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Liposome wrapping active ingredients, preparation method and application thereof

A technology of active ingredients and liposomes, which is applied in the field of medicine, can solve the problems of loss of activity and instability, and achieve the effects of relatively small particle size, convenient improvement, and good light transmittance

Active Publication Date: 2021-09-24
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, retinoids are very unstable compounds, which will gradually decompose and lose their activity under high temperature and light.

Method used

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  • Liposome wrapping active ingredients, preparation method and application thereof
  • Liposome wrapping active ingredients, preparation method and application thereof
  • Liposome wrapping active ingredients, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] The preparation of embodiment 1 liposome

[0097] (1) 1% of hydrogenated lecithin, 0.2% of sodium subtilisin and 61.8% of glycerin are mixed uniformly to obtain an alcohol phase;

[0098] (2) Add 20% squalane and 2% vitamin A palmitate to the above-mentioned alcohol phase and mix, add 15% deionized water, and homogenize at a temperature of 75°C obtain a homogeneous mixture;

[0099] (3) The above-mentioned homogeneous mixture is subjected to high-pressure homogenization at a temperature of 75° C., a pressure of 800 bar and a cycle number of 3 times for homogenization to obtain vitamin-encapsulated liposomes.

Embodiment 2

[0100] The preparation of embodiment 2 liposomes

[0101] 2% hydrogenated lecithin, 0.2% subtilisin sodium and 60.8% glycerin were mixed uniformly to obtain the alcohol phase, and other preparation methods were the same as in Example 1 to obtain vitamin-encapsulated liposomes.

Embodiment 3

[0102] The preparation of embodiment 3 liposomes

[0103] 3% hydrogenated lecithin, 0.2% subtilisin sodium and 59.8% glycerin were mixed uniformly to obtain the alcohol phase, and other preparation methods were the same as in Example 1 to obtain vitamin-encapsulated liposomes.

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Abstract

The invention discloses lipidosome wrapping active ingredients, a preparation method and application of the lipidosome. The lipidosome comprises an alcohol phase, water and an active component, wherein the alcohol phase comprises hydrogenated lecithin, sodium surfactin and polyol. Active ingredients are added in the preparation process, stable and efficient wrapping of the active ingredients can be achieved, the stability of the obtained lipidosome is better, active substances can be kept to be more stable at high temperature, and better skin permeability is achieved; and water is added in the preparation process, so that the obtained lipidosome is good in dispersity in an aqueous solution, reduced in viscosity, improved in fluidity and capable of being quickly dissolved in water, the convenience of the lipidosome in use is improved, and the lipidosome is easily added into various dosage forms.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a liposome for encapsulating active ingredients, a preparation method and an application thereof. Background technique [0002] "Anti-aging" is the eternal goal that people pursue, and it is also a research hotspot for scientific researchers. Retinoids have been proven to be one of the most effective anti-aging actives in many human tests and are increasingly being used in cosmetics. However, retinoids are very unstable compounds, and high temperature and light will gradually decompose them and lose their activity. [0003] In the prior art, active substances lacking stability such as retinol are encapsulated by liposomes to improve the stability and transdermal property of unstable active ingredients. Liposome (Liposome) is a dosage form for drug delivery. It is a spherical-like artificial membrane with phospholipids as the wall material. It is self-assembled in water to form...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/55A61K8/34A61K8/68A61K8/67A61K8/35A61K8/14A61Q19/08
CPCA61K8/64A61K8/553A61K8/345A61K8/68A61K8/671A61K8/355A61K8/14A61Q19/08A61K2800/805
Inventor 陈晗俊庄洁安冬唐毓萍孙晓梅赵毅龚颖吴瑶瑶瞿怡宁吴旭段国兰
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD