Application of Sanhuang hypoglycemic tablets in preparation of medicine for treating type-2 diabetes osteoporosis

Abstract

The invention relates to the field of traditional Chinese medicine, in particular to application of Sanhuang hypoglycemic tablets in preparation of medicine for treating type-2 diabetes osteoporosis. The Sanhuang hypoglycemic tablets are prepared from radix astragali, radix rehmanniae, radix et rhizoma rhei, rhizoma dioscoreae, radix puerariae and radix glycyrrhizae. According to the application of the Sanhuang hypoglycemic tablets in preparation of the medicine for treating type-2 diabetes osteoporosis, on the basis of the remarkable curative effect of the Sanhuang hypoglycemic tablets in clinical treatment of type-2 diabetes, the curative effect of the Sanhuang hypoglycemic tablets on type-2 diabetic complications is further explored, during which it is found that the Sanhuang hypoglycemic tablets can have a remarkable curative effect on secondary osteoporosis caused by type-2 diabetes; and verification is carried out through animal experiments. Compared with current medicine for clinically treating type-2 diabetes osteoporosis, the Sanhuang hypoglycemic tablets have the effects of less medicine taking, few contraindications, small side effects and remarkable curative effect.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to the application of Sanhuang Jiangtang Tablets in the preparation of medicaments for treating type 2 diabetes mellitus osteoporosis. Background technique [0002] Diabetes is a common chronic metabolic disease of aging that affects most of the world's population. With the improvement of people's living standards and the extension of life expectancy, the incidence of diabetes is rising rapidly all over the world, especially in China. Type 2 diabetes (type 2diabetes mellitus, T2DM) accounts for more than 90% of the total number of diabetic patients. At present, a large number of basic and clinical studies have shown that long-term hyperglycemia can cause bone metabolism disorders, and the risk of fractures in T2DM patients can be 1-3 times that of normal people, and is accompanied by osteoporosis (OP), including bone mass Low bone strength, decreased bone strength, and...

AI Technical Summary

Problems solved by technology

[0004] Disadvantages and deficiencies in the prior art: 1. Multiple drugs are used at the same time, and long-term use causes great damage to the liver and gastrointestinal tract: The treatment of T2DOP is mainly based on hypoglycemic drugs combined with anti-osteoporosis drugs, usually two or even three drug combination

2. The curative effect is not significant, the treatment methods are relatively limited, the monotherapy is less, and the clinical flexibility is poor

3. Long-term use, expensive

4. Metformin commonly used in clinical treatment has many contraindications for the treatment of T2DOP: (1) patients who are allergic to metformin; (2) patients who are intolerant to metformin, the main adverse reaction of metformin is gastrointestinal side effects; (3) ) patients with hepatic insufficiency; (4) patients with severe renal insufficiency

[0005] To sum up, the current T2DOP treatment method is single, and there are few single-drug treatments for T2DOP with obvious disadvantages. Therefore, exploring new targeted therapy drugs for T2DOP may provide an opportunity to break through the bottleneck of current clinical treatment.

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