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Application of oral fullerene material in preparation of medicine for treating gastric ulcer

A technology of fullerenes and fullerene lipids, applied in the field of biomedicine, can solve problems such as easy recurrence, large side effects, and drug resistance

Pending Publication Date: 2021-11-16
INST OF CHEM CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many drugs for the treatment of gastric ulcer disease, mainly including proton pump inhibitors, H2 receptor antagonists, gastric mucosal protective agents, etc. Side effects, recurrence, etc.

Method used

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  • Application of oral fullerene material in preparation of medicine for treating gastric ulcer
  • Application of oral fullerene material in preparation of medicine for treating gastric ulcer
  • Application of oral fullerene material in preparation of medicine for treating gastric ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Embodiment 1: Preparation of oral fullerene material (fullerene oil agent and water-soluble fullerene composition)

[0073] S1: fullerene-olive oil (C 60 -Oil) preparation

[0074] Measure 50ml olive oil, weigh 50mg C 60, mix and stir evenly, and then put the mixed solution in a ball mill for ball milling for 10 hours. After the ball milling, take out the mixed solution, store it in a cool, dry and dark place, centrifuge after standing for a certain period of time, and filter to obtain a fullerene-olive oil solution (C 60 -Oil), the preparation process is as figure 1 shown.

[0075] S2: Water-soluble metal fullerene Gd@C 82 - Preparation of Ala composition

[0076] 50mg metal fullerene Gd@C 82 The solid powder was dissolved in toluene and ultrasonically dissolved, then 3.6g of β-alanine was added to the solution, 14% NaOH was slowly added dropwise to the solution, reacted at 80°C for 5h, and then the solution was dialyzed in a dialysis bag to obtain Water-solubl...

Embodiment 2

[0077] Embodiment 2: the content determination of oral fullerene material

[0078] (1)C 60 -Oil concentration was determined by UV-Vis absorption spectroscopy.

[0079] Prepare a fixed concentration of C 60 Toluene solution, 5, 10, 15, 20, 25ppm, measure its ultraviolet absorption spectrum, such as image 3 Shown, C 60 There is a characteristic absorption at 334nm, take the values ​​of concentration and absorbance, and perform linear fitting to obtain a linear curve. Measure the prepared C 60 -UV-visible absorption curve of Oil, and then calibrate its concentration, which is 870ppm.

[0080] (2)Gd@C 82 -Ala was tested for its concentration by inductively coupled plasma mass spectrometry (ICP-MS).

[0081] 100μLGd@C 82 -Ala, add 1mL nitric acid for digestion, release Gd ions, and then perform ICP-MS test to measure Gd ion concentration, which is Gd@C 82 - the molar concentration of Ala, set the concentration to 1 mM for subsequent experiments.

Embodiment 3

[0082] Example 3: Effect of oral fullerene materials in preventing ethanol-induced gastric ulcer disease in animal experiments

[0083] Experimental animals and groups:

[0084] ICR mice, male, 20-25g, 6 in each group;

[0085] Experimental group 1: Ethanol modeling + oral administration of fullerene oil C 60 -Oil;

[0086] Experimental group 2: Ethanol modeling + oral administration of water-soluble fullerene Gd@C 82 - Ala composition;

[0087] Model group: ethanol modeling + oral saline;

[0088] Blank control group: oral normal saline + oral normal saline;

[0089] experiment process:

[0090] The mice in each group were fasted for 24 hours, and then the experimental group 1 and the experimental group 2 were given oral administration of fullerene oil C 60 -Oil and water-soluble fullerene Gd@C 82 - Each 10mL / kg of Ala composition, oral normal saline in model group; After 30 minutes, except blank control group, each experimental group and model group oral dehydrated a...

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Abstract

The invention provides application of an oral fullerene material in preparation of a medicine for treating and / or preventing gastric ulcer and application of the oral fullerene material in preparation of a gastric mucosa protective agent.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of an oral fullerene material in the preparation of medicines for treating and / or preventing gastric ulcer. Background technique [0002] Gastric ulcer disease (Gastric ulcer, GU) is a global multiple digestive tract disease and one of the most common gastrointestinal diseases, with an incidence rate of 10%, and about four million new cases each year. Seriously endanger people's quality of life and life and health. Gastric ulcer refers to peptic ulcer that occurs between the cardia and pylorus, and is a gastric mucosal lesion mainly characterized by inflammatory erosion, superficial ulcer and bleeding. The pathogenesis of gastric ulcer is mainly due to the imbalance between the enhancement of local gastric acid, pepsin, and Helicobacter pylori in the gastric mucosa and the weakening of mucus-carbonic acid-barrier and mucosal repair protection mechanisms, which are rela...

Claims

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Application Information

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IPC IPC(8): A61K33/44A61P1/04A61P7/04A61P29/00A23L33/00
CPCA61K33/44A61K9/0053A61P1/04A61P7/04A61P29/00A23L33/00A23V2002/00A23V2200/32
Inventor 王春儒李雪刘雷
Owner INST OF CHEM CHINESE ACAD OF SCI
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