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A kind of composition and its preparation method and application

A technology of composition and preparation, which is applied in the field of composition and its preparation, can solve problems such as hindering the recovery of psychological function, cognitive dysfunction of patients, and increased risk, so as to improve cognitive function damage, improve treatment compliance, The effect of shortening the treatment cycle

Active Publication Date: 2022-05-03
北京斯利安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In recent years, cognitive dysfunction in patients with depression has attracted more and more attention from scholars at home and abroad. Studies have found that cognitive dysfunction in patients with depression may be independent of depressive symptoms, and some patients have impaired cognitive function. Improves with depressive symptoms, however, a significant proportion of patients suffer from cognitive impairment even when they are euthymic
In turn, impairment of cognitive function also hinders the recovery of psychological function, which in turn causes persistent difficulties in work, family, and social function
There are also studies that believe that after antidepressant treatment in elderly patients with cognitive impairment, some cognitive functions will be improved, but not necessarily to a normal level, especially memory and executive function, the development of elderly depression. Risk of developing progressive dementia may increase

Method used

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  • A kind of composition and its preparation method and application
  • A kind of composition and its preparation method and application
  • A kind of composition and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] 1. Research objects and inclusion criteria

[0061] Elderly depressed patients with cognitive impairment who visited the clinic from January 2019 to October 2020 were selected. Inclusion criteria: ①Meet the diagnostic criteria for depressive episodes of the International Classification of Diseases (tenthedition, ICD-10); ②Hamilton Depression Scale-24 item (HAMD-24) score >20 points; ③age 55-65 years old; ④years of education ≥ 5 years, no barriers to reading and writing in Chinese; ⑤not taking any antidepressant drugs in the past 2 weeks. Exclusion criteria: ①Severe organic diseases, such as uncontrollable hypertension; ②There are contraindications to vortioxetine treatment; ③There is a history of vortioxetine treatment within the past 6 months; ⑤Blood routine, biochemical , Abdominal color Doppler ultrasound and electrocardiogram have abnormal clinical significance indicators.

[0062] A total of 90 patients who met the inclusion criteria but did not meet the exclusio...

Embodiment 2

[0094] 1. Experimental animals and grouping

[0095] Healthy aged male SD rats (Latin scientific name: Sprague-Dawley) that passed the quarantine were taken, aged 14-18 months, and fed with normal diet for one week, and randomly divided into sham-operated control group, model control group, and vortioxetine group. , Calcium 5-methyltetrahydrofolate + betaine group, vortioxetine + calcium 5-methyltetrahydrofolate + betaine high and low dose groups, 10 rats in each group.

[0096] 2. Preparation of animal models

[0097] Experimental rats were fasted for 8-12 hours before operation, free to drink water, anesthetized by intraperitoneal injection of 10% chloral hydrate (3ml / kg), routine skin preparation and disinfection in the middle of the neck, incision 2-3cm, blunt separation of both sides Common carotid artery, about 1.5cm away from the bifurcation of internal carotid artery and external carotid artery on the proximal side of common carotid artery Severe stenosis), the commo...

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Abstract

The application discloses a composition comprising: 5-methyltetrahydrofolate and \or its pharmaceutically acceptable salt; betaine and \or its pharmaceutically acceptable salt; and vortixi Ting and \or its pharmaceutically acceptable salt. The composition is used for the treatment of cognitive impairment of senile depression, and compared with vortioxetine alone and 5-methyltetrahydrofolate and betaine combination, it can synergize and complement each other, shorten the treatment cycle, improve Clinical safety and treatment compliance, easy to promote and apply.

Description

technical field [0001] The invention relates to a composition, a preparation method and application thereof, and belongs to the field of medicine. Background technique [0002] Depression is a common severe mental illness with diverse clinical manifestations, including affective symptoms, physical symptoms, and cognitive symptoms. Among them, cognition is a new clinical focus of depression, and more and more evidences show that patients with depression have cognitive impairment, such as attention, learning and memory, and executive dysfunction. [0003] With the advent of the era of global population aging, senile depression has become one of the mental diseases that threaten the mental health of the elderly. Elderly depression mainly refers to patients with depression over the age of 60. Studies have shown that as many as 23.6% of the elderly in China have depressive symptoms, and the incidence is increasing year by year. Elderly patients with depression have the characte...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/519A61P25/24A61P25/28A61K31/205A61K31/495
CPCA61K31/519A61K31/205A61K31/495A61P25/28A61P25/24A61K2300/00
Inventor 耿媛媛杨卓理易斌
Owner 北京斯利安药业有限公司
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