Method for predicting healthy aging through relative abundance of intestinal flora

A technology of relative abundance and intestinal flora, applied in biochemical equipment and methods, microbial determination/inspection, etc., can solve the problem of inability to distinguish intestinal flora, and achieve convenient detection, harmless operation, and easy operation. Effect

Active Publication Date: 2021-07-30
ZHONGSHAN HOSPITAL FUDAN UNIV
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Problems solved by technology

In addition, there are relatively few literatures on the characteristics of the intestinal flora of healthy elderly people in China, especially the elderly, and we have not yet been able to distinguish the intestinal flora of healthy elderly people from other age groups, which indicates that healthy Necessity of research on intestinal flora of the elderly
At present, there is a lack of effective predictive biomarkers for healthy aging clinically. The present invention identifies changes in the relative abundance of intestinal flora related to healthy aging, and provides a method for predicting health through the relative abundance of intestinal flora. Methods of Sexual Aging

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  • Method for predicting healthy aging through relative abundance of intestinal flora
  • Method for predicting healthy aging through relative abundance of intestinal flora
  • Method for predicting healthy aging through relative abundance of intestinal flora

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Embodiment Construction

[0023] In order to make the present invention more obvious, it is described in the preferred embodiment, and the accompanying drawings is described in detail below:

[0024] The present invention provides a method of predicting health aging through intestinal flora, including the following steps:

[0025] Step 1. Select the average group of Shanghai, including the healthy centenarians (average age 99), more old (an average age 88) and young adults (average age 42 years old), one of whom is recognized Health aging and longevity model. The cleaning of all people was collected by 0.1 g, and immediately placed on ice after placing in a sterile centrifuge tube, transferred to -80 ° C for 2 hours. Use an Omega DNA kit to extract the feces genome total DNA in accordance with the specification. The PCR product was subjected to MISEQPE 2x300 bp high-throughput sequencing by the ILLUMINA MISEQ high-throughput sequencing platform PE 300. Variable region of the intestinal flora DNA. The seque...

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Abstract

The invention relates to a method for predicting healthy aging through relative abundance of intestinal flora, and belongs to the technical field of elderly medicine. The composition characteristics of the taxonomy level of the intestinal flora of the elderly are studied through a high-throughput sequencing method, and the obviously different intestinal flora in the 100-year old, the elderly and the young adults is analyzed and used as a detection index for predicting healthy aging. Six kinds of intestinal microorganisms are used for predicting healthy aging. According to the method, the intestinal microorganisms for predicting healthy aging are screened out according to the abundance of the differential intestinal flora of the 100-year old, the elderly and the young adults, and new indexes and basis are provided for health aging detection of the whole people.

Description

Technical field [0001] The present invention relates to a method of predicting health aging through intestinal flora, belonging to the technical field of senile medicine. Background technique [0002] Population aging is not only the challenges facing developed countries, but also the severe challenges facing developing countries, especially China. So how to make our people can be healthier, reducing the burden of national and society, this is a very important social and medical problems. [0003] Intestinal microorganisms are not only parasitic microorganisms in human body and animal gastrointestinal tract, but also symbiotic bacteria affecting humans and animals, synergistic evolution. More and more studies have found that intestinal flora is not only involved in the nutrients of host, glycolipid metabolism, resist inflammation and regulatory immunity, but also closely related to aging. The study found that the intestinal flora showd a significant change in aging: the number of...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/689C12Q1/6869
CPCC12Q1/689C12Q1/6869C12Q2535/122
Inventor 邬佳瑜胡予任卫英
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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