Application of aspartic acid in preventing or treating obesity

A technology of aspartic acid and obesity, applied in the field of biomedicine, can solve the problems of gastrointestinal tract, adverse reactions, and affecting the absorption of fat-soluble vitamins in patients

Inactive Publication Date: 2021-06-08
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drugs that inhibit intestinal lipid absorption, such as intestinal lipase inhibitor orlistat, can reduce fat absorption by about 30%, but it is easy to affect the absorption of fat-soluble vitamins in patients, and there are adverse reactions in the gastrointestinal tract, which may lead to severe Liver damage; drugs that regulate the nerve center to suppress appetite, such as central appetite inhibitors phentermine/topiramate, naltrexone/bupropion hydrochloride all act on the hypothalamus appetite regulation pathway to reduce appetite, but there is a risk of addiction and central side effects; drugs that promote energy metabolism, such as peripheral appetite suppressant liraglutide, are

Method used

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  • Application of aspartic acid in preventing or treating obesity
  • Application of aspartic acid in preventing or treating obesity
  • Application of aspartic acid in preventing or treating obesity

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Embodiment Construction

[0031] In order to make the object, technical solution and technical effect of the present invention clearer, the present invention will be further described in detail below in conjunction with specific embodiments. It should be understood that the specific implementations described in this specification are only for explaining the present invention, not for limiting the present invention.

[0032] The experimental materials and reagents used, unless otherwise specified, are conventional consumables and reagents that can be obtained from commercial channels.

[0033] Experimental Materials

[0034] Preparation of differentiation induction medium:

[0035] (1) The formula of differentiation induction medium I was as follows: 3-isobutyl-1-methyl-xanthine, 100 ng / mL dexamethasone and 2 μg / mL insulin were added to the DMEM complete culture medium at a final concentration of 500 μM.

[0036] (2) The formula of differentiation induction medium II is: add insulin with a final conce...

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Abstract

The invention discloses application of aspartic acid in preventing or treating obesity. The aspartic acid is L-aspartame, and the usage amount of the L-aspartame is 40-200 microns. The inventor finds that the L-aspartame has the effects of inhibiting adipogenesis, reducing triglyceride level in fat cells, effectively controlling the level of glucose, insulin and free fatty acid in vivo, reducing the content of total fat tissues and fat tissues at each part, and inhibiting fat cell maturation, so that the L-aspartame has potential medicinal value for effectively preventing or treating obesity.

Description

technical field [0001] The invention belongs to the field of biomedicine, and specifically relates to the application of aspartic acid in preventing or treating obesity. Background technique [0002] The occurrence of obesity is due to the imbalance between energy intake and energy consumption in the body, resulting in excessive fat hyperplasia and abnormal accumulation. In recent years, obesity has become a major health problem worldwide. About 2.1 billion people in the world are overweight or obese. The incidence of overweight in adults is 28.1%, and the incidence of obesity is 5.2%. Related technical studies have shown that obesity may lead to various complications, such as non-alcoholic fatty liver disease (NAFLD), cardiovascular and cerebrovascular diseases, hypertension, type 2 diabetes (type 2diabetes, T2D), cancer etc., seriously endangering human health. [0003] In the related art, obesity treatment methods are very limited. At present, the treatment of obesity ...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61P3/04
CPCA61K31/198A61P3/04
Inventor 黄志纾饶勇陆勇军郭诗瑶邝芷琪
Owner SUN YAT SEN UNIV
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