Drug Solubilization System and Its Application in Pesticide Preparation
A technology for pesticide preparations and medicines, which is applied to a medicine solubilization system and its application field in pesticide preparations, can solve the problems of unstable dispersed aqueous solution and insoluble medicines in water, etc.
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Embodiment 1
[0015] Select the poloxamer high molecular polymer, and stir the poloxamer and hydroxymethylated rosin in an oil bath at 80°C for 1.5 hours by hot-melt method to obtain a uniform and stable hot-melt product, and then add pyrimidine Strobestrobin and Kungfu-thrin, continue magnetic stirring for 30 minutes to obtain a homogeneous system, cool to obtain a drug-loaded solid dispersion. The experimental components are shown in Table 1.
[0016] Table 1
[0017]
Embodiment 2
[0019] Select PEG 6000 high molecular polymer, and PEG 6000 and hydroxymethylated rosin were stirred magnetically for 1.5 hours in an oil bath at 80°C by hot-melt method to obtain a uniform and stable hot-melt product, and then added azoxystrobin, kung fu Pyrethrin, continue magnetic stirring for 30 minutes to obtain a homogeneous system, cool to obtain a drug-loaded solid dispersion, the experimental components are shown in Table 2.
[0020] Table 2
[0021]
[0022] Put 1 g of the obtained solid dispersion into a beaker, add 250 ml of hard water, and stir on a 100 r / min magnetic stirrer at 25° C. Record the complete disintegration time of the drug solid in the beaker. Dilute the above-mentioned completely disintegrated drug solution by 100 times, take the supernatant after standing still, inject the sample through a 0.45 μm microporous membrane, measure the peak area by HPLC, and calculate the dissolved amount of the drug in water according to the standard curve.
Embodiment 3
[0024] Select PVP K30 high molecular polymer, dissolve PVP K30 and hydroxymethylated rosin with methanol through solvent evaporation method, then add azoxystrobin and kaufthrin, stir magnetically for 30 minutes, and obtain a homogeneous system after the solvent is evaporated, cool, The drug-loaded solid dispersion was obtained, and the experimental components are shown in Table 3.
[0025] table 3
[0026]
[0027] Put 1 g of the obtained solid dispersion into a beaker, add 250 ml of hard water, and stir on a 100 r / min magnetic stirrer at 25° C. Record the complete disintegration time of the drug solid in the beaker. Dilute the above-mentioned completely disintegrated drug solution by 100 times, take the supernatant after standing still, inject the sample through a 0.45 μm microporous membrane, measure the peak area by HPLC, and calculate the dissolved amount of the drug in water according to the standard curve.
[0028] The results obtained for the above examples are sho...
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