Pharmaceutical composition for eliminating phlegm and removing dampness and application thereof

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of limited therapeutic effect of patients with coronary heart disease, achieve the effect of reducing inflammatory cell infiltration, good therapeutic effect, and inhibition of myocardial hypertrophy

Active Publication Date: 2021-11-16
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Traditional Chinese medicine believes that coronary heart disease is caused by blood stasis, phlegm and dampness blocking the heart, so there is a classic prescription "Gualou Xiebai Banxia Decoction" (see "Synopsis of the Golden Chamber" by Zhang Zhongjing for details. Gualou Xiebai Banxia Decoction should be used"), however, the treatment effect of this prescription on a considerable number of patients with coronary heart disease such as coronary heart disease with phlegm-dampness syndrome is very limited, so it needs to be improved according to local conditions and people's conditions, so that it can benefit more coronary heart disease patients

Method used

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  • Pharmaceutical composition for eliminating phlegm and removing dampness and application thereof
  • Pharmaceutical composition for eliminating phlegm and removing dampness and application thereof
  • Pharmaceutical composition for eliminating phlegm and removing dampness and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Phlegm dehumidification soup was prepared from the following components: Trichosanthes 30g, scallion white 30g, France Pinellia 15g, Codonopsis 20g, Curcuma 15g, Coptis 6g.

[0050] Take the above components, prepared according to the method of the prior decoction soup prepared Huotan dehumidification, the ratio of the amount of a drug, a drug of about 200mL.

[0051] Illustratively, it may take the following Huotan dehumidifying soup prepared by conventional methods:

[0052] A fried: Recipe full scale 1g crude drug 8mL of water was added water to soak for about 30min, boiled for about 30min, hot filtered through four layers of gauze, and the filtrate obtained NATURAL dropwise a first filtrate and a first rear residues do;

[0053] Second dose: 1g crude drug proportion of water was added 6mL of water was added to the first residue boiled about 30min and filtered, the filtrate was retained second, two filtrates were combined, that is, too.

[0054] It should be noted that o...

Embodiment 2

[0056] Phlegm desiccant particles, was prepared from the following components: Trichosanthes 30g, scallion white 30g, France Pinellia 15g, Codonopsis 20g, Curcuma 15g, Coptis 6g.

[0057] Take the above components, added to the carrier and / or excipient, prepared according to the method of the prior Chinese medicine granules prepared Huotan desiccant particles 1000g.

[0058] Illustratively, the particles may take the following Huotan dehumidifying prepared by conventional methods:

[0059] Example 1 was prepared according to the procedures of the embodiment decoction filtrate, and the filtrate was concentrated under reduced pressure to give clear paste to the paste Jiamai maltodextrin clear, then spray dried to obtain dry cream powder; then again shoots dry extract powder Jiamai dextrin to obtain a mixed powder; was then added to the mixed powder volume fraction of 90% ethanol - aqueous solution of the soft material, the soft material is sieved to obtain wet granules. Finally, t...

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Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a phlegm-eliminating and dampness-eliminating pharmaceutical composition and application thereof. The phlegm-eliminating and dampness-eliminating pharmaceutical composition is prepared from the following raw material components in parts by mass: 15-30 parts of fructus trichosanthis, 9-30 parts of allium macrostemon, 9-15 parts of rhizoma pinellinae praeparata, 9-30 parts of codonopsis pilosula, 6-15 parts of curcuma zedoary and 2-6 parts of coptis chinensis. A coronary heart disease damp syndrome mouse model experiment shows that the phlegm eliminating and dampness eliminating formula can remarkably improve ST segment and T wave pressure of a coronary heart disease damp syndrome mouse, inhibit myocardial hypertrophy of the coronary heart disease damp syndrome mouse, reduce leakage of myocardial injury zymogram of CK-MB, cTnT, LDH and oxLDL, protect myocardial tissue of ischemia injury, reduce cardiac enlargement caused by isoprenaline, reduce cardiomyopathy change caused by isoprenaline treatment, keep more myocardial cell structures normal, reduce inflammatory cell infiltration, stabilize membrane structures and reduce edema degree, thereby having a better treatment effect on ischemic heart disease or angina pectoris.

Description

Technical field [0001] The present invention belongs to the field of medicine, particularly, to a dehumidifier Huotan pharmaceutical composition and uses. Background technique [0002] Coronary heart disease is coronary angiogenesis atherosclerosis lesions caused by vascular stenosis or occlusion, resulting in myocardial ischemia, hypoxia or necrosis caused by heart disease, often called "coronary heart disease." World Health Organization coronary heart disease will be divided into five categories: silent myocardial ischemia (occult coronary artery disease), angina, myocardial infarction, ischemic heart failure (ischemic heart disease) and five clinical types sudden death. [0003] For the treatment of coronary heart disease due to percutaneous coronary intervention (percutaneous coronaryintervention, PCI) and coronary artery bypass graft surgery (coronary artery bypass graft, CABG) continuous development and improvement, the treatment success rate has increased, but still a sign...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P9/10
CPCA61K36/428A61K36/8962A61K36/8888A61K36/344A61K36/9066A61K36/718A61P9/10A61K2300/00
Inventor 吕渭辉陈可冀江巍
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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