Biomarkers for diagnosing endometrial cancer as well as product and application thereof

Abstract

The invention discloses biomarkers for diagnosing endometrial cancer as well as a product and application thereof, and provides application of reagents for detecting biomarkers TMSB10, EIF3E and PDIA6 in a sample to be detected in preparation of the product for diagnosing and/or assisting in diagnosing endometrial cancer. Verification results show that the combination of TMSB10, EIF3E and PDIA6 has relatively good diagnosis efficiency, whether a subject suffers from the endometrial cancer or the risk of suffering from the endometrial cancer or not can be diagnosed in an early stage according to the combination of TMSB10, EIF3E and PDIA6, and good clinical application value is achieved.

Description

technical field [0001] The invention belongs to the fields of biology and medicine, in particular, relates to a biomarker for diagnosing endometrial cancer, more specifically, relates to a biomarker for diagnosing endometrial cancer, and its product and application. Background technique [0002] Endometrial cancer (Uterine corpus endometrial carcinoma, UCEC) is an epithelial tumor on the endometrium derived from the abnormal proliferation of endometrial cells, and is also a malignant tumor of the female reproductive system with a high incidence rate. Worldwide, about 50,000 women die from UCEC every year (Onstad MA, Schmandt RE, Lu KH. Addressing the role of obesity in endometrial cancer risk, prevention, and treatment. J Clin Oncol , 2016, 34(35):4225-4230). UCEC accounts for about 20%-30% of female reproductive system tumors, and its incidence is second only to cervical cancer (Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017[J]. CA Cancer J Clin, 2017, 67(1): 7-30...

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Problems solved by technology

[0003] Studies have shown that protein arginine methyltransferase 6 (PRMT6) can promote the occurrence and development of UCEC (Jiang N, Li QL, Pan W, et al. PRMT6 promotes endometrial cancer via AKT / mTOR signaling and indicates poor prognosis.Int J Biochem Cell Biol,2020,120:105681); LINC01123 upregulation is significantly correlated with clinical progression and poor prognosis of UCEC patients (Yang Y, Wu J, Zhou H, et al.STAT1-induced upregulation of lncRNA LINC01123 predictspoor prognosis and promotes the progression of endometrial cancer through miR-516b / KIF4A.Cell Cycle, 2020,19(12):1502-1516), but so far, the molecular mechanism of UCEC development is still not completely clear, further causing the An effective method for early diagnosis of endometrial cancer. The current diagnosis of endometrial cancer is mainly based on the subject's medical history, clinical examination, pathological examination and various auxiliary examination results to determine the diagnosis and clinical stage. The main detection methods include: B Ultra-examination, diagnostic curettage, hysteroscopy and lymphography, these methods have the disadvantages of low detection rate and easy to cause serious physical pain to patients.

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