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Application of chlorogenic acid in preparation of medicine for treating central nervous system tumors

A technology of central nervous system and chlorogenic acid, applied in the field of medicine, can solve the problems of multidrug resistance and overexpression of multidrug resistance genes in cells

Pending Publication Date: 2021-09-24
SICHUAN JIUZHANG BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main cause of refractory DLBCL is the overexpression of cellular multidrug resistance genes, resulting in multidrug resistance to chemotherapy drugs
There is no report on the use of chlorogenic acid to treat central nervous system tumors

Method used

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  • Application of chlorogenic acid in preparation of medicine for treating central nervous system tumors
  • Application of chlorogenic acid in preparation of medicine for treating central nervous system tumors
  • Application of chlorogenic acid in preparation of medicine for treating central nervous system tumors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 Chlorogenic acid oral preparation prescription of the present invention

[0028] 1. Prescription 1

[0029] Chlorogenic acid 1000g.

[0030] Preparation method: Weigh chlorogenic acid according to the prescription, and aseptically pack it into powder.

[0031] 2. Prescription II

[0032] Chlorogenic acid 1000g, filler 500g, binder 5g.

[0033] Preparation method: Weigh chlorogenic acid, fillers, and binders according to the prescription, granulate, granulate, and pack into granules.

[0034] 3. Prescription Three

[0035] Chlorogenic acid 1000g, filler 500g, binder 5g, lubricant 3g.

[0036] Preparation method: Weigh chlorogenic acid, filler and binder according to the prescription, granulate, granulate, add lubricant, compress into tablets to obtain tablets.

[0037] The filler is one or more of mannitol, lactose, starch, microcrystalline cellulose, and dextrin; the binder is one of sodium carboxymethyl cellulose and PVP (polyvinylpyrrolidone) or tw...

Embodiment 2

[0038] Embodiment 2 Prescription of chlorogenic acid injection preparation of the present invention

[0039] 1. Prescription 1

[0040] Chlorogenic acid 1000g.

[0041] Preparation method (1): Aseptically weigh chlorogenic acid according to the prescription, mix evenly, and aseptically pack into powder injection.

[0042] Preparation method (2): Weigh chlorogenic acid according to the prescription, dissolve it in water for injection, filter and sterilize, and freeze-dry to obtain a freeze-dried powder injection.

[0043] 2. Prescription II

[0044] Chlorogenic acid 1000g, scaffold agent 2667g, antioxidant 67g.

[0045] Preparation method: Weigh chlorogenic acid, scaffolding agent, and antioxidant according to the prescription, dissolve them in water for injection, filter and sterilize, and freeze-dry (freeze-drying conditions: pre-freezing: temperature ≤ -40°C, normal pressure, drying time 2-4h , freeze; primary drying: temperature ≤ -13°C, negative pressure, drying time ≥...

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Abstract

The invention provides application of chlorogenic acid in preparation of a medicine for treating central nervous system tumors, and belongs to the field of medicines. It is found for the first time that chlorogenic acid can effectively treat diffuse large B-cell lymphoma, a new and high-safety choice is provided for clinical treatment of central nervous system tumors, especially diffuse large B-cell lymphoma, and the chlorogenic acid has a good application prospect.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a new application of chlorogenic acid in the preparation of medicines for treating central nervous system tumors. Background technique [0002] Central nervous system lymphoma is a central nervous system tumor with a low incidence, accounting for 1% to 3% of central nervous system tumors. With the application of immunosuppressants, the incidence of the disease has been on the rise in recent years. Central nervous system lymphoma includes primary central nervous system lymphoma and secondary lymphoma in which systemic lymphoma invades the central nervous system. Primary central nervous system lymphoma, also known as primary central nervous system lymphoma (PCNSL), accounts for about 8% of central nervous system lymphoma. [0003] Primary central nervous system lymphoma is a relatively rare type of non-Hodgkin's lymphoma (non-Hodgkin's lymphoma) that originates in the central ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61P35/00
CPCA61K31/216A61K9/0053A61K9/0019A61P35/00
Inventor 张洁李文斌黄望张雅张飞徐敏
Owner SICHUAN JIUZHANG BIO TECH CO LTD
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