Method for extracting and separating effective components from liquorice

An active ingredient, licorice technology, applied in the directions of medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, organic chemistry, etc., can solve the problems of complicated operation, environmental pollution, pollution of the environment, etc. The effect of consumption and saving of licorice resources and high comprehensive utilization rate

Pending Publication Date: 2021-09-24
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many steps in the repeated crystallization method, and the acid-base reagents used cause environmental pollution; the solvent separation method can realize large-scale production, but consumes solvents and energy, the operation is cumbersome, and pollutes the environment; the two-phase extraction method is easy to pollute the environment, and the production The efficiency is not high; the membrane separation method makes the production process simple, but the production cost is high, while the macroporous resin adsorption method has a better separation effect, and the production cost can be reduced after the alcohol recovery is controlled, and there is basically no environmental pollution

Method used

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  • Method for extracting and separating effective components from liquorice
  • Method for extracting and separating effective components from liquorice
  • Method for extracting and separating effective components from liquorice

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035]Weigh 50kg of dried licorice rhizomes, carry out net selection, elutriation, cutting, drying and crushing, pass through a 30-40 mesh screen, pass through a quantitative feeder, and transport them to the feeding device of the ultrasonic continuous countercurrent equipment. Feeding at high speed, the extraction solvent is added according to the mass volume ratio of licorice and extraction solvent 1:10, the total volume of the solvent is 500L, and the extraction solvent is selected from different proportions of ethanol: water mixed solvent, specifically pure water, 30% ethanol, 60% ethanol , the solvent of each gradient accounts for 1 / 3 of the total volume of the extraction liquid, and the liquid is evenly drained, the flow rate of the solvent is controlled, and the liquid level in the extraction tube is kept balanced. Continuous countercurrent ultrasonic extraction for 90min.

[0036] The medicinal dregs are extruded and recovered, steam evaporated and recovered, and conve...

Embodiment 2

[0039] Weigh 100kg of dried licorice rhizomes, carry out net selection, elutriation, cutting, drying, and crushing, then pass through a 30-40 mesh screen, pass through a quantitative feeder, and transport them to the feeding device of the ultrasonic continuous countercurrent equipment. Feeding at high speed, the extraction solvent is added according to the mass volume ratio of licorice and extraction solvent 1:10, the total volume of the solvent is 1000L, and the extraction solvent is selected from different proportions of ethanol: water mixed solvent, specifically pure water, 30% ethanol, 60% ethanol , the solvent of each gradient accounts for 1 / 3 of the total volume of the extraction liquid, drain the liquid evenly, control the flow rate of the solvent to keep the liquid level in the leaching chamber balanced, set the extraction temperature to 55°C, and the ultrasonic power to 1000W, under normal pressure Continuous countercurrent ultrasonic extraction was carried out for 150...

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Abstract

The invention discloses a method for extracting and separating glycyrrhizic acid, glycyrrhizic flavone and glycyrrhiza polysaccharide from liquorice. The method comprises the following steps of cleaning the liquorice, crushing, conveying the liquorice into a feeding device of ultrasonic continuous countercurrent equipment through a quantitative feeder, extracting by adopting a gradient solvent at the extraction temperature of 50-60 DEG C, wherein the ratio of the total volume of the extraction solvent to the weight of the liquorice is (8-10): 1, and the total extraction time is 90-150 minutes; and concentrating under reduced pressure until the volume is 1/15-1/20 of the original volume, performing spray drying, purifying a crude product through macroporous adsorption resin, and drying to obtain glycyrrhiza polysaccharide, glycyrrhizic acid and glycyrrhizic flavone compounds. The extraction rate of effective components in liquorice is high, can reach 90% and is higher than the extraction rate of a common extraction process; and the comprehensive utilization rate of liquorice is high, liquorice resources are saved, environmental pollution is reduced, and the method can be widely applied to extraction and purification of effective components of medicinal materials.

Description

technical field [0001] The invention belongs to the field of chemical industry, and particularly relates to a method for gradiently extracting glycyrrhizic acid, licorice flavonoids, licorice polysaccharides and other main components in licorice by using ultrasonic continuous countercurrent equipment. Background technique [0002] Licorice is one of the traditional Chinese herbal medicines commonly used in my country. It is a perennial herb of the leguminosae genus GlycyrrhizaLinn and has extremely wide clinical application value. Chinese medicine prescriptions are inseparable from licorice, which is known as "ten directions and nine herbs". Since ancient times, it has been widely used in medicine and has the title of "old country". Licorice was first recorded in "Shen Nong's Materia Medica" and listed as top grade. It has the functions of nourishing qi and invigorating the middle, eliminating phlegm and relieving cough, relieving spasm and relieving pain, relieving medicine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484C07J63/00C08B37/00A61K125/00
CPCA61K36/484C07J63/008C08B37/0003A61K2236/333A61K2236/51
Inventor 徐希明王启龙余江南
Owner JIANGSU UNIV
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