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Application of small molecule compound in preparation of medicine for resisting central nervous system inflammation

A technology of small molecular compounds and central nervous system, applied in the field of medicine, can solve the problems of unsatisfactory drug conditions, large side effects, poor pharmacokinetic properties, etc., and achieve the effect of good development prospects and low cytotoxicity

Inactive Publication Date: 2021-08-06
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first discovered MIF inhibitor NAPQI has poor specificity and side effects
The pharmacokinetic properties of 4-IPP inhibitors are poor and do not meet the conditions for drug preparation

Method used

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  • Application of small molecule compound in preparation of medicine for resisting central nervous system inflammation
  • Application of small molecule compound in preparation of medicine for resisting central nervous system inflammation
  • Application of small molecule compound in preparation of medicine for resisting central nervous system inflammation

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Embodiment Construction

[0014] In order to make the above objects, features and advantages of the present invention more obvious and comprehensible, the technical solution of the present invention will be further described below in conjunction with the examples. But the present invention is not limited to the listed embodiments, but also includes any other known changes within the claimed scope of the present invention.

[0015] Reference herein to "one embodiment" or "an embodiment" refers to a particular feature, structure or characteristic that can be included in at least one implementation of the present invention. "In one embodiment" appearing in different places in this specification does not all refer to the same embodiment, nor is it a separate or selective embodiment that is mutually exclusive with other embodiments.

[0016] The present invention discovers the small molecular compound 6,8-difluoro-3-(4-methoxyphenyl)thieno[3,2-c]quinoline-2-carboxylic acid (hereinafter Compound #4 for shor...

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Abstract

The invention discloses application of a small molecule compound, the small molecule compound is 6, 8-difluoro-3-(4-methoxyphenyl) thieno [3, 2-c] quinoline-2-carboxylic acid, the chemical structural formula of the small molecule compound is shown in the specification, the small molecule compound has a relatively strong inhibition effect on MIF and has an obvious inhibition effect on microglial cell activation-mediated NO release, and the small molecule compound is relatively low in cytotoxicity and has a good development prospect, is expected to be developed into a novel MIF inhibitor, and is expected to be developed into a novel medicine for resisting central system inflammation.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to the application of a small molecular compound in the preparation of MIF inhibitors and anti-inflammation drugs of the central nervous system. Background technique [0002] Immune dysregulation in the central nervous system is a key factor in the development of various nervous system diseases. Microglia are the main immune cells of the nervous system, and they serve as the first line of defense to monitor stimuli such as pathogen infection and neuron damage at any time. Resting microglia can be activated into classically activated M1 or selectively activated M2. M1 microglia secrete iNOS, TNF-α, ROS and other pro-inflammatory factors, which play an important role in the clearance of pathogens in the brain. M2 microglia secrete IL-10, TGF-α and other anti-inflammatory factors to reduce inflammation and promote tissue repair. Inflammatory activation of microglia and c...

Claims

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Application Information

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IPC IPC(8): A61K31/4743A61P25/00A61P29/00
CPCA61K31/4743A61P25/00A61P29/00
Inventor 镇学初田盛刘纯
Owner SUZHOU UNIV
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