Bacteriostatic temperature-sensitive gel, and preparation method and application thereof

Abstract

The invention provides antibacterial temperature-sensitive gel. The antibacterial temperature-sensitive gel is prepared from the following ingredients in percentage by mass: 15 to 30 percent of traditional Chinese medicine stock solution, 3 to 15 percent of clove oil, 0.2 to 0.5 percent of chlorhexidine acetate, 9 to 12 percent of glycerol, 3 to 6 percent of Tween 80, 15 to 25 percent of poloxamer 407, 1 to 3 percent of poloxamer 188, 3 to 6 percent of hydroxypropyl methyl cellulose, 3 to 5 percent of ethanol and 0.2 to 2 percent of silver nitrate, wherein the traditional Chinese medicine stock solution is prepared from the following raw material ingredients in parts by weight: 30 to 55 weight parts of radix scutellariae, 45 to 55 parts of radix et rhizoma rhei, 45 to 55 parts of cortex phellodendri and 45 to 55 parts of herba portulacae. The invention also provides a preparation method and application of the antibacterial temperature-sensitive gel. The antibacterial temperature-sensitive gel disclosed by the invention can be applied in a liquid state, can be uniformly applied to an acting surface, avoids drug application dead corners, can be changed into semi-solid gel, forms high-viscosity difficult-to-flow semi-solid state gel, prolongs the drug action time, and achieves the antibacterial and anti-inflammatory effects on skin, orifices and deep tissues to the greatest extent.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a bacteriostatic thermosensitive gel and a preparation method and application thereof. Background technique [0002] Nowadays, with the increasing development and progress of society, people communicate more frequently and extensively, and the ways of communication are more diverse, which also brings new social and health problems, such as women's infection caused by microorganisms or sexual intercourse. The possibility of gynecological diseases (such as trichomonal vaginitis, candida vaginitis, chronic cervicitis, senile vaginitis, pelvic inflammatory disease, etc.) caused by contact will greatly increase, which seriously threatens the health of female friends. Such gynecological diseases are often caused by trichomonas, fungus or bacterial infection, and can also be caused by mixed infection; and the treatment of these diseases is mainly based on vaginal topical ad...

AI Technical Summary

Problems solved by technology

The lotion is a liquid preparation. Although the lotion can wash the vagina, it is easy to lose and the local action time is short, which makes the local anti-inflammatory and bactericidal effects poor. It needs a large dose of multiple administrations to achieve a good therapeutic effect, and often Changing the internal environment of the vagina is likely to cause repeated infections; suppositories can stay in the affected area for a long time, but they are administered in solid form, and the patient has a foreign body sensation, poor compliance, and inconvenient to use; gels are administered in semi-solid form, but The contact distribution between the drug and the patient's tissue is uneven, there is a dead angle for the drug, and the ordinary gel has low gel strength and poor bioadhesion, resulting in a short local action time and limiting the full use of the drug's curative effect; effervescent tablets can solve half of the problem. Solid and solid preparations are unevenly dispersed and there are problems of drug dead ends, but their local action time is too short, and a large amount of discharge contaminates clothes; film preparations have slow-release characteristics, which can solve the problem of short drug action time, but patients have a foreign body sensation , Poor patient adaptability, uneven coating and inconvenient administration

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