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Suture-free three-dimensional textile-based conductive myocardial patch and preparation method thereof

A textile-based, myocardial technology, applied in medical science, prosthesis, etc., can solve the problems of complex suture of myocardial patch, and achieve the effect of reducing postoperative complications, improving myocardial repair effect, and reducing the difficulty of surgery.

Inactive Publication Date: 2021-08-13
DONGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the complex suture problem of the prior art cardiac patch, and provide a suture-free three-dimensional textile-based conductive cardiac patch with a barbed structure and a preparation method thereof

Method used

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  • Suture-free three-dimensional textile-based conductive myocardial patch and preparation method thereof

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Effect test

Embodiment 1

[0031] A preparation method of a suture-free three-dimensional textile-based conductive myocardial patch, specifically as follows:

[0032] (1) prepare barbed short wire;

[0033] (1.1) Write a barbed short-line printing program;

[0034] Among them, the length of the short line is 2 mm, the diameter is 10 μm, one end of the short line is a beveled needle-point shape, and the other end is a plane; the angle between the beveled needle-pointed slope and the short line in the axial direction is 60°; the cross-sectional shape of the barb is circular; The barbs are located on the peripheral surface of the short line; the distance between adjacent barbs on the short line of the barb is 0.1mm, and the angle between the barb and the short line (trunk axis) is 60°; all the barbs are facing the end where the plane of the short line is located ; Along the axial direction of the short line, the barbs are distributed in rows, the number of barb rows is 1 row, and the angle between two adj...

Embodiment 2

[0043] A preparation method of a suture-free three-dimensional textile-based conductive myocardial patch, specifically as follows:

[0044] (1) prepare barbed short wire;

[0045] (1.1) The existing commercial polycaprolactone barbed suture is used as raw material; wherein, the diameter of the barbed suture is 26 μm; the cross-sectional shape of the barb is triangular; the barb is located at the center of the barbed suture (trunk axis) On the peripheral surface, and evenly arranged along a single direction; the distance between adjacent barbs of the barbed suture (trunk axis) is 0.2mm, and the angle between the barbs and the barb suture (trunk axis) is 60°;

[0046] (1.2) Cut the barbed suture into short lines with a length of 3mm; the two ends of the short lines are flat; along the axial direction of the short line, the barbs are distributed in rows, the number of barb rows is 2 rows, and two adjacent rows are inverted The angles between spines are equal;

[0047] (1.3) Cut...

Embodiment 3

[0055] A preparation method of a suture-free three-dimensional textile-based conductive myocardial patch, specifically as follows:

[0056] (1) prepare barbed short wire;

[0057] After the molten polypropylene solution is poured into the barbed stub mold, it is solidified and formed. Among them, the length of the short line is 3 mm, and the diameter is 35 μm; one end of the short line is a beveled needle-point shape, and the other end is a plane; the angle between the beveled needle-pointed slope and the short line is 10°; The thorns are located on the peripheral surface of the short line; the distance between adjacent barbs on the short line of the barb is 0.3mm, and the angle between the barb and the short line (trunk axis) is 10°; all the barbs are facing the end where the plane of the short line is located; Along the axial direction of the short line, barbs are distributed in rows, the number of barb rows is 3 rows, and the angle between two adjacent rows of barbs is equ...

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Abstract

The invention relates to a suture-free three-dimensional textile-based conductive myocardial patch and a preparation method thereof. The preparation method comprises the following steps of: vertically placing a plurality of barb short lines on one side of the textile-based conductive myocardial patch, wherein one end of each barb short line is in contact with the surface of the textile-based conductive myocardial patch; fixing the barb short lines on one side of the textile-based conductive myocardial patch by adopting a hot melting process; and enabling the axial direction of the barb short lines of the prepared three-dimensional textile-based conductive myocardial patch to be perpendicular to the plane of the textile-based conductive myocardial patch, wherein the plurality of barb short lines are uniformly distributed on the same side of the textile-based conductive myocardial patch, the barb short lines are short lines with barbs, and the barbs are positioned on the peripheral surfaces of the short lines and are uniformly arranged along a single direction. Compared with a traditional myocardial patch, the myocardial patch disclosed by the invention has the advantages that the suture process in the implanting process of the myocardial patch is avoided, myocardial repair can be realized through a thoracoscopic surgery, the surgical difficulty and time are reduced, postoperative complications are reduced, and the myocardial patch has excellent clinical application prospects and market prospects.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a suture-free three-dimensional textile-based conductive myocardial patch and a preparation method thereof. Background technique [0002] Myocardial infarction (MI) and its complications are one of the leading causes of death in the world. In China, more than 1 million people die of myocardial infarction every year, and the incidence rate is increasing year by year. Although the widespread application of interventional therapy and new thrombolytic reperfusion therapy has significantly reduced the mortality rate of MI patients in the acute phase, the mortality rate of post-MI complications remains high. The main reason is that the myocardial tissue necrosis in the infarction area is gradually replaced by fibrotic scar tissue, and the latter's contractility and electrical conductivity are far weaker than normal myocardial tissue, which leads to the weakening of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/00
CPCA61F2/0063
Inventor 毛吉富李沂蒙魏乐倩单梦琪卢莎岳斌王富军王璐
Owner DONGHUA UNIV
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