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Enteral nutrition composition as well as preparation method and application thereof

A technology of enteral nutrition and composition, which is applied in the field of pharmaceutical preparations, and can solve problems such as the amount of vitamins and/or minerals not meeting the specified requirements, difficulties in transportation and storage, precipitation, etc.

Pending Publication Date: 2021-10-08
范师振
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Enteral nutrition preparations in the prior art, including enteral nutrition suspension or liquid formula, usually have the following technical problems: (1) the product is difficult to withstand high temperature sterilization, so it is difficult to reach the standard of complete sterility; (2) In order to maintain the stability of main components such as protein and fat in the preparation, the amount of vitamins and / or minerals added to the preparation often does not meet the specified requirements; (3) the product is prone to protein flocculation and precipitation, which affects its clinical application and safety; (4) as a liquid product, there are difficulties in transportation and storage

Method used

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  • Enteral nutrition composition as well as preparation method and application thereof
  • Enteral nutrition composition as well as preparation method and application thereof
  • Enteral nutrition composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1: Enteral nutritional composition

[0038] The product composition is shown in Table 1.

[0039] Table 1:

[0040]

[0041] Preparation: Weigh the raw material powders according to the dosage and mix them to obtain 1 preparation unit of the enteral nutrition composition, which can be packed in bags, and 1 pack or 1 bag is 1 preparation unit. Just before use, add purified water to dissolve to make a 200ml suspension, as an enteral nutrient. The prepared suspension can be heated or boiled as required, and the solution is stable without flocculation or precipitation. During preparation, for example, 1,000 preparation units can be fed, mixed thoroughly and subpackaged into 1,000 preparation units.

Embodiment 2

[0042] Example 2: Enteral nutritional composition

[0043] The composition of the product is shown in Table 2.

[0044] Table 2:

[0045]

[0046] Preparation: Weigh each raw material powder according to the dosage (wherein the magnesium chloride is magnesium chloride hexahydrate), and mix them to obtain 1 preparation unit of the enteral nutrition composition. Just before use, add purified water to dissolve to make a 200ml suspension, as an enteral nutrient. The prepared suspension can be heated or boiled as required, and the solution is stable without flocculation or precipitation.

Embodiment 3

[0047] Example 3: Enteral nutrition suspension

[0048] According to the composition in Table 1 of Example 1, take the required amount of each raw material, add purified water, dissolve and prepare a suspension of 200 ml, and make an enteral nutrition suspension after high-temperature autoclaving.

[0049] making process:

[0050] Weigh the specified amount of calcium caseinate and maltodextrin, add purified water to prepare a solution, add the specified amount of vitamin fine powder, stir for 1 hour, then add dipotassium hydrogen phosphate, magnesium chloride, and sodium chloride in turn, stir, and dissolve Afterwards, it becomes a uniformly dispersed milky white liquid, which is filtered through a sieve of 300-400 mesh, and then sterilized by autoclaving at 110 degrees.

[0051] Perform product osmolarity, pH and energy density checks. The result is: the osmotic pressure of the product is 300mOsmol / L (the osmotic pressure is measured with reference to the detection method ...

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Abstract

The invention provides an enteral nutrition composition. According to the composition, maltodextrin is taken as carbohydrate, calcium caseinate is taken as protein and dipotassium phosphate is taken as a potassium source, so that a prepared enteral nutrition preparation product, such as an enteral nutrition suspension, has good energy density and osmotic pressure, is resistant to high-temperature hot-pressing treatment, is free of flocculation, precipitation and other phenomena, is good in stability, is easy to form a suspension after being added with water, can tolerate heat treatment such as boiling, meets the requirement that an enteral nutrition agent is prepared immediately when being used, reduces the product transportation and storage cost, and achieves an unexpected technical effect.

Description

technical field [0001] The invention provides an enteral nutrition composition, its preparation method and application. The enteral nutrition composition is used for enteral nutrition preparations, such as enteral nutrition suspension and the like. It belongs to the field of pharmaceutical preparations. Background technique [0002] Enteral nutrition preparations combined with drugs or surgical treatment can positively promote the outcome of the disease and the improvement of the nutritional status of patients. Enteral nutrition suspension is a common enteral nutrition preparation in formula food for special medical purposes. Patients with gastrointestinal function or partial gastrointestinal function who are unable or unwilling to eat a sufficient amount of conventional food to meet the nutritional needs of the body should be treated with enteral nutrition. CN111194912A discloses a stable medical liquid enteral nutrition composition and its preparation method as an enter...

Claims

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Application Information

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IPC IPC(8): A23L33/125A23L33/15A23L33/155A23L33/16A23L33/19
CPCA23L33/125A23L33/15A23L33/155A23L33/16A23L33/19A23V2002/00A23V2200/30A23V2250/5114A23V2250/54246A23V2250/70A23V2250/156
Inventor 范师振
Owner 范师振
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