Hydrogen peroxide and nano-silver compound hand disinfectant and preparation method thereof

A technology of hydrogen peroxide and nano-silver, which is applied in the direction of active ingredients of peroxides, pharmaceutical formulas, medical preparations of non-active ingredients, etc., can solve problems such as easy foaming compounding, inability to sustain effective antibacterial, peeling, etc., to achieve Reduce the decomposition rate, prolong the shelf life of storage, and stabilize the system

Active Publication Date: 2021-06-04
海韵一剑大卫生科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The bactericidal ingredients commonly used in existing hand disinfection products mainly include volatile alcohols such as ethanol, isopropanol, n-propanol, hydrogen peroxide complex alcohols, chlorine Hexidine and plant-extracted bactericidal ingredients, all kinds of hand disinfectants have their shortcomings or limitations; the most common quick-drying alcohol disinfectants will take away the moisture on the skin when they volatilize, high concentrations of ethanol, n-propyl Alcohol or isopropanol will also decompose the sebum of the hands, and frequent use will cause the skin of the user's hands to be degreased, dry, rough, or even peeled and chapped, causing pain and injury to the user; quaternary ammonium salt disinfectants are Its components are cationic surfactants, which are easy to foam and have many restrictions on compounding with other components; hydrogen peroxide hand sanitizers usually use hydrogen peroxide with a content of about 1% as the bactericidal concentration, but this concentration of hydrogen peroxide is single The composition is difficult to meet the requirements of hand disinfection, and it needs to be compounded with high-concentration alcohols or other disinfection ingredients to achieve the disinfection effect; currently there are hand disinfection products on the market that use silver ions as the main disinfection ingredient, but the silver ion itself loses one or multiple electrons, which have strong oxidative properties and cause certain damage to skin cells, and lose the antibacterial effect after sterilization, and cannot continue to effectively antibacterial
The hand sanitizers on the market have no irritation to the skin, little damage, refreshing, moisturizing and continuous effective antibacterial.
[0004] Comparative Document 1-A hydrogen peroxide silver ion compound disinfectant is described as a compound disinfectant of hydrogen peroxide and silver ion, by adding gelatin, Form gelatin-silver ion complexes to improve the stability of silver ions, but fail to solve the problem of long-term effective antibacterial effect of disinfectants

Method used

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  • Hydrogen peroxide and nano-silver compound hand disinfectant and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0043] On the basis of disclosed embodiments, preferably disclose a kind of hydrogen peroxide and nano-silver compound hand disinfectant and its preparation method embodiment:

[0044] (1) Add 0.4g of phytic acid, 0.03g of oxidized glutathione, 0.5g of sodium pyrophosphate and 0.2g of hydroxyethylidene diphosphonic acid in sequence to 50g of deionized water, and stir until completely dissolved;

[0045] (2) Add 2 g of hydrogen peroxide solution with an initial concentration of 50% to the product in step (1), and stir evenly;

[0046] (3) Quantitatively weigh 5g of nano-silver with an initial concentration of 2000mg / L, 1.0g of 1,3-butanediol, 0.05g of phenoxyethanol, 2.0g of glycerin, 0.08g of hyaluronic acid and 2g of chamomile extract and add (2 ) step product, add deionized water to the required quality, and continue to stir for 30 minutes until all solid substances are dissolved.

[0047] Microbial killing test, bacteriostasis test and stability test were carried out accor...

Embodiment 2

[0049] On the basis of disclosed embodiments, preferably disclose a kind of hydrogen peroxide and nano-silver compound hand disinfectant and its preparation method embodiment:

[0050] (1) Add 0.7g phytic acid, 0.05g oxidized glutathione and 0.5g sodium hexametaphosphate to 50g deionized water successively, and stir until completely dissolved;

[0051] (2) Add 2 g of hydrogen peroxide solution with an initial concentration of 50% to the product in step (1), and stir evenly;

[0052] (3) Quantitatively weigh 4g of nano-silver with an initial concentration of 2000mg / L, 1.0g of 1,3-butanediol, 1.0g of phenoxyethanol, 1g of propylene glycol, 3g of glycerin, 0.02g of polyglutamic acid and 1g of witch hazel Add the extract to the product of step (2), make up to the required quality with deionized water, and continue stirring for 30 minutes until all solid substances are dissolved.

[0053] Microbial killing test, bacteriostasis test and stability test were carried out according to ...

Embodiment 3

[0055] On the basis of disclosed embodiments, preferably disclose a kind of hydrogen peroxide and nano-silver compound hand disinfectant and its preparation method embodiment:

[0056] (1) Add 0.8 g of phytic acid, 0.01 g of oxidized glutathione, 0.5 g of sodium pyrophosphate, and 0.2 g of sodium stannate to 50 g of deionized water in sequence, and stir until completely dissolved;

[0057] (2) Add 2 g of hydrogen peroxide solution with an initial concentration of 50% to the product in step (1), and stir evenly;

[0058] (3) Quantitatively weigh 3g of nano-silver with an initial concentration of 2000mg / L, 0.5g of 1,3-butanediol, 0.5g of phenoxyethanol, 0.5g of amino acid humectant, 0.5g of propylene glycol and 5g of chamomile extract and add (2 ) step product, add deionized water to the required quality, and continue to stir for 30 minutes until all solid substances are dissolved.

[0059] Microbial killing test, bacteriostasis test and stability test were carried out accordin...

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Abstract

The invention provides a hydrogen peroxide and nano-silver compound hand disinfectant and a preparation method thereof, and belongs to the technical field of disinfection. The hydrogen peroxide and nano-silver compound hand disinfectant comprises, by mass, 0-1.5% of hydrogen peroxide, nano-silver with an effective mass concentration of 50-100 mg / L, 0.1-2% of a stabilizer, 0.1-5% of a synergistic auxiliary agent, 0.05-5% of a moisturizing component and 1-10% of a plant skin care and sterilization component. ,According to the disinfectant, an alcohol-free formula is adopted, hydrogen peroxide and nano-silver are selected and compounded, the hydrogen peroxide and the nano-silver synergistically sterilize, the system is stable, the hydrogen peroxide is free of toxicity and residues after being decomposed, the nano-silver can form an antibacterial protective film to sterilize continuously and is free of irritation and damage to skin, the problems that the hand disinfectant in the market is non-irritant to the skin, small in damage and difficult to meet the requirements of refreshing, moisturizing and continuously and effectively resisting bacteria at the same time are solved, and the hand disinfectant has a wide application prospect in the technical field of disinfection.

Description

technical field [0001] The invention relates to a hydrogen peroxide and nano-silver compound hand disinfectant and a preparation method thereof, belonging to the technical field of disinfection. Background technique [0002] The inventor finds that there are at least the following problems in the prior art: [0003] The commonly used bactericidal ingredients in existing hand disinfection products mainly include volatile alcohols such as ethanol, isopropanol, and n-propanol, hydrogen peroxide complex alcohols, chlorhexidine, and plant-extracted bactericidal ingredients. Each has its disadvantages or limitations; the most common quick-drying alcohol-based disinfectants will take away moisture from the skin as they evaporate, and high concentrations of ethanol, n-propanol, or isopropanol will also break down sebum on the hands, and frequent use It will cause the user's hand skin to be degreased, dry, rough, or even peeled and chapped, causing pain and injury to the user; qua...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/40A61K33/38A61K36/185A61K36/28A61K36/886A61K36/896A61K47/10A61K47/26A61K47/32A61K47/34A61K47/36A61P17/00A61P31/04
CPCA61K33/40A61K33/38A61K36/185A61K36/28A61K36/896A61K36/886A61K47/10A61K47/26A61K47/36A61K47/34A61K47/32A61P17/00A61P31/04A61K2300/00
Inventor 孙道鸣其他发明人请求不公开姓名
Owner 海韵一剑大卫生科技有限公司
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