Enteral nutrition composition as well as preparation method and application thereof

A technology of enteral nutrition and composition, which is applied in the field of pharmaceutical preparations, and can solve problems such as the amount of vitamins and/or minerals not meeting the specified requirements, difficulties in transportation and storage, precipitation, etc.

Pending Publication Date: 2021-10-08
范师振
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AI-Extracted Technical Summary

Problems solved by technology

[0004] Enteral nutrition preparations in the prior art, including enteral nutrition suspension or liquid formula, usually have the following technical problems: (1) the product is difficult to withstand high temperature sterilization, so it is difficult to reach the standard of complete sterility; (2) In order to maintain the stability of main componen...
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Method used

[0046] Preparation: take by weighing each raw material powder (wherein magnesium chloride is magnesium chloride hexahydrate), mix, and obtain the enteral nutrition composition of 1 preparation unit. Just before u...
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Abstract

The invention provides an enteral nutrition composition. According to the composition, maltodextrin is taken as carbohydrate, calcium caseinate is taken as protein and dipotassium phosphate is taken as a potassium source, so that a prepared enteral nutrition preparation product, such as an enteral nutrition suspension, has good energy density and osmotic pressure, is resistant to high-temperature hot-pressing treatment, is free of flocculation, precipitation and other phenomena, is good in stability, is easy to form a suspension after being added with water, can tolerate heat treatment such as boiling, meets the requirement that an enteral nutrition agent is prepared immediately when being used, reduces the product transportation and storage cost, and achieves an unexpected technical effect.

Application Domain

Vitamin food ingredientsFood ingredient functions

Technology Topic

NutritionCalcium caseinate +12

Image

  • Enteral nutrition composition as well as preparation method and application thereof
  • Enteral nutrition composition as well as preparation method and application thereof
  • Enteral nutrition composition as well as preparation method and application thereof

Examples

  • Experimental program(3)
  • Effect test(12)

Example Embodiment

[0037] Example 1: Enteral nutritional composition
[0038] The product composition is shown in Table 1.
[0039] Table 1:
[0040]
[0041] Preparation: Weigh the raw material powders according to the dosage and mix them to obtain 1 preparation unit of the enteral nutrition composition, which can be packed in bags, and 1 pack or 1 bag is 1 preparation unit. Just before use, add purified water to dissolve to make a 200ml suspension, as an enteral nutrient. The prepared suspension can be heated or boiled as required, and the solution is stable without flocculation or precipitation. During preparation, for example, 1,000 preparation units can be fed, mixed thoroughly and subpackaged into 1,000 preparation units.

Example Embodiment

[0042] Example 2: Enteral nutritional composition
[0043] The composition of the product is shown in Table 2.
[0044] Table 2:
[0045]
[0046] Preparation: Weigh each raw material powder according to the dosage (wherein the magnesium chloride is magnesium chloride hexahydrate), and mix them to obtain 1 preparation unit of the enteral nutrition composition. Just before use, add purified water to dissolve to make a 200ml suspension, as an enteral nutrient. The prepared suspension can be heated or boiled as required, and the solution is stable without flocculation or precipitation.

Example Embodiment

[0047] Example 3: Enteral nutrition suspension
[0048] According to the composition in Table 1 of Example 1, take the required amount of each raw material, add purified water, dissolve and prepare a suspension of 200 ml, and make an enteral nutrition suspension after high-temperature autoclaving.
[0049] making process:
[0050] Weigh the specified amount of calcium caseinate and maltodextrin, add purified water to prepare a solution, add the specified amount of vitamin fine powder, stir for 1 hour, then add dipotassium hydrogen phosphate, magnesium chloride, and sodium chloride in turn, stir, and dissolve Afterwards, it becomes a uniformly dispersed milky white liquid, which is filtered through a sieve of 300-400 mesh, and then sterilized by autoclaving at 110 degrees.
[0051] Perform product osmolarity, pH and energy density checks. The result is: the osmotic pressure of the product is 300mOsmol/L (the osmotic pressure is measured with reference to the detection method in the second appendix of the 2015 edition of the Pharmacopoeia), which is a hypotonic solution; the measured pH value is 6.70; the energy density of the product is 80kCal/100ml (Energy density refers to the detection method of GB/Z 21922.).
[0052] Repeat the above prescription process, and change the sterilization conditions to 115 degrees autoclave sterilization, 121 degrees autoclave sterilization, each prepared three batches of samples were kept at room temperature for observation, and the temperature was 30 ° C, humidity RH60% ± 5% The accelerated test was carried out under the same conditions, and the results showed that all the indicators of the product were stable without flocculation or precipitation. Good stability.

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