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Wavelength-adjustable near-infrared second window long afterglow nanoprobe and synthesis method thereof

A technology of nanoprobes and synthesis methods, applied in nanotechnology, nanotechnology, nanooptics, etc., can solve problems such as limiting long afterglow probes, avoid background noise in biological tissues, improve resolution and signal-to-noise ratio, and widen The effect of the application foreground

Inactive Publication Date: 2021-08-10
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These problems limit the application of long afterglow probes in imaging analysis and detection in vivo

Method used

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  • Wavelength-adjustable near-infrared second window long afterglow nanoprobe and synthesis method thereof
  • Wavelength-adjustable near-infrared second window long afterglow nanoprobe and synthesis method thereof
  • Wavelength-adjustable near-infrared second window long afterglow nanoprobe and synthesis method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] NaYF 4 :1%Nd@NaYF 4 Preparation of near-infrared second window 1064 nm monochromatic emission long-persistence nanocrystals. Specific steps are as follows.

[0030] (1) Preparation of shell precursor; preparation of Y-OA (0.1 M) precursor: 5.0 mM YCl 3 Rare earth salts, 20.0 mL of OA and 30.0 mL of ODE were loaded into a 100 mL three-neck flask, and then heated to 140 °C under vacuum for 60 minutes; after cooling to room temperature, a 0.1 M clear and transparent Ln-OA precursor was obtained ;

[0031] Na-TFA-OA (0.4 M) precursor: put 20.0 mM Na-TFA rare earth salt, 50.0 mL of OA into a 100 mL three-necked flask, then heat to 70 °C under vacuum for 60 minutes; cool to room temperature After that, 0.4 M clear and transparent Na-TFA-OA precursor was obtained.

[0032] (2) NaYF 4 : Synthesis of 1%Nd Long Persistence Nanocrystalline Nuclei

[0033] First add 2 (1-0.01) mM YCl 3 and 0.02 mM NdCl 3 Added to a 100 mL three-neck flask containing 50.0 mL OA / ODE (volume ...

Embodiment 2

[0038] NaGdF 4 :3%Er@NaYF 4 Preparation of near-infrared second window 1525 nm monochromatic emission with long persistence nanocrystals. Specific steps are as follows.

[0039] (1) Preparation of shell precursor; preparation of Y-OA (0.1 M) precursor: 5.0 mM YCl 3 Rare earth salts, 20.0 mL of OA and 30.0 mL of ODE were loaded into a 100 mL three-neck flask, and then heated to 140 °C under vacuum for 60 minutes; after cooling to room temperature, a 0.1 M clear and transparent Ln-OA precursor was obtained ;

[0040] Na-TFA-OA (0.4 M) precursor: put 20.0 mM Na-TFA rare earth salt, 50.0 mL of OA into a 100 mL three-necked flask, then heat to 70 °C under vacuum for 60 minutes; cool to room temperature After that, 0.4 M clear and transparent Na-TFA-OA precursor was obtained.

[0041] (2) NaGdF 4 : Synthesis of 3% Er Long Persistence Nanocrystalline Nuclei

[0042] First add 2 (1-0.03) mM GdCl 3 and 0.06 mM ErCl 3 Added to a 100 mL three-neck flask containing 20.0 mL OA / ODE...

Embodiment 3

[0047] NaYF 4 :1%Nd,1%Ho,3%Er@NaGdF 4 Preparation of near-infrared second window 1064 nm, 1180 nm and 1525 nm three-color emission long-lasting nanocrystals. Specific steps are as follows.

[0048] (1) Preparation of shell precursor; preparation of Gd-OA (0.1 M) precursor: 5.0 mM GdCl 3 Rare earth salts, 20.0 mL of OA and 30.0 mL of ODE were loaded into a 100 mL three-neck flask, and then heated to 140 °C under vacuum for 60 minutes; after cooling to room temperature, a 0.1 M clear and transparent Ln-OA precursor was obtained ;

[0049] Na-TFA-OA (0.4 M) precursor: put 20.0 mM Na-TFA rare earth salt, 50.0 mL of OA into a 100 mL three-necked flask, then heat to 70°C under vacuum for 60 minutes; cool to room temperature After that, 0.4 M clear and transparent Na-TFA-OA precursor was obtained.

[0050] (2) NaYF 4 : Synthesis of 1%Nd, 1%Ho, 3%Er Long Persistence Nano-Crystal Nuclei

[0051] First add 2 (1-0.05) mM YCl 3 , 0.02 mM NdCl 3 , 0.02 mM HoCl 3 and 0.06 mM ErCl ...

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Abstract

The invention belongs to the technical field of nano biological materials, and particularly relates to a wavelength-adjustable near-infrared second window long afterglow nano probe and a synthesis method thereof. The long-afterglow nanoprobe is a nanocrystal with a core-shell structure, a long-afterglow luminous core layer is arranged inside the nanocrystal, and an inert shell layer is arranged outside the nanocrystal; the core layer is used for absorbing energy and emitting long afterglow signals; the inert shell layer is used for reducing the quenching effect of an external quenching group on a long afterglow signal. According to the invention, the long afterglow emission wavelength is adjusted by changing the doping type of rare earth ions; by changing the doping amount of rare earth ions, the size of a core layer and the thickness of a shell layer, the signal intensity and attenuation duration of long afterglow luminescence are adjusted. The long afterglow probe does not need to be excited in real time by an external light source, biological background noise caused by the external light source is avoided, and the resolution and the signal-to-noise ratio of biological imaging can be improved. The long afterglow probe has wide application prospects in the aspects of information coding and storage, multi-channel biological detection, living body imaging and analysis, surgical navigation and the like.

Description

technical field [0001] The invention belongs to the technical field of nano-biological materials, and in particular relates to a wavelength-adjustable near-infrared second window emitting long-lasting-glow nanoprobe and a synthesis method thereof. Background technique [0002] Due to the advantages of non-invasiveness, high sensitivity, high spatio-temporal resolution, and real-time convenience, fluorescence imaging is widely used in the fields of life science, clinical medicine, and biological imaging and analysis. However, how to improve the resolution, signal-to-noise ratio, and penetration depth of bio-optical imaging has always been a difficult problem for researchers to solve. Compared with visible light (400 nm-650 nm) and light in the first window of near-infrared light (650 nm-900 nm), biological tissues have smaller absorption of light in the second near-infrared window (1000 nm-1700 nm) and scattering. Therefore, the light in the second near-infrared window regi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/85C09K11/02B82Y20/00B82Y40/00G01N21/64A61K49/00
CPCC09K11/7773C09K11/7791C09K11/025B82Y20/00B82Y40/00G01N21/6428A61K49/0065A61K49/0017
Inventor 张凡裴鹏
Owner FUDAN UNIV
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