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System for non-invasively evaluating intrauterine nutrition status of newborn and application thereof

A nutritional status, non-invasive technology, applied in the direction of biological testing, instruments, measuring devices, etc., to achieve the effect of overcoming neonatal injury and precise nutritional intervention

Active Publication Date: 2021-08-06
国家卫生健康委科学技术研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In conclusion, current methods for assessing neonatal nutrition have limitations, and efforts are still needed to find accurate and non-invasive evaluation methods

Method used

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  • System for non-invasively evaluating intrauterine nutrition status of newborn and application thereof
  • System for non-invasively evaluating intrauterine nutrition status of newborn and application thereof
  • System for non-invasively evaluating intrauterine nutrition status of newborn and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 Participant Recruitment and Sample Collection

[0018] 1. Participant Recruitment and Sample Collection

[0019] The initial selection criteria for infants to be included in the study were as follows. (1) live-born singleton infants with a gestational age greater than or equal to 38 weeks and an Apgar score greater than 8; (2) only infants with a hospital stay of more than 24 hours were included; (3) known gestational age (at gestational age 14 Reliable ultrasound for measurement of crown-rump length before 14-20 weeks of gestation or for measurement of twin diameter at the start of antenatal care between 14 and 20 weeks of gestation). After strict and standardized operating procedures, each hospital agreed to the policy of routinely using ultrasound to estimate gestational age. To ensure the accuracy of gestational age, the last last menstrual period was used as reference in addition to ultrasound estimates. The difference between the estimated gestational...

Embodiment 2

[0033] Example 2. Evaluation of nutrients accumulated in the womb of newborns by simple physical / chemical characteristics of meconium.

[0034] 1. Physical / chemical properties of meconium

[0035] The meconium weight of malnourished newborns is between 0.20g and 8.65g, with an average weight of 1.4g; The pH ranges from 4.29 to 8.53 with an average of 5.9. The pH value of meconium in malnourished newborns was between 4.36 and 7.45; in addition, the water content of meconium in well-nourished newborns was 41.67%-93.67%, and the water content of meconium in malnourished newborns was 4.28%-92.53%.

[0036] 2. Physical and chemical properties of meconium

[0037] 2.1. Statistical analysis of meconium color

[0038]The color of meconium was recorded according to the meconium grading standard card, and the statistical significance was analyzed by Chi-square test. There was no statistical significance between the two groups (P>0.05).

[0039] 2.2. Statistical analysis of meconium...

Embodiment 3

[0045] Example 3. Evaluation of neonatal nutrition in utero by analysis of meconium metabolome

[0046] 1. Pretreatment of meconium

[0047] With grinding beads, 150 μL of acetonitrile was added to 10 mg of meconium, and the mixture was then ground by bead milling (25 Hz x 1 min x 2 times). Put 120 μL of the homogenate into an EP tube and vortex for 30 s. Then centrifuge at 14,000 rpm for 10 minutes at 4°C. The supernatant was obtained, and the internal labeling solution was added to the supernatant, and then freeze-dried for LC-MS analysis.

[0048] 2. Metabolomic analysis of meconium

[0049] Meconium metabolism profiles were obtained using a Waters Acquity ultra-performance liquid chromatography (UPLC) coupled to a Waters Q-TOF Premier mass spectrometer (Waters Corp., Milford, MA, USA). Chromatographic separation was performed on a Waters BEH C8 column (50 mm x 2.1 mm, 1.7 μm) (Waters, Milford, MA) in positive ion mode. Mobile phase A was water with 0.1% formic acid an...

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Abstract

The invention provides a system for non-invasively evaluating the intrauterine nutrition status of a newborn and application thereof. The system is used for analyzing the composition change of compounds in fetal feces of the newborn. The invention provides a brand-new non-invasive system and method for evaluating the intrauterine nutrition status of the newborn for the first time, and the method can quickly and conveniently evaluate the intrauterine nutrition status of the newborn in a non-invasive mode.

Description

technical field [0001] The invention relates to the field of infant hygiene and health, in particular to a system for non-invasively evaluating the nutritional status of newborns in utero and its application. Background technique [0002] At present, the World Health Organization (WHO) evaluates the growth of newborns in the womb and evaluates the growth and nutrition of children. The Z-score system is based on anthropometric measurements, and the indicators involved are newborn weight by gestational age and sex, Body length and head circumference. However, methods for assessing nutritional accumulation in newborns in utero are limited. Birth weight and length are known to be influenced by a variety of factors, such as race, maternal size, pre-pregnancy weight, parity, altitude, and others. Body weight cannot distinguish between fat deposits and tissue water. In addition, body length cannot be measured precisely, and the accuracy of body length and head measurements is mu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/86G01N33/48
CPCG01N30/02G01N33/48G01N2030/027G01N30/72G01N30/8696Y02A90/10
Inventor 徐祥波陈西华贺斌庄太凤乔光莉刘建兵王树芳
Owner 国家卫生健康委科学技术研究所
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