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Chromatographic valve linked mobile electrospray ion source accurate positioning device

An electrospray ion source and precise positioning technology, applied in the field of mass spectrometry, can solve problems such as restricting the performance and use of liquid-mass spectrometry, inconvenient operation and maintenance, improve automation level and use efficiency, expand performance and application scope, The effect of precise positioning

Pending Publication Date: 2021-10-19
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Even, for some direct injection capillary columns, the column can only be installed manually by shutting down the machine
This not only makes operation and maintenance more inconvenient, but also restricts the instrument performance and application of liquid-mass spectrometry

Method used

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  • Chromatographic valve linked mobile electrospray ion source accurate positioning device
  • Chromatographic valve linked mobile electrospray ion source accurate positioning device
  • Chromatographic valve linked mobile electrospray ion source accurate positioning device

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Embodiment Construction

[0042]In order to make the objects, technical solutions, and advantages of the present invention more clear, the technical solutions of the embodiments of the present invention will be described in contemplation in conjunction with the drawings of the embodiments of the present invention. Obviously, the described embodiments are embodiments of the invention, not all of the embodiments. Based on the embodiments described herein, all other embodiments obtained without the need for creative labor without the need for creative labor.

[0043] Unless otherwise defined, the technical terms or scientific terms used in the present invention should be understood by those who have general skills in the art of the present invention. "First", "second" and similar words used in the present invention do not represent any order, quantity, or importance, but is only used to distinguish different components. Similar words to "include" or "include", or the like, the element or article that appears ...

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Abstract

The embodiment of the invention provides a chromatographic valve linked mobile electrospray ion source accurate positioning device, which is used for connection of a liquid chromatograph and a mass spectrometer. The liquid chromatograph is connected with a chromatographic valve, a valve head of the chromatographic valve is provided with a plurality of interfaces communicated with the chromatographic valve, and the accurate positioning device comprises a connection support arranged on a mass spectrum panel, a loading tray arranged on the connection support, a controller, a sensor connected with the controller and used for sensing rotation position information of the valve head and sending the rotation position information to the controller, and a driving mechanism connected with the controller. The controller determines the capillary chromatographic column connected to the liquid chromatograph according to the received rotation position information and enables the capillary chromatographic column to be opposite to the mass spectrum ion injection port. By utilizing the linkage of the inductor and the chromatographic valve, the accurate positioning of the capillary chromatographic column can be realized, the full-automatic online switching and selection of the capillary chromatographic column can be realized, the performance and the application range of the instrument are expanded, and the automation level and the use efficiency of the instrument are improved.

Description

Technical field [0001] The present invention belongs to the field of mass spectrometry, and in particular to a precision positioning device for ion source devices, and more particularly to a chromatographic cossivation of mobile electrospray ion source precision positioning devices. Background technique [0002] The mass spectrometry ion source is an apparatus for ionization of neutral atoms or molecules and from the ion beam flow. Electrospray Ionization, ESI ion source is the most commonly used connection equipment for liquid chromatography and mass spectrometry, which can be used to study compounds of thermally unstable and large polarity, especially in the field of protein analysis. [0003] At present, the existing electrospray ion source is typically provided by a fixed bracket in front of a mass spectrometry ion implant opening, and a high voltage is applied to the electrospray injection needle or the substance to be tested. The fixing bracket can only manually fine-tuning...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88
CPCG01N30/88
Inventor 周虎高婧何晗朱洪文赵达明常玉洁黄锐敏范晓明
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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