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Sustained release tablet containing sodium valproate and preparation method thereof

A technology of sodium valproate and sustained-release tablets, which is applied in the field of medicine, and can solve problems such as unstable release, short release time, and complicated prescription ingredients of sodium valproate sustained-release tablets

Pending Publication Date: 2021-11-09
南京泽恒医药技术开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The problem to be solved by the present invention is that the sodium valproate sustained-release tablets in the prior art have complex ingredients, high price, high requirements for production process technology control, unstable release, short release time, and possible technical problems such as sudden release.

Method used

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  • Sustained release tablet containing sodium valproate and preparation method thereof
  • Sustained release tablet containing sodium valproate and preparation method thereof
  • Sustained release tablet containing sodium valproate and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Prescription for Sodium Valproate Extended Release Tablets:

[0031]

[0032]

[0033] Preparation process: Add ethyl cellulose to valproic acid and mix to make a uniform solution. Add sodium valproate, hypromellose and lactose that have been sieved in advance into the wet granulator, stir and mix evenly, add valproic acid solution to granulate, add silicon dioxide and magnesium stearate, and mix evenly , Tablets. Add hypromellose into purified water, disperse evenly, add acrylic resin, mix evenly, and make coating liquid. The plain tablet is put into a coating pan, sprayed into the above-mentioned coating solution for coating, and the coating temperature is controlled at 30-50°C.

Embodiment 2

[0035] Prescription for Sodium Valproate Extended Release Tablets:

[0036]

[0037] Preparation process: Add ethyl cellulose to valproic acid and mix to make a uniform solution. Sodium valproate that has passed through a 40-mesh sieve in advance is added to the wet granulator together with hypromellose and mannitol, stirred and mixed evenly, added valproic acid solution to granulate, added silicon dioxide and magnesium stearate, and mixed Uniform, tablet. Add hydroxypropyl cellulose into purified water, disperse evenly, add acrylic resin, mix evenly, and make coating solution. The plain tablet is put into a coating pan, sprayed into the above-mentioned coating solution for coating, and the coating temperature is controlled at 30-50°C.

Embodiment 3

[0039] Prescription for Sodium Valproate Extended Release Tablets:

[0040]

[0041]

[0042] Preparation process: Add ethyl cellulose to valproic acid and mix to make a uniform solution. Add sodium valproate, hypromellose and lactose that have been sieved in advance into the wet granulator, stir and mix evenly, add valproic acid solution to granulate, add silicon dioxide and magnesium stearate, and mix evenly , Tablets.

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Abstract

The invention aims to provide a sodium valproate sustained release tablet which is stable in drug release and safer in medication. The sodium valproate sustained release tablet is characterized by consisting of sodium valproate, valproic acid and physiologically acceptable auxiliary materials. The sustained release tablet provided by the invention has the characteristics of cheap and easily available prescription composition, simple process equipment, constant and lasting drug release and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and belongs to the technology of sustained and controlled release preparations, in particular to a sustained release tablet containing sodium valproate and a preparation method thereof. Background technique [0002] Sustained-release preparations refer to preparations that can slowly release drugs in a prescribed release medium. The drug release of the active ingredient in the sustained-release preparation is relatively slow, and the blood concentration can be maintained for a long time after the drug is absorbed into the blood. The sustained-release preparation can reduce the "peak and valley" phenomenon due to the blood concentration of the drug, thereby reducing toxic and side effects. For patients who take medicine, the sustained-release preparation can reduce the number of times of taking medicine and improve the patient's compliance. [0003] Epilepsy is a chronic disease in which the sud...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/38A61K47/32A61K31/19A61P25/08
CPCA61K9/2054A61K9/2027A61K9/2095A61K31/19A61P25/08
Inventor 胡雄林熊冬冬赵亚男赵雪琴韩淑娴
Owner 南京泽恒医药技术开发有限公司
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