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Alpinia katsumadai composition for preventing and treating alopecia

A composition, the technology of cardamom grass, applied in the field of medicine, can solve the problems of easy relapse and side effects after drug withdrawal

Active Publication Date: 2021-06-08
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the US FDA has only approved two drugs for the treatment of androgenetic alopecia: minoxidil tincture for men and women and oral finasteride tablets for men only, both of which have significant side effects and require withdrawal Easy to relapse

Method used

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  • Alpinia katsumadai composition for preventing and treating alopecia
  • Alpinia katsumadai composition for preventing and treating alopecia
  • Alpinia katsumadai composition for preventing and treating alopecia

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Embodiment 1

[0024] 1. Experimental materials

[0025] 1.1 Medicinal materials

[0026] Testosterone (CAS: 58-22-0, molecular weight 288.42, HPLC purity ≥ 98%, produced by Sigma-Aldrich Company of the United States); Cardamom officinalis extract; Pyrrolidinyl diaminopyrimidine oxide (abbreviated PDO, CAS: 55921-65 -8, molecular formula C8H13N5O, molecular weight 195.22, HPLC purity ≥ 98%, Beijing Wokai Biotechnology Co., Ltd.)

[0027] 1.2 Experimental animals

[0028] C57BL / 6 male mice (8 weeks) weighing 20±2 g were provided by the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine, animal certificate number: SYXK (Shanghai) 2009-0069. Placed in a conventional feeding environment, free access to food and water.

[0029] 2. Experimental method

[0030] 2.1 Preparation of pyrrolidinyl diaminopyrimidine oxide and cardamom grass extract composition external paint

[0031] (1) Preparation method of cardamom extract: take cardamom medicinal material, add 10 t...

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PUM

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Abstract

The invention relates to the field of medicine and pharmacology, in particular to a composition for preventing and treating alopecia and application thereof. The composition is prepared from pyrrolidinyl diaminopyrimidine oxide and alpinia katsumadai extract according to the weight ratio of 9: 1-1: 9, and the alpinia katsumadai extract can be prepared through the following steps: taking alpinia katsumadai medicinal materials, adding 10 times of distilled water, soaking for 1 h, heating and decocting for 30 min, filtering through gauze, saving the filtrate, adding 6 times of the distilled water into medicine residues, and soaking, decocting and filtering by the same method; and mixing the two filtrates, freezing, drying and crushing. The composition can be used for preventing and treating androgenetic alopecia.

Description

technical field [0001] The invention belongs to the field of medicine. Specifically relates to a composition for preventing and treating hair loss. Background technique [0002] Hair loss has a significant impact on an individual's mental health and quality of life, and is a source of low self-esteem and anxiety for many patients, leading to depression in severe cases. The hair that falls out normally is the hair in the catagen and telogen phases. Since the hairs entering the catagen and growth phases are constantly in a dynamic balance, a normal amount of hair can be maintained. Pathological alopecia refers to abnormal or excessive shedding of hair. Factors leading to pathological alopecia include heredity, mental stress, autoimmunity, acute and chronic infectious diseases, various skin diseases, endocrine disorders, and toxic side effects of chemotherapy. Androgenetic alopecia (androgenetic alopecia, AGA), also known as seborrheic alopecia, belongs to pathological alopec...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61P17/14A61K8/9794A61K8/49A61Q5/02A61Q5/12A61Q7/00A23L33/105A23L33/10A61K31/506
CPCA61K36/9062A61K31/506A61P17/14A61K8/9794A61K8/4953A61Q5/02A61Q5/12A61Q7/00A23L33/105A23L33/10A61K2800/592A23V2002/00A61K2300/00A23V2250/21A23V2200/318
Inventor 窦薇于之伦岳备王浩耿小龙高瑞阳王峥涛
Owner SHANGHAI UNIV OF T C M