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Capsule for treating infantile autism and preparation method thereof

A technology of autism and capsules, which is applied in the field of capsules and its preparation for the treatment of children with autism, and can solve problems affecting neurodevelopment and function, increased lymphocyte population density, and difficulty in transforming and absorbing immune abnormal nutrients, etc. Achieve the effects of inhibiting neuroendocrine stress response, improving urine metabolites, and inhibiting the production of spoilage products

Active Publication Date: 2021-08-31
广东康盾高新技术产业集团股份公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These patients may have symptoms such as esophagitis, gastritis, enterocolitis, insufficient disaccharidase activity, and increased population density of lymphocytes. About 1 / 2 of them are accompanied by diarrhea and constipation. They are also more prone to irritability, anxiety, and social withdrawal. After improving the gastrointestinal symptoms, the severity of the condition of ASD patients can be reduced. Abnormal intestinal flora can lead to immune abnormalities or difficulty in nutrient conversion and absorption, which will eventually affect neurodevelopment and function. The patent "a kind of improvement Traditional Chinese Medicine Composition for Intestinal Microenvironment of Patients with Autism Spectrum Disorders and Its Preparation Method and Application”, Patent No.: CN111789917A, using traditional Chinese medicine composition to improve the intestinal tract to treat autism, the curative effect is not obvious, therefore, it is urgent to pass Effective medicine can improve intestinal flora, promote absorption, and return to normal

Method used

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  • Capsule for treating infantile autism and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A capsule for treating children with autism: including the following raw materials in parts by weight: 33 parts of galacto-oligosaccharides, 12 parts of succinic anhydride, 20 parts of pumpkin polysaccharide, 22 parts of rutinose, 12 parts of rice fermentation filtrate, 12 parts of β-carotene 10 parts, 10 parts of strains, 10 parts of microcrystalline cellulose, and 0.1 part of hypromellose, wherein the strains are composed of Lactobacillus acidophilus, Bacteroides fragilis, and Lactobacillus casei in a weight ratio of 1:1:2 ,

Embodiment 2

[0026] A capsule for treating children with autism: including the following raw materials in parts by weight: 62 parts of galacto-oligosaccharides, 28 parts of succinic anhydride, 33 parts of pumpkin polysaccharide, 40 parts of rutinose, 33 parts of rice fermentation filtrate, 25 parts of β-carotene part, 19 parts of strains, 20 parts of starch, and 3 parts of povidone; the strains are composed of Lactobacillus acidophilus, Bacteroides fragilis, and Lactobacillus casei in a weight ratio of 1:3:6;

Embodiment 3

[0028] A capsule for treating children with autism: comprising the following raw materials in parts by weight: 33-62 parts of galacto-oligosaccharides, 20 parts of succinic anhydride, 26 parts of pumpkin polysaccharide, 31 parts of rutinose, 25 parts of rice fermentation filtrate, β-carrot 20 parts of prime, 15 parts of strains, 15 parts of sodium carboxymethyl starch, and 1.3 parts of sodium alginate; composition;

[0029] The capsule of above-mentioned embodiment 1~3 adopts following preparation method:

[0030] S1. Mix and stir the above polygalactose, succinic anhydride, pumpkin polysaccharide, rutin, rice fermentation filtrate, and β-carotene to obtain the mixed material I;

[0031] S2. Add the strains to the mixed material I obtained in S1, stir and let it stand for 12-33 hours to obtain the mixed material II;

[0032] S3. Mix the mixed material II obtained in S2 with the filler, and add a binder solution with a mass concentration of 0.2-3% to make a soft material;

...

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Abstract

The invention provides a capsule for treating infantile autism and a preparation method thereof. The capsule is prepared from the following raw materials in parts by weight: 33 to 62 parts of galactooligosaccharide, 12 to 28 parts of succinic anhydride, 20 to 33 parts of pumpkin polysaccharide, 22 to 40 parts of rutinose, 12 to 33 parts of rice fermentation filtrate, 12 to 25 parts of beta-carotene, 10 to 19 parts of strain, 10 to 20 parts of filler and 0.1 to 3 parts of adhesive. The raw materials are reasonably selected and scientifically proportioned, and all the components interact with one another to selectively stimulate the composition and activity of specific intestinal flora; and through a regulating system for regulating bidirectional signal communication between the intestinal tract and the nervous system, the composition and activity of the specific intestinal flora are selectively stimulated.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a capsule for treating children with autism and a preparation method thereof. Background technique [0002] Autism (autism or autistic disorder), also known as autism, is a diffuse central nervous system developmental disorder, clinically manifested as social impairment, narrow interests, repetitive behavior, etc.; studies have found that 9% to 91% Most ASD patients have digestive system-related symptoms, including abdominal distension, diarrhea, constipation, belching, and abnormally foul-smelling stools. These patients may have symptoms such as esophagitis, gastritis, enterocolitis, insufficient disaccharidase activity, and increased population density of lymphocytes. About 1 / 2 of them are accompanied by diarrhea and constipation. They are also more prone to irritability, anxiety, and social withdrawal. After improving the gastrointestinal symptoms, the severity of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/48A61P25/00A61K31/702A61K31/34A61K31/715A61K31/7016A61K31/015A61K35/747A61K35/741
CPCA61K31/702A61K31/34A61K31/715A61K31/7016A61K36/899A61K31/015A61K35/747A61K35/741A61K9/4866A61P25/00A61K2300/00Y02A50/30
Inventor 湛振键刘世豪孟艳芬湛楚沂
Owner 广东康盾高新技术产业集团股份公司
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