts are excessive hyperplasia, fibrosis, and scar f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K47/69A61K31/407A61P27/02
CPCA61K9/19A61K31/407A61K47/6951A61P27/02
Inventor 操锋阚成琳
Owner JIANGSU JINGLIXIN PHARMA TECH CO LTD
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