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Hesperetin-containing composition and application of hesperetin-containing composition in synergistic blood sugar reduction

A technology for hesperetin and a composition is applied in the field of compositions containing hesperetin, which can solve the problems of limited hypoglycemic effect of a single active ingredient and easy generation of drug resistance, so as to reduce the occurrence of drug resistance and inhibit synergistic growth. effect, dose reduction effect

Active Publication Date: 2021-09-28
ZHENGZHOU FRUIT RES INST CHINESE ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a hesperetin-containing composition and its synergistic blood sugar-lowering application, so as to solve the problems in the prior art that the single active ingredient has limited blood-sugar-lowering effect and is prone to drug resistance

Method used

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  • Hesperetin-containing composition and application of hesperetin-containing composition in synergistic blood sugar reduction
  • Hesperetin-containing composition and application of hesperetin-containing composition in synergistic blood sugar reduction
  • Hesperetin-containing composition and application of hesperetin-containing composition in synergistic blood sugar reduction

Examples

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Embodiment 1

[0046] A composition of hesperetin and galangin, wherein the mass ratio of hesperetin and galangin is 30:100; specifically, the concentrations of hesperetin and galangin in the composition are 30 μg / mL and 100 μg / mL respectively mL.

Embodiment 2

[0048] A composition of hesperetin and galangin, wherein the mass ratio of hesperetin and galangin is 30:150; specifically, the concentrations of hesperetin and galangin in the composition are 30 μg / mL and 150 μg / mL respectively mL.

Embodiment 3

[0050] A composition of hesperetin and galangin, wherein the mass ratio of hesperetin and galangin is 50:100; specifically, the concentrations of hesperetin and galangin in the composition are 50 μg / mL and 100 μg / mL respectively mL.

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Abstract

The invention discloses a hesperetin-containing composition and application of the hesperetin-containing composition in synergistic blood sugar reduction and belongs to the technical field of natural active compounds. The composition disclosed by the invention comprises hesperetin and a compound X, wherein the compound X is galangin or formononetin; wherein the mass ratio of the hesperetin to the galangin is 30: 100; and the mass ratio of the hesperetin to the formononetin is 30: 20. The composition disclosed by the invention has an obvious synergistic effect of inhibiting alpha-glucosidase, the effect of the composition is superior to that of single use of a flavone compound, the dosage of medicines can be reduced, and the occurrence of drug resistance is reduced.

Description

technical field [0001] The invention belongs to the technical field of natural active compounds, and in particular relates to a hesperetin-containing composition and its synergistic blood sugar-lowering application. Background technique [0002] Diabetes is a global chronic disease characterized by persistent high blood sugar, including type I, type II diabetes, gestational diabetes and other special types of diabetes. Type II diabetes is also called non-insulin-dependent diabetes, accounting for 95% of diabetics above. α-glucosidase is a carbohydrate hydrolase that catalyzes the release of α-glucose from the non-reducing end of the substrate. α-glucosidase exists in most microorganisms, plants and animals, and is an indispensable enzyme in the pathway of starch metabolism to generate glucose. When the activity of α-glucosidase in the human body is too high, it will cause the blood sugar in the body to be too high, thereby causing diabetes. At present, the commonly used d...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P3/10
CPCA61K31/352A61P3/10A61K2300/00A61K31/353A61K31/7048
Inventor 张强焦中高陈大磊刘杰超杨文博张春岭刘慧吕真真潘俊坤
Owner ZHENGZHOU FRUIT RES INST CHINESE ACADEMY OF AGRI SCI