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Compound pharmaceutical composition and application thereof

A composition and drug technology, applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems that the therapeutic effect of the composition needs to be further improved, and the comprehensive curative effect needs to be improved, so as to achieve the effect of protecting from damage and improving the protective effect

Active Publication Date: 2021-07-23
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Panax notoginseng saponins and ferulic acid have certain curative effects on cardiovascular and cerebrovascular diseases and diabetic complications, their comprehensive curative effect needs to be improved
But the therapeutic effect of the composition prepared by this patent application still needs to be further improved

Method used

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  • Compound pharmaceutical composition and application thereof
  • Compound pharmaceutical composition and application thereof
  • Compound pharmaceutical composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] A compound pharmaceutical composition comprises the following components in parts by weight: 5 parts of total alkaloids of coptis, 5 parts of total saponins of astragalus and 1 part of total saponins of Panax notoginseng.

[0045] The preparation method of the total alkaloids of Coptidis rhizome comprises the following steps: Extract the coarse powder of Coptis rhizome with 80% (v / v) ethanol at 25° C. for 24 hours at 1 times the amount (the ratio of solid to liquid is 1 g / mL), and extract 3 Once, the extracted supernatant was collected and evaporated to dryness under a rotary evaporator to obtain the total alkaloids of Coptidis rhizome.

Embodiment 2

[0047] A compound pharmaceutical composition comprises the following components in parts by weight: 10 parts of total alkaloids of coptis, 10 parts of total saponins of astragalus and 3 parts of total saponins of Panax notoginseng.

[0048] The preparation method of the total alkaloids of Coptidis rhizome comprises the following steps: Extract the coarse powder of Coptidis Rhizoma with 75% (v / v) ethanol in an amount of 1.2 times (solid-liquid ratio: 1:1.2g / mL) at 30°C for 30h, Methods Extracted 4 times, collected the extracted supernatant, and evaporated to dryness under a rotary evaporator to obtain the total alkaloids of Coptidis rhizome.

Embodiment 3

[0050] A compound medicinal composition comprises the following components in parts by weight: 8 parts of total alkaloids of coptis, 8 parts of total saponins of astragalus and 2 parts of total saponins of Panax notoginseng.

[0051] The preparation method of the total alkaloids of Coptis chinensis comprises the following steps: Extract the coarse powder of Coptis chinensis with 85% (v / v) ethanol at 20° C. for 20 h at 20° C. Methods Extracted twice, collected the extracted supernatant, and evaporated to dryness under a rotary evaporator to obtain the total alkaloids of Coptis chinensis.

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Abstract

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a compound pharmaceutical composition and application thereof. The compound pharmaceutical composition comprises the following components: total alkaloids of coptis chinensis, total saponins of astragalus membranaceus and total saponins of panax notoginseng. The compound pharmaceutical composition has the advantages of remarkable effect and small side effect in treating cardiovascular and cerebrovascular diseases and diabetic complications.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a compound medicinal composition and its application. Background technique [0002] Astragalus is a traditional Chinese medicine that strengthens qi, strengthens the surface, protects the heart, and improves the immune function of the body. It mainly contains saponins, polysaccharides, in addition to amino acids, flavonoids and other ingredients. Astragalus saponins can improve myocardial contractile function, reduce myocardial infarction area, and reduce myocardial damage to dogs with acute infarction; astragalosides can effectively improve myocardial ischemia, protect cardiovascular and cerebrovascular, and improve cardiac microcirculation. Its main active ingredient is astragaloside IV. The content of astragaloside in the existing astragalus medicinal material is very low, about 0.04%. The existing Astragalus injection has a strong effect of invigorati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61P9/00A61P25/00A61P3/10A61P9/10A61P7/02A61P11/00A61P13/12
CPCA61K36/718A61K36/481A61K36/258A61P9/00A61P25/00A61P3/10A61P9/10A61P7/02A61P11/00A61P13/12A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 张晶晶杨洪军周瑞
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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