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Method for determining content of peimine and peiminine in Huangshi Xiangsheng buccal tablet

A technology of peiminin B and peiminin A, which is applied in the field of detection of active ingredients of drugs, can solve the problems of lack of methods for determining the content of peiminin A and peiminin B in Huangshi Xiangsheng buccal tablets, and achieve a reduction in sample size. Extraction time, reduce analysis and detection time, and improve detection efficiency

Inactive Publication Date: 2021-09-17
WUXI JIMIN KEXIN SHANHE PHARMA
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Problems solved by technology

[0009] The prior art lacks the method for determining the content of peiminin A and peiminin B in Huangshi Xiangsheng buccal tablets

Method used

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  • Method for determining content of peimine and peiminine in Huangshi Xiangsheng buccal tablet
  • Method for determining content of peimine and peiminine in Huangshi Xiangsheng buccal tablet
  • Method for determining content of peimine and peiminine in Huangshi Xiangsheng buccal tablet

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Experimental program
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Effect test

Embodiment 1

[0053] Determination of Peiminin A and Peiminin B in Huangshi Xiangsheng Buccal Tablets

[0054] 1) Reference substance solution: take peiminin A reference substance and peiminin B reference substance, accurately weighed, add methanol to make a mixed solution containing 0.25 mg of peiminin A and 0.15 mg of peiminin B in every 1 ml, namely have to;

[0055] 2) The test solution: take 8g of Huangshi Xiangsheng buccal tablets, weigh them accurately, add 10ml of concentrated ammonia test solution-ethanol (1:2) mixed solution dropwise to make it moist, seal it tightly, leave it for 20min, add ether: chloroform : Ethanol (50:16:5) mixed solution 25ml, ultrasonic treatment (power 250W, frequency 50Hz, water bath temperature below 30°C) for 30min, filter, filter residue with ether: chloroform: ethanol (50:16:5) Wash the mixed solution in an appropriate amount, combine the filtrate and lotion, evaporate to dryness on a water bath at 60°C, dissolve the residue with methanol and transfe...

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Abstract

The invention relates to a method for determining the content of peimine and peiminine in Huangshi Xiangsheng buccal tablets, which comprises the following steps: 1) preparing a reference substance solution: taking a peimine reference substance and a peiminine reference substance, precisely weighing, and adding methanol to prepare a mixed solution; 2) preparing a test solution: adding a concentrated ammonia test solution-ethanol (1:2) mixed solution into the Huangshi Xiangsheng buccal tablet, adding a mixed solution of diethyl ether, trichloromethane and ethanol (50:16:5) for dissolving, filtering, washing filter residues by using the mixed solution of diethyl ether, trichloromethane and ethanol (50:16:5), combining filtrate and washing liquor, volatilizing to dryness, dissolving residues by using methanol, and filtering to obtain the test solution; and 3) determining: precisely sucking the reference substance solution and the test solution, injecting into a high performance liquid chromatograph to obtain a chromatogram, and respectively calculating the contents of peimine and peiminine by using an external standard two-point method logarithmic equation according to the peak area of the chromatogram.

Description

technical field [0001] The invention relates to a method for detecting active ingredients of medicines, in particular to a method for determining the contents of peiminin A and peiminin B in Huangshi Xiangsheng buccal tablets. Background technique [0002] Huang's sound buccal tablet is a compound preparation, which is composed of mint, fritillaria, sterculia, cicada slough, rhubarb, forsythia, bellflower, catechu, chebula meat, chuanxiong, licorice, menthol and other medicinal materials. It has the effects of relieving throat and opening sound, clearing away heat and resolving phlegm, reducing swelling and relieving pain. It is used for the dark throat caused by wind-heat invading the lung and excessive lung-heat. Symptoms are: hoarseness, pain in vocalization, dry throat; acute laryngitis and acute attack of chronic laryngitis see the above syndromes. [0003] In the prescription, Fritillaria Fritillaria is the king drug, which can detoxify, dissipate stagnation and elimi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/04G01N30/06G01N30/14G01N30/86G01N30/74G01N30/60
CPCG01N30/02G01N30/04G01N30/06G01N30/14G01N30/8634G01N30/74G01N30/6052G01N2030/047
Inventor 张小娜戴亚妮叶馨薇邱婷
Owner WUXI JIMIN KEXIN SHANHE PHARMA
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