Preparation method of sugammadex sodium injection

A technology of sugammadex sodium injection, which is applied in the field of preparation of sugammadex sodium injection, to achieve the effects of increasing safety, reducing catalysis, and inhibiting the production of impurities
CN112933040APending Publication Date: 2021-06-11HEFEI BOSIKC PHARMTECH CO LTD
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
HEFEI BOSIKC PHARMTECH CO LTD
Publication Date
2021-06-11

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Abstract

The invention discloses a preparation method of a sugammadex sodium injection, which comprises the following steps: preparing the sugammadex sodium injection under the protection of inert gas, adding a protective agent in the preparation process, coarsely filtering a liquid medicine, and removing the residual protective agent through a reverse osmosis membrane, wherein the protective agent is selected from phosphoinositide and derivatives thereof. The sugammadex sodium injection has good economical efficiency and is more suitable for industrial production, and the prepared sugammadex sodium injection is better in quality, safer and more stable.
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Description

technical field

[0001] The invention relates to a pharmaceutical preparation technology, in particular to a preparation method of sugammadex sodium injection. Background technique

[0002] About 20 million patients receive general anesthesia every year in China. During the whole process of preoperative anesthesia, intraoperative sleep, and postoperative recovery, patients usually need three types of drugs, such as sedatives, analgesics, and muscle relaxants, to work together to reverse the patient's functional state in due course.

[0003] Muscle relaxants represented by rocuronium bromide are commonly used as adjuvant drugs for anesthesia in surgical operations. They are used for tracheal intubation during routine induction of anesthesia and for maintaining skeletal muscle relaxation during surgery. However, after the operation, it is necessary to quickly reverse the patient's muscle relaxation state to restore spontaneous breathing and muscle function, so as to avoid comp...

Claims

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