Method for designing instrument for screening and detecting 2019 novel coronavirus pneumonia

A coronavirus and pneumonia technology, applied in the field of instrument design for evaluating the new coronavirus pneumonia, can solve the problem of no non-invasive evaluation of the efficacy of the new coronavirus pneumonia, such as instruments or technologies, and achieve the effect of simple operation

Inactive Publication Date: 2021-08-17
SHANGHAI JIAO TONG UNIV
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  • Description
  • Claims
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Problems solved by technology

So far there is no instrument or technology for non-invasive

Method used

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  • Method for designing instrument for screening and detecting 2019 novel coronavirus pneumonia
  • Method for designing instrument for screening and detecting 2019 novel coronavirus pneumonia
  • Method for designing instrument for screening and detecting 2019 novel coronavirus pneumonia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Autofluorescence imaging detection with an excitation light wavelength of 460-500nm in the range of 500-580nm emitted by the arms, palms, fingers and nails of the 2019 novel coronavirus pneumonia population and healthy population. The experimental results show that compared with the autofluorescence intensity of each body surface position of healthy people, the autofluorescence intensity of the corresponding position of the 2019-nCoV patients is significantly higher, and the higher the fluorescence intensity, the more severe the 2019-nCoV pneumonia ( figure 1 with figure 2 ).

Embodiment 2

[0034] Autofluorescence imaging detection with an excitation light wavelength of 460-500nm in the range of 500-580nm emitted by the arms, palms, fingers and nails of the 2019 novel coronavirus pneumonia population and healthy population.

[0035] Analyze and quantify the collected fluorescence intensity. For a single location, if the subject's autofluorescence intensity at that location was 1.5 times higher than the average value of the healthy population in the database for that location, the location was considered to have high fluorescence intensity. It was found that the number of hyperfluorescent sites in the 2019 novel coronavirus pneumonia population was significantly higher than that in the healthy population ( image 3 ).

[0036] The inventor also used the autofluorescence intensity of a single location on the body surface to screen and detect the 2019 novel coronavirus pneumonia, and found that the false positive rate and false negative rate were significantly high...

Embodiment 3

[0038] Autofluorescence imaging detection with an excitation light wavelength of 460-500nm in the range of 500-580nm emitted by the arms, palms, fingers and nails of the 2019 novel coronavirus pneumonia population and healthy population. The collected fluorescence intensity is analyzed and quantified, and then receiver operating characteristic curve analysis (ROC curve analysis) is performed. Accompanying drawing is the nail autofluorescence analysis result ( Figure 4 ) and palm autofluorescence analysis results ( Figure 5 ).

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Abstract

The invention provides a method for designing an instrument for screening and detecting 2019 novel coronavirus pneumonia, and provides a method for designing the instrument for detecting autofluorescence intensity of human skin and fingernails, wherein the method comprises the steps: irradiating a plurality of positions of the skin and fingernails of a detected person by adopting exciting light, wherein the positions comprise but not limited to inner sides of left and right index fingers, left and right palm centers, inner sides of left and right elbows and left and right fingernails; stimulating autofluorescence of the skin and fingernails; acquiring autofluorescence signals of the skin and fingernails of the detected person; analyzing the intensity of the obtained autofluorescence signals; after the data is acquired, evaluating the autofluorescence intensity of each detection position manually or by adopting equipment; and comparing the autofluorescence intensity with the autofluorescence intensity of the corresponding position of a healthy person, and if the more, the detected person has a significant rise in the positions, or the higher the intensity of the rise, compared with healthy person, the higher possibility, the device can display that the detected person is suffer from 2019 novel coronavirus pneumonia; the device has the advantages of being easy to operate, noninvasive, economical, portable and the like.

Description

technical field [0001] The invention belongs to the technical field of instrument design for evaluating novel coronavirus pneumonia, and in particular relates to a method and principle of instrument design for screening and detecting 2019 novel coronavirus pneumonia. Background technique [0002] Coronaviruses are a large family of viruses known to cause colds as well as more serious illnesses such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). The novel coronavirus is a new strain of coronavirus that has never been found in humans before. Multiple cases of viral pneumonia were found, all diagnosed as viral pneumonia / lung infection. Common signs after a person is infected with a coronavirus include respiratory symptoms, fever, cough, shortness of breath, and dyspnea. In more severe cases, infection can lead to pneumonia, severe acute respiratory syndrome, kidney failure, and even death. [0003] So far there is no instrument or te...

Claims

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Application Information

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IPC IPC(8): G01N21/64G01N21/01
CPCG01N21/6402G01N21/01
Inventor 殷卫海张铭超陶钺
Owner SHANGHAI JIAO TONG UNIV
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