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Application of manganous-manganic oxide quantum dots in preparation of anti-inflammatory drugs

A technology of manganese tetroxide quantum and manganese oxide quantum, applied in manganese oxide/manganese hydroxide, anti-inflammatory agent, drug combination, etc., can solve the problem of reduced blinking times, insufficient air humidity, abnormal tear quality and kinetics, etc. problem, to achieve the effect of reducing the level of pro-inflammatory factors, uniform size, and increasing the level of anti-inflammatory factors

Pending Publication Date: 2021-10-01
SHANGHAI JIESHI MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Excessive use of electronic products can cause dry eye disease from four aspects: 1) Staring at the screen for a long time will lead to less blinking and rapid evaporation of tears. In addition, the indoor air is not circulated, and the air humidity is not enough to make tears evaporate faster; 2) and Compared with reading when looking down, when looking forward and upward at the screen, the increase in the exposure area of ​​the tear film between the palpebral fissures will aggravate dry eye symptoms; Membrane stability decreases, and the eyes are hypoxic; 4) Eyes looking at near objects for too long will cause ciliary muscle spasm, eye adjustment power will decrease, fatigue and discomfort and blurred vision will occur

Method used

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  • Application of manganous-manganic oxide quantum dots in preparation of anti-inflammatory drugs
  • Application of manganous-manganic oxide quantum dots in preparation of anti-inflammatory drugs
  • Application of manganous-manganic oxide quantum dots in preparation of anti-inflammatory drugs

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Effect test

Embodiment 1

[0037] This embodiment provides a trimanganese tetraoxide quantum dot, which is prepared by the following preparation method:

[0038] 2.45g of Mn(OAc) 2 4H 2 The powder of O was dissolved in 70mL of DMF and stirred until fully dissolved; the above mixture was transferred to a stainless steel autoclave at 130°C for 8h; finally, centrifuged at 15000rpm for 10min and dried at 80°C for 6h to obtain a solid sample of manganese tetraoxide .

[0039] in, figure 1 For the transmission electron microscope figure of the trimanganese tetraoxide quantum dot that embodiment 1 prepares, as figure 1 As shown, the particle diameter of the trimanganese tetraoxide quantum dot is 5nm; and as figure 1 As mentioned above, the nanoparticles have a uniform size, which is conducive to large-scale production and application.

Embodiment 2

[0041] This embodiment provides a trimanganese tetraoxide quantum dot, which is prepared by the following preparation method:

[0042] 2g of Mn(OAc) 2 4H 2 The powder of O was dissolved in 60mL of DMF and stirred until fully dissolved; the above mixture was transferred to a stainless steel autoclave and kept at 130°C for 8h; finally, centrifuged at 15000rpm for 10min and dried at 80°C for 2h to obtain a solid sample of manganese tetraoxide .

Embodiment 3

[0044] This embodiment provides a trimanganese tetraoxide quantum dot, which is prepared by the following preparation method:

[0045] 3g of Mn(OAc) 2 4H 2 The powder of O was dissolved in 80mL of DMF and stirred until fully dissolved; the above mixture was transferred to a stainless steel autoclave at 130°C for 8h; finally, centrifuged at 15000rpm for 10min and dried at 80°C for 2h to obtain a solid sample of manganese tetraoxide .

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Abstract

The invention provides an application of manganous-manganic oxide quantum dots in preparation of anti-inflammatory drugs. The manganous-manganic oxide quantum dots can achieve the anti-inflammatory purpose by improving the anti-inflammatory factor level and reducing the proinflammatory factor level; therefore, the manganous-manganic oxide quantum dots can be used for preparing anti-inflammatory drugs, especially drugs for treating xerophthalmia; and the manganous-manganic oxide quantum dots have uniform size, and are beneficial to large-scale production and application.

Description

technical field [0001] The invention relates to the technical field of quantum dot synthesis, in particular to the application of a trimanganese tetraoxide quantum dot in the preparation of anti-inflammatory drugs. Background technique [0002] Dry eye is a clinically common eye disease, also known as keratoconjunctival sicca. Dry eye disease is one of the most common diseases in the elderly, and the common cause is meibomian gland dysfunction. The meibomian glands are oil-secreting glands inside the upper and lower eyelids. They open at the root of the eyelashes on the edge of the eyelids. The oil they secrete is the protective film of tears and can protect tears. As we grow older, the function of these glands gradually declines, and oil may accumulate in the canal, and tears will not be stably protected and evaporated, which will cause dry eye disease. [0003] In addition to the impact of age, people who use electronic products for too long will also greatly increase th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/32A61P29/00A61P27/02C01G45/02B82Y40/00B82Y5/00
CPCA61K33/32A61P29/00A61P27/02C01G45/02B82Y40/00B82Y5/00C01P2004/64C01P2004/04
Inventor 陈宇晖赵洪兵刘晓旭施露
Owner SHANGHAI JIESHI MEDICAL TECH
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