Novel chromatographic column and discharging method

Abstract

The invention provides a novel chromatographic column which comprises a chromatographic column inlet, a column cylinder, a chromatographic column outlet, a sight glass, a vacuum material suction device, a gas heater, a vacuum conveyor and the like, meanwhile, the invention provides a method for unloading filler by using the chromatographic column, and when the chromatographic column and the method provided by the invention are used for unloading the filler, a column bed does not need to be scattered firstly, and alower end cover does not need to be detached, so that the labor intensity of an operator is reduced, and the operation time is shortened. The whole filler unloading process is in a closed state, and pungent smell of solvent volatilization and flammable and explosive phenomena are avoided.

Description

technical field [0001] The invention relates to a novel chromatographic column and a material unloading method, belonging to the field of chromatography. Background technique [0002] Chromatographic column is an important equipment for the chromatography industry to purify process liquids and separate required substances from process liquids. During separation, the mobile phase carrying the sample is forced to move within the column bed through the granular media of the stationary phase driven by pressure. Since different compounds will have different mobility through the medium, different samples in the mobile phase flow out of the column sequentially. However, if the column head of the chromatography column collapses or the filler fails, or the chromatography column needs to replace the filler, it is necessary to take out the filler, replace the filler and repack the column. There are usually two methods in the prior art. The first method is to break up the column bed w...

AI Technical Summary

Problems solved by technology

The first method needs to pass compressed gas through the filter plate above the lower end cover or flow it to break up the column bed. Since the compressed gas or mobile phase passes through the filter plate, the filter plate will be deformed, and the filter plate will be damaged if it is used frequently. For packing materials that are prone to caking, the column bed cannot be broken up by this method

The second method is used for packings that are easy to agglomerate. It is necessary to remove the lower end cap first, which increases the labor intensity of the operator, and because the mobile phase used for separation is usually a solvent with a pungent odor, when the end cap is removed, the outside world Direct gas communication will be full of pungent odors and flammable and explosive gases and liquids

Thus affecting the health of the operator, and even an explosion causing a major safety accident

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