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Application of ferroptosis inhibitor Liproxstatin-1 in preparation of drugs for relieving renal fibrosis

A technology for renal fibrosis and ferroptosis, applied in the field of biomedicine, can solve the problems of unclear effects and mechanisms of ferroptosis, and achieve the effect of inhibiting activation

Inactive Publication Date: 2021-11-09
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, Liproxstatin-1 is an effective inhibitor of ferroptosis, but so far, the role and mechanism of ferroptosis in renal fibrosis is still unclear, and there is no report on the treatment of renal fibrosis with Liproxstatin-1

Method used

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  • Application of ferroptosis inhibitor Liproxstatin-1 in preparation of drugs for relieving renal fibrosis
  • Application of ferroptosis inhibitor Liproxstatin-1 in preparation of drugs for relieving renal fibrosis
  • Application of ferroptosis inhibitor Liproxstatin-1 in preparation of drugs for relieving renal fibrosis

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] animal handling

[0039] 8-week-old male C57BL / 6 mice. All experimental animal procedures were approved by the Ethics Committee of the Scientific Research Center of Central South University (Changsha, China). Mice were anesthetized with sodium pentobarbital (80 mg / kg; ip) and every effort was made to minimize animal suffering during and after surgery.

[0040] animal model

[0041]A unilateral ureteral obstruction (UUO) model was constructed. Cut off the skin, fascia and muscles in the middle and lower part of the back of the mouse to reveal the left kidney. Use a glass minute needle to gently separate along the lower level of the kidney to expose the left ureter. Ligate it with two 4-0 silk threads. Ureters were disconnected to prevent retrograde urinary tract infection. The wound was fully washed with gentamicin and sucked out. The internal muscles and fascia were sutured continuously with 4-0 silk suture, and the skin was sutured intermittently with 3-0 silk sutu...

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Abstract

The invention discloses application of a ferroptosis inhibitor Liproxstatin-1 in preparation of drugs for relieving renal fibrosis, and belongs to the technical field of biological medicines. The system of the invention clarifies the occurrence of iron deposition and the expression of ferroptosis-related proteins in a renal fiber model caused by unilateral ureteral ligation of mice; and meanwhile, the ferroptosis inhibitor Liproxstatin-1 is administered intraperitoneally, which proves that the Liproxstatin-1 can inhibit ferroptosis of renal tubular epithelial cells, thereby inhibiting the secretion of fibrosis-promoting factors TGF-beta1, CTGF and PDGF and the activation of myofibroblasts, finally reducing the degree of renal fibrosis of mice, and providing potential drugs and new ideas for the treatment of renal fibrosis.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of a ferroptosis inhibitor Liproxstatin-1 in the preparation of drugs for alleviating renal fibrosis. Background technique [0002] Renal fibrosis is a common path and main pathological process in the progression of various chronic kidney diseases (CKD) to the end stage, which is characterized by the destruction of normal kidney structures, fibroblast proliferation, and excessive deposition of extracellular matrix. Renal fibrosis can be caused by a complex set of etiologies, such as obstructive, inflammatory, immune, metabolic or other systemic diseases. There is currently no effective way to slow the progressive impairment of renal function in chronic kidney disease or to completely delay the progression of renal fibrosis, and treatment options for patients with end-stage renal disease are limited to dialysis and kidney transplantation. Although a series of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/499A61P13/12
CPCA61K31/499A61P13/12
Inventor 张波周艳陈湘何垚陈志李冰晟甘宇
Owner CENT SOUTH UNIV
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