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Novel hypertension model and establishment and application thereof

A high blood pressure and model technology, applied in veterinary instruments, veterinary surgery, medical science, etc., can solve problems such as lack of high blood pressure, and achieve the effect of high success rate and obvious rising trend of blood pressure

Pending Publication Date: 2021-10-15
吕有魁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For this reason, the present invention provides a new type of hypertension model and its establishment and application to solve the lack of a model of hypertension caused by atlantoaxial joint disorders in the prior art, so as to facilitate the subsequent diagnosis and treatment of hypertension caused by atlantoaxial joint disorders. Lay the groundwork for further research

Method used

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  • Novel hypertension model and establishment and application thereof
  • Novel hypertension model and establishment and application thereof
  • Novel hypertension model and establishment and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 A kind of novel hypertension model

[0032] A new type of hypertension model consisting of rats and implants;

[0033] The insert is an aluminum metal insert made of 24 / 6 staples, connected by a 1mm head to a 3mm neck, and the neck is connected to a 3mm metal body. The insert is 0.5mm wide and 0.25cm thick. see details figure 1 shown. The implant is placed at the atlantoaxial joint.

Embodiment 2

[0034] Embodiment 2 A kind of establishment method of novel hypertension model

[0035] After the rats were weighed, they were anesthetized by intraperitoneal injection of 3% sodium phenobarbital (3 mg / 100 g). After anesthesia, the mouse board was fixed, and then the hair on the neck of the rat was shaved with a razor, and disinfected with povidone iodine. Use a scalpel along the front of the neck to make a longitudinal incision along the neck, separate the subcutaneous tissue layer by layer, and bluntly dissect the muscle layer by layer until the left atlantoaxial joint of the rat is fully exposed, see figure 2 As shown, rotate the head to the right to expose the left atlantoaxial joint. Choose special aluminum metal built-in. After disinfection, use the needle holder in your right hand to hold the implant and insert it into the left atlantoaxial space, see image 3 shown, after confirming that the built-in is in place (see Figure 4 shown), the wound was sutured, and pe...

experiment example

[0039] The blood pressure change trend graph of the model rats prepared in Example 2 and the control example is shown in Figure 5 shown. Depend on Figure 5 It can be seen that the insertion of metal foreign objects outside the atlantoaxial joint in rats can lead to disorder of the atlantoaxial joint and increase blood pressure in rats. Therefore, the present invention can be used in the research of simulating human hypertension caused by atlantoaxial joint disorder.

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Abstract

The invention discloses a novel hypertension model and establishment and application thereof. According to the novel hypertension model, a rat is selected as an experimental animal, atlantoaxial joint disorder is mechanical equilibrium stability damage, and compared with a model obtained through other methods (drug Freund's complete adjuvant and manual resistance rotation), the success rate is high, and the blood pressure rising trend is most obvious. According to the invention, the atlantoaxial lateral joint internal metal built-in object (which is beneficial to radiography development and fixation) is adopted, and after the built-in object in the atlantoaxial joint is further taken out, the atlantoaxial lateral joint internal metal built-in object simulates manual reduction, so that the blood pressure drop can be observed. The invention can be used for further research on hypertension caused by atlantoaxial joint disorder in the later period.

Description

technical field [0001] The invention relates to the field of animal experiment equipment, in particular to a novel hypertension model and its establishment and application. Background technique [0002] Hypertension is a common and frequently-occurring disease that seriously affects human health. However, commonly used rat hypertension models include spontaneously hypertensive rat models, transgenic hypertensive rat models, environmental hypertensive animal models, drug-induced hypertensive animal models, renovascular hypertensive animal models, neurogenic hypertensive rat models, Hypertension animal models, etc. However, the method of the atlantoaxial joint disorder model has not been reported. [0003] In clinical work, the experimenters found that some patients with cervical spondylosis accompanied by hypertension or hypotension, after treatment of the cervical spine, found that the blood pressure of the patients also improved; while some hypertensive patients with cerv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D1/00A01K67/02
CPCA61D1/00A01K67/02A01K2227/105A01K2267/0375
Inventor 何宗宝吕有魁杨彬高顶平李辉姚琼陈阳陶秀传
Owner 吕有魁
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