Therapeutic nanoconjugates and uses thereof

A nanoparticle and fusion protein technology, which is applied in the field of nanostructured protein materials, can solve the problems of complex and cumbersome antibody structures and obstacles
CN113597318APending Publication Date: 2021-11-02巴塞罗那自治大学UAB +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
巴塞罗那自治大学UAB
Publication Date
2021-11-02

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Abstract

The present invention relates to nanostructured conjugates, more specifically to nanostructured fusion proteins suitable for the selective delivery of their conjugated therapeutic agents to specific cell and tissue types. It also relates to nanoparticles comprising such nanostructured proteins and the therapeutic uses thereof.
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Description

technical field

[0001] The present invention relates to the field of nanostructured protein materials, and more particularly relates to fusion proteins carrying therapeutic agents that can be used for treatment. Background technique

[0002] Systemic administration of drugs in the form of nanoconjugates benefits from enhanced drug stability when compared to free molecules. Valuable additional properties such as cell targeting can also be incorporated into a given hybrid composite by chemically incorporating functional groups in the nanoscale carrier, thereby benefiting from the high surface area / volume ratio of nanomaterials . When administered systemically, the resulting drug-loaded conjugates with sizes between about 8 and 100 nm escape renal filtration without aggregation in the lung or other highly vascularized organs. This fact, combined with appropriate physicochemical properties of the material, may lead to prolonged circulation times and drug exposure to target org...

Claims

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